Treatment and functional reconstruction after central nervous system injury is a major medical and social challenge. An increasing number of researchers are attempting to use neural stem cells combined with artificial...Treatment and functional reconstruction after central nervous system injury is a major medical and social challenge. An increasing number of researchers are attempting to use neural stem cells combined with artificial scaffold materials, such as fibroin, for nerve repair. However, such approaches are challenged by ethical and practical issues. Amniotic tissue, a clinical waste product, is abundant, and amniotic epithe- lial cells are pluripotent, have low immunogenicity, and are not the subject of ethical debate. We hypothesized that amniotic epithelial cells combined with silk fibroin scaffolds would be conducive to the repair of spinal cord injury. To test this, we isolated and cultured amniotic epithelial cells, and constructed complexes of these cells and silk fibroin scaffolds. Implantation of the cell-scaffold complex into a rat model of spinal cord injury resulted in a smaller glial scar in the damaged cord tissue than in model rats that received a blank scaffold, or amniotic epithelial cells alone. In addition to a milder local immunological reaction, the rats showed less inflammatory cell infiltration at the trans- plant site, milder host-versus-graft reaction, and a marked improvement in motor function. These findings confirm that the transplantation of amniotic epithelial ceils combined with silk fibroin scaffold can promote the repair of spinal cord injury. Silk fibroin scaffold can provide a good nerve regeneration microenvironment for amniotic epithelial cells.展开更多
When there is a certain amount of field inhomogeneity,the biased ferrimagnetic crystal can exhibit the higher-order magnetostatic(HMS)mode in addition to the uniform-precession Kittel mode.In cavity magnonics,we show ...When there is a certain amount of field inhomogeneity,the biased ferrimagnetic crystal can exhibit the higher-order magnetostatic(HMS)mode in addition to the uniform-precession Kittel mode.In cavity magnonics,we show the nonlinearity and heating-induced frequency shifts of the Kittel mode and HMS mode in a yttrium-iron-garnet(YIG)sphere.When the Kittel mode is driven to generate a certain number of excitations,the temperature of the whole YIG sample rises and the HMS mode can display an induced frequency shift,and vice versa.This cross effect provides a new method to study the magnetization dynamics and paves a way for novel cavity magnonic devices by including the heating effect as an operational degree of freedom.展开更多
基金supported by the Scientific Research Project Fund of Wuxi Municipal Health and Family Planning Commission,No.MS201402
文摘Treatment and functional reconstruction after central nervous system injury is a major medical and social challenge. An increasing number of researchers are attempting to use neural stem cells combined with artificial scaffold materials, such as fibroin, for nerve repair. However, such approaches are challenged by ethical and practical issues. Amniotic tissue, a clinical waste product, is abundant, and amniotic epithe- lial cells are pluripotent, have low immunogenicity, and are not the subject of ethical debate. We hypothesized that amniotic epithelial cells combined with silk fibroin scaffolds would be conducive to the repair of spinal cord injury. To test this, we isolated and cultured amniotic epithelial cells, and constructed complexes of these cells and silk fibroin scaffolds. Implantation of the cell-scaffold complex into a rat model of spinal cord injury resulted in a smaller glial scar in the damaged cord tissue than in model rats that received a blank scaffold, or amniotic epithelial cells alone. In addition to a milder local immunological reaction, the rats showed less inflammatory cell infiltration at the trans- plant site, milder host-versus-graft reaction, and a marked improvement in motor function. These findings confirm that the transplantation of amniotic epithelial ceils combined with silk fibroin scaffold can promote the repair of spinal cord injury. Silk fibroin scaffold can provide a good nerve regeneration microenvironment for amniotic epithelial cells.
基金Project supported by the National Natural Science Foundation of China(Grants Nos.11934010,U1801661,and 12174329)the Zhejiang Province Program for Science and Technology(Grant No.2020C01019)+1 种基金the Fundamental Research Funds for the Central Universities(Grant No.2021FZZX001-02)the China Postdoctoral Science Foundation(Grant No.2019M660137)
文摘When there is a certain amount of field inhomogeneity,the biased ferrimagnetic crystal can exhibit the higher-order magnetostatic(HMS)mode in addition to the uniform-precession Kittel mode.In cavity magnonics,we show the nonlinearity and heating-induced frequency shifts of the Kittel mode and HMS mode in a yttrium-iron-garnet(YIG)sphere.When the Kittel mode is driven to generate a certain number of excitations,the temperature of the whole YIG sample rises and the HMS mode can display an induced frequency shift,and vice versa.This cross effect provides a new method to study the magnetization dynamics and paves a way for novel cavity magnonic devices by including the heating effect as an operational degree of freedom.
