A one-pot, four-component reaction of ethyl acetoacetate, hydrazine hydrate, aldehydes, and malononitrile was discussed using Lewis acid catalyst morpholine triflate （MorT） to afford a series of dihydropyrano[2,3-c]...A one-pot, four-component reaction of ethyl acetoacetate, hydrazine hydrate, aldehydes, and malononitrile was discussed using Lewis acid catalyst morpholine triflate （MorT） to afford a series of dihydropyrano[2,3-c]pyrazoles, which were generally catalyzed by organic alkalis. Moderate to excellent yields, no chromatographic purification, and evasion of environmentally hazardous solvents in the reaction process make this protocol very useful for academia and industry.展开更多
An efficient two-step method was described for the synthesis of chromeno[3＇,4＇：5,6]pyrano[2,3-blindole derivatives. The three-component reaction of 4-hydroxycoumarin, variously substituted benzaldehydes and indolin...An efficient two-step method was described for the synthesis of chromeno[3＇,4＇：5,6]pyrano[2,3-blindole derivatives. The three-component reaction of 4-hydroxycoumarin, variously substituted benzaldehydes and indolin-2-one was promoted by P205 in refiuxing ethanol to give trimolecular adducts, which were then cyclized in 1,2-dichloroethane under reflux using POCI3.展开更多
A series of substituted 2,3-diaryl-2-azabicyclo[2.2.2]octan-5-ones have been prepared by an efficient three-component aza-Diels-Alder cycloaddition reaction in water catalyzed by layered α-zirconium hydrogen phospha...A series of substituted 2,3-diaryl-2-azabicyclo[2.2.2]octan-5-ones have been prepared by an efficient three-component aza-Diels-Alder cycloaddition reaction in water catalyzed by layered α-zirconium hydrogen phosphate （α-ZrP） and sodium calix[4]arene sulfonates bearing pendant short aliphatic chains. The 18 synthesized compounds were assayed for acetylcholinesterase inhibition using mouse acetvlcho]inesterase.展开更多
文摘A one-pot, four-component reaction of ethyl acetoacetate, hydrazine hydrate, aldehydes, and malononitrile was discussed using Lewis acid catalyst morpholine triflate （MorT） to afford a series of dihydropyrano[2,3-c]pyrazoles, which were generally catalyzed by organic alkalis. Moderate to excellent yields, no chromatographic purification, and evasion of environmentally hazardous solvents in the reaction process make this protocol very useful for academia and industry.
基金the National Natural Science Foundation of China(No.21176222)Zhejiang Key Innovation Team of Green Pharmaceutical Technology for financial support
文摘An efficient two-step method was described for the synthesis of chromeno[3＇,4＇：5,6]pyrano[2,3-blindole derivatives. The three-component reaction of 4-hydroxycoumarin, variously substituted benzaldehydes and indolin-2-one was promoted by P205 in refiuxing ethanol to give trimolecular adducts, which were then cyclized in 1,2-dichloroethane under reflux using POCI3.
基金financial support from the Natural Science Foundation of China(No.21176222)
文摘A series of substituted 2,3-diaryl-2-azabicyclo[2.2.2]octan-5-ones have been prepared by an efficient three-component aza-Diels-Alder cycloaddition reaction in water catalyzed by layered α-zirconium hydrogen phosphate （α-ZrP） and sodium calix[4]arene sulfonates bearing pendant short aliphatic chains. The 18 synthesized compounds were assayed for acetylcholinesterase inhibition using mouse acetvlcho]inesterase.
