An efficient construction of oxazoline-containing polycyclic scaffolds is presented through a Pd-catalyzed addition/cyclization of(hetero)arene tethered O-acyl cyanohydrin units and arylboronic acids.Diverse oxazoline...An efficient construction of oxazoline-containing polycyclic scaffolds is presented through a Pd-catalyzed addition/cyclization of(hetero)arene tethered O-acyl cyanohydrin units and arylboronic acids.Diverse oxazoline-containing polycyclic compounds can be prepared in good to high yields under mild reaction conditions.This method can be extended to prepare multi-substituted polycyclic heterocyclic compounds via a Pd-catalyzed addition/cyclization/arylation tandem sequence using arylboronic acid and different heteroarene scaffolds such as thiophene,pyrrole and furan analogues.展开更多
基金The NSFC(no.21772063)the Open Project of State Key Laboratory for Supramolecular Structure and Materials(sklssm2021010)are acknowledged.
文摘An efficient construction of oxazoline-containing polycyclic scaffolds is presented through a Pd-catalyzed addition/cyclization of(hetero)arene tethered O-acyl cyanohydrin units and arylboronic acids.Diverse oxazoline-containing polycyclic compounds can be prepared in good to high yields under mild reaction conditions.This method can be extended to prepare multi-substituted polycyclic heterocyclic compounds via a Pd-catalyzed addition/cyclization/arylation tandem sequence using arylboronic acid and different heteroarene scaffolds such as thiophene,pyrrole and furan analogues.
