Information Flow Scheduling in Concurrent Multi-Product Development Based on DSM

Multi-product collaborative development is adopted widely in manufacturing enterprise, while the present multi-project planning models don＇t take techni- cal/data interactions of multiple products into account. To decrease the influence of technical/data interactions on project progresses, the information flow scheduling models based on the extended DSM is presented. Firstly, infor- mation dependencies are divided into four types： series, parallel, coupling and similar. Secondly, different types of dependencies are expressed as DSM units, and the exten- ded DSM model is brought forward, described as a block matrix. Furthermore, the information flow scheduling methods is proposed, which involves four types of opera- tions, where partitioning and clustering algorithm are modified from DSM for ensuring progress of high-priority project, merging and converting is the specific computation of the extended DSM. Finally, the information flow scheduling of two machine tools development is analyzed with example, and different project priorities correspond to different task sequences and total coordination cost. The proposed methodology provides a detailed instruction for information flow scheduling in multi-product development, with specially concerning technical/data interactions.

Sticking-bacteria gel enhancing anti-multidrug-resistant microbial therapy under ultrasound

The use of antibiotic could cause severe drug-resistance and the increasing spread of pathogenic drug-resistant bacteria has brought a big threat to human health,hence,some innovative methods inspired,such as sonodynamic therapy,have become increasingly attractive for realizing the antibiotic-free methods against bacterial infection.However,many pathogens can invade normal healthy cells to establish intracellular replicative niches,which makes it more difficult to kill and remove these bacteria.Herein,inspired by respiratory mucus trapping bacteria to kill them,we developed a novel gel of amorphous TiO_(x) nanofibers dotted with Ti_(2)C(OH)_(2) nanosheets,which could capture and trap bacteria into the gel via a strong binding ability toward bacteria by forming a Ti–O–P bond between phosphate in the bacterial wall and Ti-OH in the gel,thereby,efficiently blocking the invasions of bacteria.Also,the gel has excellent ability for generating reactive oxygen species(ROS)under ultrasound irradiation,therefore,the bacteria in the gel could be effectively killed by the ROS produced under ultrasound irradiation.Moreover,Ti2C(OH)2 in the gel was able to scavenge H_(2)O_(2),and transfer it into O_(2) in the infection environment,providing enough O_(2) for sonodynamic therapy.The experimental results have demonstrated that the functional gel obviously accelerated the healing of multidrug-resistant microorganisms-infected wounds.