Practice and Exploration of Economic Benefit Evaluation of Medical Equipment in Our Hospital

Objective The evaluation index of medical equipment's economic benefit is based on the usage of medical equipment,the traditional data collection method is time-consuming,laborious and not entirely accurate.The usage of medical equipment is obtained by designing data query statements from the HIS system.Methods First the charging items are in correspondence with the device's name included,second fees and other relevant data are extracted from charging module in HIS.Through a rough estimate of the recovery period and an increase or decrease ratio,the economic benefit of the medical equipment can be analyzed.Results Through the method of the benefit analysis of the medical equipment,we can clearly find out the different economic benefit of the equipment,and finally analyze the reasons.Conclusion Practice has proved that,this methad,it can greatly reduce human,material resources required in data collection and improve the accuracy of the data.It can help hospital managers timely to grasp the operating costs of medical equipment and other information,and also provide scientific data for hospital managers when they purchase reasonable medical equipment.

Iterative filtered ghost imaging

It is generally believed that,in ghost imaging,there has to be a compromise between resolution and visibility.Here we propose and demonstrate an iterative filtered ghost imaging scheme whereby a super-resolution image of a grayscale object is achieved,while at the same time the signal-to-noise ratio(SNR)and visibility are greatly improved,without adding complexity.The dependence of the SNR,visibility,and resolution on the number of iterations is also investigated and discussed.Moreover,with the use of compressed sensing the sampling number can be reduced to less than 1%of the Nyquist limit,while maintaining image quality with a resolution that can exceed the Rayleigh diffraction bound by more than a factor of 10.

Super-resolution filtered ghost imaging with compressed sensing

A filtered ghost imaging(GI)protocol is proposed that enables the Rayleigh diffraction limit to be exceeded in an intensity correlation system;a super-resolution reconstructed image is achieved by low-pass filtering of the measured intensities.In a lensless GI experiment performed with spatial bandpass filtering,the spatial resolution can exceed the Rayleigh diffraction bound by more than a factor of 10.The resolution depends on the bandwidth of the filter,and the relationship between the two is investigated and discussed.In combination with compressed sensing programming,not only high resolution can be maintained but also image quality can be improved,while a much lower sampling number is sufficient.

Chimeric protein probes for C5a receptors through fusion of the anaphylatoxin C5a core region with a small-molecule antagonist

Blockade of the interaction of anaphylatoxin C5a with its receptor C5aR1 has been actively studied as a potential treatment for many inflammatory diseases;but current C5a antagonists exhibit inadequate potency and poor species cross-reactivity, and novel biochemical tools are needed to investigate whether the core region of C5a contains important interaction epitopes that can explain these limitations. Herein, we report the development of chimeric protein C5a probes containing both the complete core region of rat or human C5a, and the small-molecule antagonist PMX53-1. These probes were chemically synthesized through hydrazide-based native chemical ligation of a linear peptide hydrazide with the requisite cyclopeptidic antagonist, both of which were made by solid-phase synthesis. Quasi-racemic X-ray crystallography established that attachment of PMX53-1 did not affect the structure of the core region of C5a. Subsequent C5aR1 activity assays demonstrated the probes can provide valuable insights into the development of C5a antagonists;for example, they exhibited significantly better binding affinity and much improved species cross-reactivity than PMX53-1, supporting the notion that the effect of some epitopes outside the C-terminus of C5a should be taken into consideration when designing better C5a antagonists. Surprisingly, the core region of C5a was found to partially agonize C5aR1, suggesting the presence of more than one agonistic interaction in the binding of C5a to C5aR1. This study exemplifies the value of chemical protein synthesis in developing novel receptor probes for drug discovery research.

镜像蛋白信息编码与存储技术

生物大分子用于信息存储和编码近年来受到广泛关注.本文报道了一种基于镜像蛋白的信息编码与存储方法.该方法以D-氨基酸作为信息编码与存储的基本结构单元,利用蛋白化学合成技术得到含编码信息镜像蛋白材料,并通过物理掺杂等方式将信息存储于目标物件中;通过生物素-链霉亲和素树脂介导的特异性富集从目标物件中提取镜像蛋白,并使用Ni(Ⅱ)介导的镜像蛋白序列选择性切割得到信息编码的多肽;通过LC-MS/MS测序技术实现了信息解析,最后转码还原为原始信息.使用镜像蛋白信息编码与存储技术,本文将多个汉字编码为镜像蛋白,存储至聚对苯二甲酸乙二酯(PET)薄膜中,并通过镜像蛋白信息材料富集提取、LC-MS/MS测序等操作,最后解码得到原始信息.相比于天然生物大分子作为信息编码与存储材料,本文报道的镜像蛋白具有稳定性好、持久耐用等优点.