Directed transport of coupled Brownian motors in a two-dimensional traveling-wave potential

Considering an elastically coupled Brownian motors system in a two-dimensional traveling-wave potential, we investigate the effects of the angular frequency of the traveling wave, wavelength, coupling strength, free length of the spring, and the noise intensity on the current of the system. It is found that the traveling wave is the essential condition of the directed transport. The current is dominated by the traveling wave and varies nonmonotonically with both the angular frequency and the wavelength. At an optimal angular frequency or wavelength, the current can be optimized. The coupling strength and the free length of the spring can locally modulate the current, especially at small angular frequencies. Moreover, the current decreases rapidly with the increase of the noise intensity, indicating the interference effect of noise on the directed transport.

Effect of Yangxinshi Tablets on the Phenotype and Function of Monocytes in Patients with Unstable Angina Pectoris of Coronary Heart Disease

Objective:The objective of this study was to observe the effect of Yangxinshi tablets on the phenotype and function of peripheral blood monocytes in patients with unstable angina of coronary heart disease(CHD)and to explore the possible mechanism of Yangxinshi tablets in the treatment of CHD.Methods:A total of 100 patients with unstable angina of CHD were randomly divided into two groups:Group A–treatment group and Group B–control group.The phenotypic and functional changes in blood monocytes and the changes in serum inflammatory factors before and after treatment were compared in the two groups.Results:The expression of CD14^+CD163^+interleukin(IL)-10^+was significantly higher in the control group than in the patients with unstable angina of CHD,whereas the expression of CD14^+CD163-IL-12^+was lower.The concentration of IL-10 was higher in the control group than in the patients with unstable angina,whereas the concentration of tumor necrosis factor-α(TNF-α)and IL-12 was significantly lower.In Group A,the expression of CD14^+CD163^+,CD14^+CD206^+,and CD14^+CD163^+CD206^+in peripheral blood monocytes increased after treatment than before treatment,whereas the expression of CD14^+CD163-CD206-decreased.The expression of CD14^+CD163-IL-12^+decreased after treatment than before,whereas CD14^+CD163^+IL-10^+expression increased.The serum concentration of IL-10 in Group A was higher after treatment than before,whereas that of IL-12 and TNF-αwas lower.In Group B,the phenotype and function of the peripheral blood monocytes remained unchanged.Conclusion:Yangxinshi tablet therapy can change the phenotype of the peripheral blood monocytes in patients with unstable angina of CHD.Yangxinshi tablet therapy changes the inflammatory state in patients with an increase in the expression of anti-inflammatory factors and a decrease in the expression of inflammatory factors.

Rotation-translation coupling of a double-headed Brownian motor in a traveling-wave potential

Considering a double-headed Brownian motor moving with both translational and rotational degrees of freedom,we investigate the directed transport properties of the system in a traveling-wave potential.It is found that the traveling wave provides the essential condition of the directed transport for the system,and at an appropriate angular frequency,the positive current can be optimized.A general current reversal appears by modulating the angular frequency of the traveling wave,noise intensity,external driving force and the rod length.By transforming the dynamical equation in traveling-wave potential into that in a tilted potential,the mechanism of current reversal is analyzed.For both cases of Gaussian and Lévy noises,the currents show similar dependence on the parameters.Moreover,the current in the tilted potential shows a typical stochastic resonance effect.The external driving force has also a resonance-like effect on the current in the tilted potential.But the current in the traveling-wave potential exhibits the reverse behaviors of that in the tilted potential.Besides,the currents obviously depend on the stability index of the Lévy noise under certain conditions.