BACKGROUND Recently,many investigations have suggested that the rs3746444 T>C locus in the microRNA(miR)-499 gene may contribute to the occurrence of cancer.However,reports on the association between rs3746444 and ...BACKGROUND Recently,many investigations have suggested that the rs3746444 T>C locus in the microRNA(miR)-499 gene may contribute to the occurrence of cancer.However,reports on the association between rs3746444 and hepatocellular carcinoma(HCC)are conflicting.AIM To further understand and explore the potential correlation between the singlenucleotide polymorphism of rs3746444 and the incidence of HCC.METHODS In this meta-analysis,we obtained electronic literature by searching the PubMed,Embase and Chinese BioMedical Disc databases(through May 20,2022).All eligible case-control,prospective cohort or nested case-control studies with sufficient data for calculating the odds ratios with their 95%confidence intervals were included.RESULTS Ultimately,a total of 17 independent studies were included.We identified that rs3746444 was associated with the development of HCC(C vs T:P=0.019 and CC/CT vs TT:P=0.016).In Asian individuals,rs3746444 was associated with susceptibility to HCC(C vs T:P=0.013 and CC/CT vs TT:P=0.016).In addition,this study identified that the miR-499 rs3746444 locus was associated with susceptibility to HCC in the normal/healthy control subgroup(C vs T:P=0.034 and CC/CT vs TT:P=0.024).CONCLUSION In summary,this meta-analysis highlights that rs3746444 in the miR-499 gene is involved in the occurrence of HCC,especially in Asian individuals.展开更多
基金Supported by Fujian Provincial Clinical Research Center for Cancer Radiotherapy and Immunotherapy,No.2020Y2012the Startup Fund for Scientific Research,Fujian Medical University,No.2019QH1071+2 种基金the Science and Technology Supporting Project of Changzhou City,No.CE20205034Joint Funds for the Innovation of Science and Technology,Fujian Province,No.2021Y9227the National Natural Science Foundation of China,No.U1705282.
文摘BACKGROUND Recently,many investigations have suggested that the rs3746444 T>C locus in the microRNA(miR)-499 gene may contribute to the occurrence of cancer.However,reports on the association between rs3746444 and hepatocellular carcinoma(HCC)are conflicting.AIM To further understand and explore the potential correlation between the singlenucleotide polymorphism of rs3746444 and the incidence of HCC.METHODS In this meta-analysis,we obtained electronic literature by searching the PubMed,Embase and Chinese BioMedical Disc databases(through May 20,2022).All eligible case-control,prospective cohort or nested case-control studies with sufficient data for calculating the odds ratios with their 95%confidence intervals were included.RESULTS Ultimately,a total of 17 independent studies were included.We identified that rs3746444 was associated with the development of HCC(C vs T:P=0.019 and CC/CT vs TT:P=0.016).In Asian individuals,rs3746444 was associated with susceptibility to HCC(C vs T:P=0.013 and CC/CT vs TT:P=0.016).In addition,this study identified that the miR-499 rs3746444 locus was associated with susceptibility to HCC in the normal/healthy control subgroup(C vs T:P=0.034 and CC/CT vs TT:P=0.024).CONCLUSION In summary,this meta-analysis highlights that rs3746444 in the miR-499 gene is involved in the occurrence of HCC,especially in Asian individuals.
