A series of novel indole derivatives were designed and synthesized and their inhibitory activity against B-Raf and HepG2 cell were also described. Among them, compounds 7a and 7b exhibited excellent potency, which sho...A series of novel indole derivatives were designed and synthesized and their inhibitory activity against B-Raf and HepG2 cell were also described. Among them, compounds 7a and 7b exhibited excellent potency, which showed the potential for further research as lead compounds.展开更多
基金financially supported by the Natural Science Foundation of Jiangsu Province(No.BK2009303)the National Natural Science Foundation of China(No.30973609)+1 种基金Fundamental Research Funds for the Central Universities(No.JKZ2011004)Specialized Research Fund for the Doctoral Program of Higher Education(No.20100096110007)
文摘A series of novel indole derivatives were designed and synthesized and their inhibitory activity against B-Raf and HepG2 cell were also described. Among them, compounds 7a and 7b exhibited excellent potency, which showed the potential for further research as lead compounds.
