Kinsenoside:A Promising Bioactive Compound from Anoectochilus Species

Kinsenoside is a main active component isolated from plants of the genus Anoectochilus,and exhibits many biological activities and pharmacological effects,including hepatoprotective,anti-hyperglycemic,anti-hyperliposis,anti-inflammatory,vascular protective and anti-osteoporosis effects and so on,which is contributing to its promising potency in disease treatments.This review aims to recapitulate the pharmacological functions of kinsenoside,as well as its source,extraction,identification,quantitative analysis,pharmacokinetics,synthesis and patent information.The data reported in this work can confirm the therapeutic potential of kinsenoside and provide useful information for further new drug development.

原发性肝癌切除术中联合残肝断面射频消融对术后局部复发的预防

背景手术切除是可能治愈肝癌的主要方法,小肝癌的射频消融治疗也能达到手术切除的相同效果,但术后的高复发率很大程度上制约了其治疗效果,为预防或减少术后肝断面的局部复发,我们设计了本联合处理方法,初步效果良好.目的为探讨原发性肝癌切除手术中残肝断面处理的新方法对患者术后肿瘤局部复发的预防作用.方法回顾2016-10/2019-09期间17例原发性肝癌切除术中联合残肝断面使用射频消融(腹腔镜手术8例,开腹手术9例)患者的临床资料,分析其术后肿瘤局部复发情况.结果所有患者无严重术后并发症,术后每3 mo随访复查,已坚持随访6-36 mo,中位随访时间25.7 mo±4.4 mo,所有患者残肝断面局部无复发;术后15 mo腹腔淋巴结转移1例,术后18 mo远离肝断面的新发肝内癌灶1例,这2例患者均采用现代中西医结合模式进一步治疗,现带瘤生存良好,其他患者状况良好,全组无死亡.结论原发性肝癌切除术中应用射频消融处理残肝断面可显著降低肿瘤局部复发,在提高患者生存方面有积极的临床意义,值得临床推广应用.