Change and clinical significance of serum PG in patients with chronic gastritis

Objective:To observe the change and clinical significance of serum PG in patients with chronic atrophic gastritis (CAG).Methods:ELISA was used to detect the peripheral blood PG level in patients confirmed with CAG, gastric polyps, and gastric cancer who were admitted in our hospital from January, 2015 to January, 2016. The normal individuals who came for physical examinations were served as the control group. The peripheral blood PG level in patients with various gastric diseases was observed.Results: The serum PGⅠ expression and PG I/PGⅡ in the gastritis group were significantly lower than those in the gastric polyps group and control group, but were significantly higher than those in the gastric cancer group;while PGⅡ expression was significantly higher than that in the gastric polyps group and control group, but was significantly lower than those in the gastric cancer group. PGⅠ expression and PG I/ PGⅡ in the gastric polyps group were significantly higher than those in the gastritis group and gastric cancer group, while PGⅡ expression was significantly lower than that in the gastritis group and gastric cancer group. PGⅠ expression and PG I/ PGⅡ in the gastric cancer group were significantly lower than those in the other three groups, while PGⅡ expression was significantly higher than that in the other three groups. The serum PGⅠ expression in patients with positive HP infection in the gastritis group and gastric cancer group was significantly higher than that in patients with negative HP infection, but the comparison of PG I/ PGⅡ was not statistically significant. The serum PGⅠ expression and PG I/ PGⅡ in patients with negative and positive HP infection in the gastritis group were significantly higher than those in patients with negative and positive HP infection in the gastric cancer group;while PGⅡ expression was significantly was significantly lower than that in the gastric cancer group.Conclusions: PGⅠ expression and PG I/ PGⅡ in patients with CAG are significantly reduced, but PGⅡ expression is significantly strengthened;while PGⅠ expression and PG I/ PGⅡ are significantly higher than those in the gastric cancer group, but PGⅡ expression is significantly lower than that in the gastric cancer group. It should pay attention to the changes of the above indicators in the clinical treatment. If PGⅠ expression and PG I/ PGⅡ are significantly reduced, but PGⅡ expression is significantly strengthened, it should pay attention to the probability of condition deterioration.