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Systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis overlap syndrome in a 77-year-old man: A case report 被引量:1
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作者 Zi-Gan Xu wei-long li +6 位作者 Xi Wang Shu-Yuan Zhang Ying-Wei Zhang Xing Wei Chun-Di li Ping Zeng Shao-Dong Luan 《World Journal of Clinical Cases》 SCIE 2021年第3期707-713,共7页
BACKGROUND Systemic lupus erythematosus(SLE)and antineutrophil cytoplasmic antibodyassociated vasculitis(AAV)are classically thought to cause renal impairment and small vessel vasculitis with different pathophysiologi... BACKGROUND Systemic lupus erythematosus(SLE)and antineutrophil cytoplasmic antibodyassociated vasculitis(AAV)are classically thought to cause renal impairment and small vessel vasculitis with different pathophysiologies.Their overlap constitutes a rare rheumatologic disease.To date,only dozens of such cases with biopsyproven glomerulonephritis have been reported worldwide typically in women of childbearing age.Here,we present a unique clinical case due to its rarity and individualized treatment of a Chinese man in his eighth decade of life.CASE SUMMARY A 77-year-old man was admitted to several hospitals for shortness of breath and received nonspecific treatments over the past 3 years.As his symptoms were not completely relieved,he visited our hospital for further treatment.Laboratory examinations revealed kidney dysfunction,severe anaemia,hypocomplementemia,glomerular proteinuria,and microscopic haematuria.Antinuclear antibodies,as well as anti-dsDNA antibodies,were positive.Computed tomography of the chest showed right pleural effusion.Renal biopsy was performed,and histology suggested crescentic glomerulonephritis,pauci-immune type.After treatment with plasmapheresis,glucocorticoid,and cyclophosphamide,the disease was in remission,and the patient remained in a stable condition for over 3 years post-hospital discharge.CONCLUSION Due to its complexity and rarity,SLE and AAV overlap syndrome is easily misdiagnosed.An accurate diagnosis and treatment at the earliest stage may significantly improve the condition and reduce irreversible organ injury. 展开更多
关键词 Systemic lupus erythematosus Antineutrophil cytoplasmic antibodyassociated vasculitis Overlap syndrome Elderly male Renal insufficiency Case report
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Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits in a young woman: A case report
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作者 Zi-Gan Xu wei-long li +6 位作者 Xi Wang Shu-Yuan Zhang Ying-Wei Zhang Xing Wei Chun-Di li Ping Zeng Shao-Dong Luan 《World Journal of Clinical Cases》 SCIE 2021年第10期2357-2366,共10页
BACKGROUND Proliferative glomerulonephritis with monoclonal immunoglobulin G(IgG)deposits(PGNMID)is a newly recognized rare disease.The renal pathology is characterized by prominent manifestations of membranous hyperp... BACKGROUND Proliferative glomerulonephritis with monoclonal immunoglobulin G(IgG)deposits(PGNMID)is a newly recognized rare disease.The renal pathology is characterized by prominent manifestations of membranous hyperplasia,which are easy to misdiagnose.The clinical symptoms are severe.Massive proteinuria and hypoproteinemia are conspicuous,and most patients are accompanied by renal insufficiency and microscopic hematuria.CASE SUMMARY A 27-year-old woman was admitted to a hospital for macroscopic hematuria and proteinuria 4 years prior,and renal biopsy in the hospital suggested moderate-tosevere mesangial proliferating glomerulonephritis(MsPGN).She had taken a glucocorticoid,cyclophosphamide,mycophenolate mofetil,and other treatments and achieved brief partial remission.Recently,the patient visited our hospital due to massive proteinuria.Repeated renal biopsy and re-evaluation of the first biopsy obtained 4 years previously revealed monoclonal immunoglobulin deposition in the glomeruli.A bone marrow examination was performed to exclude hematologic malignancy,and a diagnosis of PGNMID was established.The patient showed remission after four cycles of a bortezomib+cyclophosphamide+dexamethasone scheme.CONCLUSION PGNMID is usually misdiagnosed as MsPGN or membranoproliferative glomerulonephritis.Although it often occurs in middle-aged and elderly individuals,it cannot be readily excluded in young people,even when serum immunofixation electrophoresis is negative.IgG subtype and light chain staining are necessary when this disease is highly suspected.An accurate diagnosis at the earliest stage may avoid the overuse of glucocorticoids and immunosuppressants. 展开更多
关键词 Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits Renal insufficiency Second renal biopsy Young female BORTEZOMIB Case report
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Goodpasture syndrome and hemorrhage after renal biopsy: A case report 被引量:2
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作者 wei-long li Xi Wang +6 位作者 Shu-Yuan Zhang Zi-Gan Xu Ying-Wei Zhang Xing Wei Chun-Di li Ping Zeng Shao-Dong Luan 《World Journal of Clinical Cases》 SCIE 2020年第2期404-409,共6页
BACKGROUND Goodpasture syndrome(GS) is a rare disease, the morbidity of which is estimated to be 0.5-0.8 per million per year. Hemorrhage is the most serious complication in renal biopsy. Despite the fact that both GS... BACKGROUND Goodpasture syndrome(GS) is a rare disease, the morbidity of which is estimated to be 0.5-0.8 per million per year. Hemorrhage is the most serious complication in renal biopsy. Despite the fact that both GS and hemorrhage after renal biopsy are rare, it has not been reported that they are likely to occur in the same patient.CASE SUMMARY A 30-year-old man with diffuse pulmonary hemorrhage and rapid progressive renal function caused by anti-glomerular basement membrane disease presented atypical symptoms without hemoptysis, accompanied by life-threatening hypoxemia. Plasmapheresis was performed, and glucocorticoids and cyclophosphamide were administered. The patient started to show signs of improvement. Percutaneous renal biopsy is an appropriate diagnostic measure that is commonly safe, but this patient experienced hemorrhage after operation,thus necessitating embolization of the renal artery to stop the bleeding. The patient’s condition was improved, and the serum anti-glomerular basement membrane antibody level was 106 AU/m L(normal range: < 24 AU/m L) and slowly decreased. His discharge medications were oral daily prednisone(30 mg)and continued maintenance hemodialysis.CONCLUSION GS is a rare organ-specific autoimmune disease that is invariably ubiquitous in the lung and kidney areas. Renal biopsy is the appropriate procedure for the treatment of GS disease, although it is an invasive measure. 展开更多
关键词 Goodpasture disease Anti-glomerular basement membrane disease Renal biopsy HEMORRHAGE Glomerular basement membrane Case report
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Transverse emittance measurement for the heavy ion medical machine cyclotron
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作者 Yong-Chun Feng Min li +10 位作者 Rui-Shi Mao Bing Wang Sheng-Peng li wei-long li Wei-Nian Ma Xin-Cai Kang Jin-Quan Zhang Peng li Tie-Cheng Zhao Zhi-Guo Xu You-Jin Yuan 《Nuclear Science and Techniques》 SCIE CAS CSCD 2019年第12期103-110,共8页
The transverse emittance of the extracted beam from the heavy ion medical machine cyclotron is measured and then optimized for injection into the synchrotron.For the purposes of cross-validation,three methods,i.e.,sli... The transverse emittance of the extracted beam from the heavy ion medical machine cyclotron is measured and then optimized for injection into the synchrotron.For the purposes of cross-validation,three methods,i.e.,slit-grid,Q-scan,and 3-grid,are used to measure the emittance.In the slit-grid technique,an automatic selection of the region of interest is adopted to isolate the major noise from the beam phase space,which is an improvement over the traditional technique.After iterating over the contour level,an unbiased measurement of the emittance can be obtained.An improvement in the thin lens technique is implemented in the Q-scan method.The results of these measurements are presented. 展开更多
关键词 Heavy ion MEDICAL MACHINE TRANSVERSE EMITTANCE Slit-grid
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