Coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome coronavirus 2,poses a significant threat to public health worldwide,and diabetes is considered a risk factor for the rapid progre...Coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome coronavirus 2,poses a significant threat to public health worldwide,and diabetes is considered a risk factor for the rapid progression and poor prognosis of COVID-19.Limited immune function is a clinical feature of COVID-19 patients,and diabetes patients have defects in innate and adaptive immune functions,which may be an important reason for the rapid progression and poor prognosis of COVID-19 in patients with diabetes.We review the possible multiple effects of immune impairment in diabetic patients on the immune responses to COVID-19 to provide guidance for the diagnosis and treatment of diabetic patients with COVID-19.展开更多
Polymer hollow microspheres were prepared by performing alkali treatment on the multilayer core/shell polymer latex particles containing carboxyl groups. Effects of the shell composition and dosage as well as alkali t...Polymer hollow microspheres were prepared by performing alkali treatment on the multilayer core/shell polymer latex particles containing carboxyl groups. Effects of the shell composition and dosage as well as alkali type on the morphology of the microspheres were investigated. Results showed that in comparison with acrylonitrile（AN） and methacrylic acid（MAA）, using butyl acrylate（BA） as the shell co-monomer decreased the glass transition temperature（T_g） of shell effectively and was beneficial to the formation of uniform and big hollow structure. Along with the increase of the shell dosage, the alkali-treated microspheres sequentially presented porous and hollow morphology, and the size of microspheres increased, while the hollow diameter increased first and then decreased, and the maximum hollow ratio reached 39.5%. Furthermore, the multilayer core/shell microspheres had better tolerance to NH_3·H_2O than to NaOH. When the molar ratio of alkali to methacrylic acid（MR_（alkali/acid）） for Na OH ranged from 1.15 to 1.30 or MRalkali/acid for NH_3·H_2O ranged from 1.30 to 2.00, the regular polymer hollow microspheres could be obtained.展开更多
基金Doctoral Research Fund Project of the Second Affiliated Hospital of Anhui Medical University,No.2018BSJJ005Clinical Medicine Discipline Construction Project of Anhui Medical University,No.2021 Lcxk026.
文摘Coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome coronavirus 2,poses a significant threat to public health worldwide,and diabetes is considered a risk factor for the rapid progression and poor prognosis of COVID-19.Limited immune function is a clinical feature of COVID-19 patients,and diabetes patients have defects in innate and adaptive immune functions,which may be an important reason for the rapid progression and poor prognosis of COVID-19 in patients with diabetes.We review the possible multiple effects of immune impairment in diabetic patients on the immune responses to COVID-19 to provide guidance for the diagnosis and treatment of diabetic patients with COVID-19.
基金financially supported by Heilongjiang Provincial Natural Science Foundation for Youth (No. QC2014C052)Fund of Key Laboratory of Advanced Materials of Ministry of Education (No. 2016AML06)
文摘Polymer hollow microspheres were prepared by performing alkali treatment on the multilayer core/shell polymer latex particles containing carboxyl groups. Effects of the shell composition and dosage as well as alkali type on the morphology of the microspheres were investigated. Results showed that in comparison with acrylonitrile（AN） and methacrylic acid（MAA）, using butyl acrylate（BA） as the shell co-monomer decreased the glass transition temperature（T_g） of shell effectively and was beneficial to the formation of uniform and big hollow structure. Along with the increase of the shell dosage, the alkali-treated microspheres sequentially presented porous and hollow morphology, and the size of microspheres increased, while the hollow diameter increased first and then decreased, and the maximum hollow ratio reached 39.5%. Furthermore, the multilayer core/shell microspheres had better tolerance to NH_3·H_2O than to NaOH. When the molar ratio of alkali to methacrylic acid（MR_（alkali/acid）） for Na OH ranged from 1.15 to 1.30 or MRalkali/acid for NH_3·H_2O ranged from 1.30 to 2.00, the regular polymer hollow microspheres could be obtained.
