Deuteron-driven spallation targets have garnered attention recently because they can provide high-energy neutrons to transmute long-lifetime fission products.In this study,the Geant4 toolkit was used to simulate the i...Deuteron-driven spallation targets have garnered attention recently because they can provide high-energy neutrons to transmute long-lifetime fission products.In this study,the Geant4 toolkit was used to simulate the inter-action between a deuteron beam at 500 MeV and a com-posite target composed of alternating lead-bismuth eutectic(LBE)and water.The water was used because it may be employed as a target coolant.The energy spectrum,neu-tron yield,average energy,and total energy of the emitted neutrons were calculated for different thicknesses and thickness ratios between the LBE and water.For a constant target thickness,the neutron yield increases with an increasing thickness ratio of LBE to H 2 O,while the aver-age energy of the emitted neutrons decreases with an increasing in the aforementioned thickness ratio.These two aspects support the use of a pure target,either LBE or water.However,with an increasing LBE-to-H 2 O thickness ratio,the total energy of the emitted neutrons increases and then decreases.This result supports the addition of water into the LBE target.The angular distributions of the emitted neutrons show that the rear of the target is suit-able for loading nuclear waste containing minor actinides and long-lifetime fission products.展开更多
Objective:To explore the effect of nicorandil on the coronary artery microcirculation and hemodynamics in patients with coronary slow flow (CSF).Methods: A total of 86 patients with CSF who were admitted in our hospit...Objective:To explore the effect of nicorandil on the coronary artery microcirculation and hemodynamics in patients with coronary slow flow (CSF).Methods: A total of 86 patients with CSF who were admitted in our hospital were included in the study and randomized into the treatment group and the control group with 43 cases in each group. The patients in the control group were given aspirin, HMG-CoA reductase inhibitor, and ACEI. On this basis, the patients in the treatment group were given nicorandil. The patients in the two groups were continuously treated for 6 months. The coronary artery microcirculation and hemodynamic indicators before and after treatment in the two groups were detected and compared.Results:TAT, ET-1, and hs-CRP levels, LAD, LCX, RCA, TIMI average blood flow frame count value, and IMR after treatment in the two groups were significantly reduced when compared with before treatment (P<0.05). The above indicators after treatment in the treatment group were significantly lower than those in the control group (P<0.05). FMD after treatment in the two groups was significantly elevated when compared with before treatment (P<0.05). FMD after treatment in the treatment group was significantly higher than that in the control group (P<0.05). Conclusions: Nicorandil in the treatment of CSF can effectively improve the coronary artery microcirculation and hemodynamics, with a significant efficacy.展开更多
基金supported by the National Natural Science Foundation of China(No.11875328).
文摘Deuteron-driven spallation targets have garnered attention recently because they can provide high-energy neutrons to transmute long-lifetime fission products.In this study,the Geant4 toolkit was used to simulate the inter-action between a deuteron beam at 500 MeV and a com-posite target composed of alternating lead-bismuth eutectic(LBE)and water.The water was used because it may be employed as a target coolant.The energy spectrum,neu-tron yield,average energy,and total energy of the emitted neutrons were calculated for different thicknesses and thickness ratios between the LBE and water.For a constant target thickness,the neutron yield increases with an increasing thickness ratio of LBE to H 2 O,while the aver-age energy of the emitted neutrons decreases with an increasing in the aforementioned thickness ratio.These two aspects support the use of a pure target,either LBE or water.However,with an increasing LBE-to-H 2 O thickness ratio,the total energy of the emitted neutrons increases and then decreases.This result supports the addition of water into the LBE target.The angular distributions of the emitted neutrons show that the rear of the target is suit-able for loading nuclear waste containing minor actinides and long-lifetime fission products.
文摘Objective:To explore the effect of nicorandil on the coronary artery microcirculation and hemodynamics in patients with coronary slow flow (CSF).Methods: A total of 86 patients with CSF who were admitted in our hospital were included in the study and randomized into the treatment group and the control group with 43 cases in each group. The patients in the control group were given aspirin, HMG-CoA reductase inhibitor, and ACEI. On this basis, the patients in the treatment group were given nicorandil. The patients in the two groups were continuously treated for 6 months. The coronary artery microcirculation and hemodynamic indicators before and after treatment in the two groups were detected and compared.Results:TAT, ET-1, and hs-CRP levels, LAD, LCX, RCA, TIMI average blood flow frame count value, and IMR after treatment in the two groups were significantly reduced when compared with before treatment (P<0.05). The above indicators after treatment in the treatment group were significantly lower than those in the control group (P<0.05). FMD after treatment in the two groups was significantly elevated when compared with before treatment (P<0.05). FMD after treatment in the treatment group was significantly higher than that in the control group (P<0.05). Conclusions: Nicorandil in the treatment of CSF can effectively improve the coronary artery microcirculation and hemodynamics, with a significant efficacy.
