Providing free treatment for severe mental disorders in China

Following the SARS outbreak in 2003 the Chinese government substantially strengthened its public health infrastructure.One of the new programs was the‘Central Government Support for the Local Management and Treatment of Severe Mental Illnesses Project’.Initially funded in December 2004 with 6.86 million Renminbi(829,000 in 2004 US$),the ongoing project has subsequently been referred to as the‘686 Project’.The aims of the project include establishing an effective system to control and prevent violent behaviors by individuals with severe mental disorder,increasing careseeking by persons with severe mental illnesses

Detection of Pesticide Metsulfuron-methyl in Drinking Water by Differential Pulse Cathodic Stripping Voltammetry

Differential pulse cathodic stripping voltammetry was used to determine pesticide metsulfuron-methyl on a suspended mercury electrode.Specific experimental parameters,such as the pH of Britton-Robinson buffer,accumulation time,accumulation potential,and initial potential were optimized.The results show that a typical reduction peak appeared when pH was 2.0-4.0 and initial potential ranged from-0.75 to-1.0 V.To obtain the stripping signal of the best reduction peak,it is determined that the best pH was 2.0.The detection limit of the method was only 0.04 mg/L,and it had good selectivity and high accuracy,so the method has high sensitivity.In the analysis of actual drinking water,the recovery rate of metsulfuron-methyl could reach 93%-101%.

Screening and identifying natural products with SARS-CoV-2 infection inhibitory activity from medicinal fungi

The coronavirus disease of 2019(COVID‐19),a global pandemic caused by the severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2),can result in severe health complications.In addition to physical preventative measures,pharmaceutical intervention is also crucial.Numerous natural products from medicinal fungi have shown promise as potential antiviral drugs and may serve as a source of effective components with antiviral activity against SARS‐CoV‐2 and other coronaviruses.In this study,we developed a workflow that integrates viral infection inhibition assays at both cellular and molecular levels,as well as molecular separation and characterization,to screen and identify natural products with antiviral activity.Using this workflow,we screened 167 extracts extracted from 36 medicinal fungi using optimized extraction methods.We assessed the antiviral effects of these extracts by measuring their ability to inhibit SARS‐CoV‐2 infection and receptor binding domain‐human angiotensin‐converting enzyme 2(RBD‐hACE2)binding in vitro.Following charge‐and size‐based characterization of the active compounds through filtration and chromatographic fractionation,mass spectrometry characterization of the fractionated compounds revealed that the active components are polysaccharides and determined their monosaccharide residue composition.Our findings provide new insights into the antiviral potential of natural products and their screening strategies and may contribute to the development of effective antiviral therapeutics against COVID‐19 and other diseases.

Unraveling the nature of cerium on stabilizing Cu/SAPO-34 NH_(3)-SCR catalysts under hydrothermal aging at low temperatures

To reveal how cerium stabilizes Cu/SAPO-34 at low-temperature hydrothermal aging,various amounts of cerium were introduced into Cu/SAPO-34 via impregnation method and treated at 70℃with RH 80%for 96 h.Cerium as Ce^(3+)and CeO_(2)nanoparticle is located on the surface of Cu/SAPO-34,and Ce^(3+)plays a vital role on gradually decreasing surface acidity and blocking defect sites with an increase of Ce loading.After hydrothermal aging,Cu/SAPO-34 with high Ce loading shows the superior SCR activity comparable to fresh samples.It is proven that the surface acidity determines the stability of the structure during hydrothermal aging process,and lower surface acidity prevents the number of Cu(Ⅱ)ions from decreasing significantly.Furthermore,the structure's stability helps the recovery of Cu(Ⅱ)ions and renders an outstanding regene ration ability.Our finding paves the way for the design of new Cu/SAPO-34catalysts with good SCR activity and long-term stability in real application.

A homogeneous dopamine-silver nanocomposite coating:striking a balance between the antibacterial ability and cytocompatibility of dental implants

Silver has been widely used for surface modification to prevent implant-associated infections.However,the inherent cytotoxicity of silver greatly limited the scope of its clinical applications.The construction of surfaces with both good antibacterial properties and favorable cytocompatibility still remains a challenge.In this study,a structurally homogeneous dopamine-silver(DA/Ag)nanocomposite was fabricated on the implant surface to balance the antibacterial activity and cytocompatibility of the implant.The results show that the DA/Ag nanocomposites prepared under the acidic conditions(pH=4)on the titanium surface are homogeneous with higher Ag^(+)content,while an obvious core(AgNPs)-shell(PDA)structure is formed under neutral(pH=7)and alkaline conditions(pH=10),and the subsequent heat treatment enhanced the stability of PDA-AgNPs nanocomposite coatings on porous titanium.The antibacterial test,cytotoxicity test,hypodermic implantation and osteogenesis test revealed that the homogeneous PDA-AgNPs nanocomposite coating achieved the balance between the antibacterial ability and cytocompatibility,and had the best outcomes for soft tissue healing and bone formation around the implants.This study provides a facile strategy for preparing silver-loaded surfaces with both good antibacterial effect and favorable cytocompatibility,which is expected to further improve the therapeutic efficacy of silver composite-coated dental implants.

Gut microbiota from end-stage renal disease patients disrupt gut barrier function by excessive production of phenol

End stage renal disease (ESRD), an advanced stage of chronic kidney disease, has received increasing attention as a leading public health problem (Webster et al., 2017). Chronic kidney disease (CKD) and ESRD are invariably accompanied by chronic systemic inflammation which plays central roles in CKD progression (Cachofeiro et al., 2008) and the increased mortality due to cardiovascular disease (Landray et al., 2004).

Oxygen-vacancy-rich phenanthroline/TiO_(2) nanocomposites: An integrated adsorption, detection and photocatalytic material for complex pollutants remediation

To address the challenge of treating complex pollutants containing heavy metals and organic compounds,a phenanthroline/TiO_(2)nanocomposite with rich oxygen vacancy defects was synthesized to integrate the functions of pollutant detection, adsorption, and photocatalytic degradation. The results showed that the nanocomposite could adsorb Cr^(3+)and the process could be transduced into a colorimetric signal for qualitative and quantitative detection. The adsorbed heavy metal also exhibited a synergistically enhanced photocatalytic degradation of a model organic pollutant under visible light. The simultaneous adsorption, detection, and photocatalysis could reduce the multifarious operations and high cost of traditional environmental remediation methods, indicating a strong application potential for the nanocomposite.

Stability of selenium and its speciation analysis in water using automatic system separation and HR-ICP-MS measurement

A simple and convenient method has been developed for the pre-concentration and separation of inorganic selenium species from environmental water samples using anion exchange chromatographic column combined with high resolution inductively coupled plasma mass spectrometry(HR-ICP-MS)measurement.^(75)Se(Ⅳ) and ^(75)Se(Ⅵ)were prepared and used as tracers during the experiments.The volatility of selenium during solution evaporation was investigated to establish a reliable water samples pretreatment procedure.The parameters which affect the uptake of Se(Ⅳ)and Se(Ⅵ)on Dowex1×8 resin was optimized and the procedure for Se(Ⅳ)and Se(Ⅵ)separation was proposed.Both Se(Ⅳ)and Se(Ⅵ)are retained on the column in natural or alkaline solution with high distribution coefficient.The successive gradient elution of pre-concentrated species of selenium with HNO_(3)solution allows to differentiate between them.Se(Ⅳ)and Se(Ⅵ)finally were eluted with 0.05 mol/L HNO_(3) and 5.0 mol/L HNO_(3),respectively.The proposed method has been successfully verified using the certified reference materials(CRMs)of real water samples,and spiked recoveries for real samples were 98%-104%with 5%relative standard deviations(RSDs).The developed procedure is proved to be reliable and can be used for the rapid determination of selenium species in environmental water samples.