A pentamodule assembly approach has been established for total synthesis of the naturally occurring(-)-palmyrolide A and(+)-5,7-epi-palmyrolide A.By using the racemic tert-butyl carbinol-containing alkyl iodide,the tw...A pentamodule assembly approach has been established for total synthesis of the naturally occurring(-)-palmyrolide A and(+)-5,7-epi-palmyrolide A.By using the racemic tert-butyl carbinol-containing alkyl iodide,the two diastereoisomeric macrolides could be obtained from the same sequence of reactions,demonstrating the flexibility of the multimodule assembly strategy for diverted total synthesis.展开更多
A concise total synthesis of amphidinin B, a cytotoxic linear dicarboxylic acid associated with amphidinolide T marine macrolides, has been accomplished from the 19-membered cycloalkene intermediates designed for dive...A concise total synthesis of amphidinin B, a cytotoxic linear dicarboxylic acid associated with amphidinolide T marine macrolides, has been accomplished from the 19-membered cycloalkene intermediates designed for diverted total synthesis of amphidinolide T1 and T3-T5. The lH and 13C NMR spectra of the synthesized amphidinin B in C6D6 and CDC13 were compared with those for the natural and synthetic forms reported in the literature, showing solvent-dependence of the ^1H and ^13C NMR signals of amphidinin B in C6D6 and CDC13.展开更多
基金This work is supported in part by a General Research Fund grant(601211)from the Research Grant CouncilThe Hong Kong Special Administrative Region,P.R.China+1 种基金The Hong Kong Chiu Chow Chamber of Commence HKUST Scholarship for Ph.D.Study(Y.L.)the Department of Chemistry,HKUST.
文摘A pentamodule assembly approach has been established for total synthesis of the naturally occurring(-)-palmyrolide A and(+)-5,7-epi-palmyrolide A.By using the racemic tert-butyl carbinol-containing alkyl iodide,the two diastereoisomeric macrolides could be obtained from the same sequence of reactions,demonstrating the flexibility of the multimodule assembly strategy for diverted total synthesis.
文摘A concise total synthesis of amphidinin B, a cytotoxic linear dicarboxylic acid associated with amphidinolide T marine macrolides, has been accomplished from the 19-membered cycloalkene intermediates designed for diverted total synthesis of amphidinolide T1 and T3-T5. The lH and 13C NMR spectra of the synthesized amphidinin B in C6D6 and CDC13 were compared with those for the natural and synthetic forms reported in the literature, showing solvent-dependence of the ^1H and ^13C NMR signals of amphidinin B in C6D6 and CDC13.
