This paper introduces relative and absolute gravity change observations in the eastern portion of the Tibetan Plateau. We analyze and discuss a change that occurred in 2010 in the gravity along the eastern margin of t...This paper introduces relative and absolute gravity change observations in the eastern portion of the Tibetan Plateau. We analyze and discuss a change that occurred in 2010 in the gravity along the eastern margin of the plateau and the relationship between this change and the 2013 Lushan Ms7.0 earthquake. Our results show that: (1) before the Lushan MsT.0 earthquake, gravity anomalies along the eastern margin of the Tibetan Plateau changed drastically. The Lushan earthquake occurred at the bend of the high gradient zone of gravity var- iation along the southern edge of the Longmenshan fault zone. (2) The 2013 Lushan earthquake occurred less than 100 km away from the epicenter of the 2008 Wenchuan earthquake. Lushan and Wenchuan are located at the center of a four- quadrant section with different gravity anomalies, which may suggest that restoration after the Wenchuan earthquake may have played a role in causing the Lushan earthquake. (3) A medium-term prediction based on changes in gravity anoma- lies was made before the Lushan Ms7.0 earthquake, in par- ticular, a prediction of epicenter location.展开更多
Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of A...Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients.展开更多
基金supported by the National Natural Science Foundation of China(41274083)Special Earthquake Research Project Grant by China Earthquake Administration(201208009)
文摘This paper introduces relative and absolute gravity change observations in the eastern portion of the Tibetan Plateau. We analyze and discuss a change that occurred in 2010 in the gravity along the eastern margin of the plateau and the relationship between this change and the 2013 Lushan Ms7.0 earthquake. Our results show that: (1) before the Lushan MsT.0 earthquake, gravity anomalies along the eastern margin of the Tibetan Plateau changed drastically. The Lushan earthquake occurred at the bend of the high gradient zone of gravity var- iation along the southern edge of the Longmenshan fault zone. (2) The 2013 Lushan earthquake occurred less than 100 km away from the epicenter of the 2008 Wenchuan earthquake. Lushan and Wenchuan are located at the center of a four- quadrant section with different gravity anomalies, which may suggest that restoration after the Wenchuan earthquake may have played a role in causing the Lushan earthquake. (3) A medium-term prediction based on changes in gravity anoma- lies was made before the Lushan Ms7.0 earthquake, in par- ticular, a prediction of epicenter location.
基金supported by National Science and Technology Major Project (2013ZX10002005 and 2017ZX10203202).
文摘Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients.