The purpose of this study was to detect changes in urine of mice and to clarify the toxicity induced by bupleurotoxin(BETX) using liquid chromatography/quadrupole time-of-flight mass spectrometry(LC-Q-TOF-MS). A proce...The purpose of this study was to detect changes in urine of mice and to clarify the toxicity induced by bupleurotoxin(BETX) using liquid chromatography/quadrupole time-of-flight mass spectrometry(LC-Q-TOF-MS). A procedure for urine analysis using pattern recognition was proposed to evaluate the toxicity induced by BETX in male BALB/c mice. BETX at 2.5 mg/kg was administrated intraperitoneally(i.p.), and urine samples for the metabolomic study were collected from control and BETX experimental groups. Changes in the concentrations of some urine metabolites were detected exclusively in the experimental group. All results suggested that exposure to BETX might cause a disturbance in fatty acid metabolism and the oxidative stress system. These results may not only clarify the underlying mechanism of diverse intoxication effects of BETX but also provide the guidance in preclinical toxicity screening for new drugs.展开更多
Slag is the heart of electroslag remelting(ESR)process.A new mathematical model to design the optimized slag for ESR was developed based on slag–metal equilibrium theory,ion and molecule coexistence theory and modifi...Slag is the heart of electroslag remelting(ESR)process.A new mathematical model to design the optimized slag for ESR was developed based on slag–metal equilibrium theory,ion and molecule coexistence theory and modified Butler’s equation.It was assumed that an overall thermodynamic equilibrium did exist at electrode tip–slag interface.With this model,the equilibrium slag and its surface tension could be obtained quantitatively when the initial compositions of consumable electrode were given.An industrial experiment with four types of slags was carried out in a special steel plant in China.The variation of Al,Si and Mn corresponded well with the deviation of corresponding oxide from equilibrium,reflecting the reasonability of the model.Besides that,the effects of Al in electrode as well as CaO,CaF2 and MgO in slag on the equilibrium slag,dissolved oxygen and surface tension were discussed in detail.展开更多
基金supported by a program of the NCET Foundation,NSFC(81402823)partially supported by the Global Research Network for Medicinal Plants(GRNMP)+6 种基金by King Saud University,Shanghai Leading Academic Discipline Project(B906)FP7-PEOPLE-IRSES-2008(TCMCANCER Project 230232)the Key laboratory of drug research for special environments,PLAthe Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(10DZ2251300)the Scientific Foundation of Shanghai China(09DZ1975700,09DZ1971500,10DZ1971700)the National Major Project of China(2011ZX09307-002-03)the National Key Technology R&D Program of China(2012BAI29B06)
文摘The purpose of this study was to detect changes in urine of mice and to clarify the toxicity induced by bupleurotoxin(BETX) using liquid chromatography/quadrupole time-of-flight mass spectrometry(LC-Q-TOF-MS). A procedure for urine analysis using pattern recognition was proposed to evaluate the toxicity induced by BETX in male BALB/c mice. BETX at 2.5 mg/kg was administrated intraperitoneally(i.p.), and urine samples for the metabolomic study were collected from control and BETX experimental groups. Changes in the concentrations of some urine metabolites were detected exclusively in the experimental group. All results suggested that exposure to BETX might cause a disturbance in fatty acid metabolism and the oxidative stress system. These results may not only clarify the underlying mechanism of diverse intoxication effects of BETX but also provide the guidance in preclinical toxicity screening for new drugs.
基金The authors wish to express their gratitude to Xining Special Steel Plant,Chinathe National Natural Science Foundation of China(Grant Nos.51874034 and 51674024)for their financial support.
文摘Slag is the heart of electroslag remelting(ESR)process.A new mathematical model to design the optimized slag for ESR was developed based on slag–metal equilibrium theory,ion and molecule coexistence theory and modified Butler’s equation.It was assumed that an overall thermodynamic equilibrium did exist at electrode tip–slag interface.With this model,the equilibrium slag and its surface tension could be obtained quantitatively when the initial compositions of consumable electrode were given.An industrial experiment with four types of slags was carried out in a special steel plant in China.The variation of Al,Si and Mn corresponded well with the deviation of corresponding oxide from equilibrium,reflecting the reasonability of the model.Besides that,the effects of Al in electrode as well as CaO,CaF2 and MgO in slag on the equilibrium slag,dissolved oxygen and surface tension were discussed in detail.
