AIM： To investigate the effect of Helicobacter pylori （H pylon） infection on Bax protein expression, and explore the role of Hpyloriin gastric carcinogenesis. METHODS： Hpyloriwas assessed by rapid urease test and ...AIM： To investigate the effect of Helicobacter pylori （H pylon） infection on Bax protein expression, and explore the role of Hpyloriin gastric carcinogenesis. METHODS： Hpyloriwas assessed by rapid urease test and Warthin-Starry method, and expression of Bax protein was examined immunohistochemically in 72 patients with pre-malignant lesions. RESULTS： Bax protein was differently expressed in intestinal metaplasia and gastric dysplasia, and showed 63.99% positivity. The positivity of Bax protein expression in Hpylori-positive gastric precancerous lesions （72.3%） was significantly higher than that in H pylori-negative gastric precancerous lesions （48.0%, x^2= 4.191, P〈0.05）. Hpyloriinfection was well correlated with the expression of Bax protein in gastric precancerous lesions （r= 0.978, P〈0.01）. After eradication of H pylori, the positivity of Bax protein expression significantly decreased in Hpylori-positive gastric precancerous lesions （x^2 = 5.506, P〈0.05）. In the persisting H pylori-infected patients, the positivity of Bax protein expression was not changed. CONCLUSION： H pyloriinfection may be involved in the upregulation of Bax gene, which might be one of the mechanisms of Hpyloriinfection-induced gastric epithelial cell apoptosis. Hpylorimight act as a tumor promoter in the genesis of gastric carcinoma and eradication of Hpylori could inhibit gastric carcinogenesis.展开更多
A grating eddy current displacement sensor(GECDS) can be used in a watertight electronic transducer to realize long range displacement or position measurement with high accuracy in difficult industry conditions.The pa...A grating eddy current displacement sensor(GECDS) can be used in a watertight electronic transducer to realize long range displacement or position measurement with high accuracy in difficult industry conditions.The parameters optimization of the sensor is essential for economic and efficient production.This paper proposes a method to combine an artificial neural network(ANN) and a genetic algorithm(GA) for the sensor parameters optimization.A neural network model is developed to map the complex relationship between design parameters and the nonlinearity error of the GECDS,and then a GA is used in the optimization process to determine the design parameter values,resulting in a desired minimal nonlinearity error of about 0.11%.The calculated nonlinearity error is 0.25%.These results show that the proposed method performs well for the parameters optimization of the GECDS.展开更多
The grating eddy current displacement sensor (GECDS) for distance or position measurement used in watertight electronic calipers was described. The sensor relies on repetitive variation of inductance against displacem...The grating eddy current displacement sensor (GECDS) for distance or position measurement used in watertight electronic calipers was described. The sensor relies on repetitive variation of inductance against displacement caused by the change of coupling areas between moving coils and static reflectors. The investigations focused on setting up and utilizing a computer model of the 3D eddy current fields and geometry to analyze causes of the production of measurement blind areas, and to investigate effects of the sensor parameters, such as axial gap between coils and reflectors, reflector length and reflector width on characteristics of the sensor. Simulation results indicated that the sensor has the smallest nonlinearity error of 0.15%, which agrees well with the experimental results.展开更多
基金Supported by the fund for Key Projects in the Army Medical and Health 9~(th) 5-year Plan (No. 96Z047), and the Fund for Chongqing Applied Base Research
文摘AIM： To investigate the effect of Helicobacter pylori （H pylon） infection on Bax protein expression, and explore the role of Hpyloriin gastric carcinogenesis. METHODS： Hpyloriwas assessed by rapid urease test and Warthin-Starry method, and expression of Bax protein was examined immunohistochemically in 72 patients with pre-malignant lesions. RESULTS： Bax protein was differently expressed in intestinal metaplasia and gastric dysplasia, and showed 63.99% positivity. The positivity of Bax protein expression in Hpylori-positive gastric precancerous lesions （72.3%） was significantly higher than that in H pylori-negative gastric precancerous lesions （48.0%, x^2= 4.191, P〈0.05）. Hpyloriinfection was well correlated with the expression of Bax protein in gastric precancerous lesions （r= 0.978, P〈0.01）. After eradication of H pylori, the positivity of Bax protein expression significantly decreased in Hpylori-positive gastric precancerous lesions （x^2 = 5.506, P〈0.05）. In the persisting H pylori-infected patients, the positivity of Bax protein expression was not changed. CONCLUSION： H pyloriinfection may be involved in the upregulation of Bax gene, which might be one of the mechanisms of Hpyloriinfection-induced gastric epithelial cell apoptosis. Hpylorimight act as a tumor promoter in the genesis of gastric carcinoma and eradication of Hpylori could inhibit gastric carcinogenesis.
基金Universiti Sains Malaysia under Fundamental Research Grant Scheme(FRGS)(Project:A/C No.6071002)Research University Grant(RU)(Project:A/C No.814004)+1 种基金Skim Penyelidikan Siswazah Universiti Penyelidikan(USM-RU-PRGS)(Project:A/C No.8042015)USM Fellowship
文摘A grating eddy current displacement sensor(GECDS) can be used in a watertight electronic transducer to realize long range displacement or position measurement with high accuracy in difficult industry conditions.The parameters optimization of the sensor is essential for economic and efficient production.This paper proposes a method to combine an artificial neural network(ANN) and a genetic algorithm(GA) for the sensor parameters optimization.A neural network model is developed to map the complex relationship between design parameters and the nonlinearity error of the GECDS,and then a GA is used in the optimization process to determine the design parameter values,resulting in a desired minimal nonlinearity error of about 0.11%.The calculated nonlinearity error is 0.25%.These results show that the proposed method performs well for the parameters optimization of the GECDS.
文摘The grating eddy current displacement sensor (GECDS) for distance or position measurement used in watertight electronic calipers was described. The sensor relies on repetitive variation of inductance against displacement caused by the change of coupling areas between moving coils and static reflectors. The investigations focused on setting up and utilizing a computer model of the 3D eddy current fields and geometry to analyze causes of the production of measurement blind areas, and to investigate effects of the sensor parameters, such as axial gap between coils and reflectors, reflector length and reflector width on characteristics of the sensor. Simulation results indicated that the sensor has the smallest nonlinearity error of 0.15%, which agrees well with the experimental results.
