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心肺复苏时呼吸机高压报警上限与吸气触发灵敏度合理设置的临床研究 被引量:5
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作者 王伟钟 姚晓燕 +2 位作者 徐唯超 石祝君 马红丽 《中国现代医学杂志》 CAS 北大核心 2021年第3期80-83,共4页
目的观察心肺复苏时呼吸机不同高压报警上限和吸气触发灵敏度设置对复苏效果的影响,探讨心肺复苏时合理的高压报警上限和吸气触发灵敏度设置,提高心肺复苏效果。方法选取2015年12月-2018年12月绍兴市人民医院收治的53例心肺复苏患者,采... 目的观察心肺复苏时呼吸机不同高压报警上限和吸气触发灵敏度设置对复苏效果的影响,探讨心肺复苏时合理的高压报警上限和吸气触发灵敏度设置,提高心肺复苏效果。方法选取2015年12月-2018年12月绍兴市人民医院收治的53例心肺复苏患者,采用随机数字表法分为A组27例和B组26例。A组高压报警上限设置为80 cmH2O,吸气触发灵敏度选择压力触发-20 cmH2O;B组按常规设置,高压报警上限设置为35 cmH2O,吸气触发灵敏度选择流量触发3。监测两组2 min、10 min、20 min、30 min时呼出潮气量、呼吸频率、呼气末二氧化碳分压(PETCO2)及动脉血氧分压(PaO2),并比较两组复苏成功率。结果 A组不同时间点呼出潮气量、PETCO2、PaO2高于B组(P<0.05);而各时间点呼吸频率低于B组(P<0.05)。A组30min时复苏成功率高于B组(P<0.05)。结论高压报警上限设置为80 cmH2O,触发选择压力触发-20 cmH2O可提高心肺复苏的疗效。 展开更多
关键词 心脏病 心脏停搏 心肺复苏术 通气机 机械 对比研究
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Expression of NGF family and their receptors in gastric carcinoma:A cDNA microarray study 被引量:5
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作者 Jian-JunDu Ke-FengDou +8 位作者 Shu-YouPeng Bing-ZhiQian, Hua-ShengXiao FengLiu wei-zhongwang Wen-XianGuan Zhi-QingGao Ying-BinLiu, Ze-GuangHan 《World Journal of Gastroenterology》 SCIE CAS CSCD 2003年第7期1431-1434,共4页
AIM: To investigate the expression of NGF family and their receptors in gastric carcinoma and normal gastric mucosa,and to elucidate their effects on gastric carcinoma.METHODS: RNA of gastric cancer tissues and normal... AIM: To investigate the expression of NGF family and their receptors in gastric carcinoma and normal gastric mucosa,and to elucidate their effects on gastric carcinoma.METHODS: RNA of gastric cancer tissues and normal gastric tissues was respectively isolated and mRNA was purified.Probes of both mRNA reverse transcription product cDNAs labled with α-33P dATP were respectively hybridized with Atlas Array membrane where NGF and their family genes were spotted on. Hybridized signal images were scanned on phosphor screen with ImageQuant 5.1 software after hybridization. Normalized values on spots were analyzed with ArrayVersion 5.0 software. Differential expression of NGF family and their receptors mRNA was confirmed between hybridized Atlas Array membranes of gastric cancer tissues and normal gastric mucosa, then their effects on gastric carcinoma were investigated.RESULTS: Hybridization signal images on Atlas Array membrane appeared in a lower level of nonspecific hybridization. Both of NGF family and their receptors Trk family mRNA were expressed in gastric cancer and normal gastric mucosa. But adversely up-regulated expression in other tissues and organs. NGF, BDGF, NT-3, NT-4/5, NT-6and TrkA, B and C were down-regulated simultaneously in gastric carcinoma in comparison with normal gastric mucosa. Degrees of down-regulation in NGF family were greater than those in their receptors Trk family. Downregulation of NT-3 and BDGF was the most significant,and TrkC down-regulation level was the lowest in receptors Trk family.CONCLUSION: Down-regulated expression of NGF family and their receptors Trk family mRNA in gastric cancer is confirmed. NGF family and their receptors Trk family probably play a unique role in gastric cancer cell apoptosis by a novel Ras or Raf signal transduction pathway. Their synchronous effects are closely associated with occurrence and development of gastric carcinoma induced by reduction of signal transduction of programmed cell death. 展开更多
关键词 胃癌 CDNA微阵列 NGF 信号转导 细胞凋亡
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