Clinical Value of rhBNP in the Treatment of Patients with Stanford Type B Aortic Dissection

Objective:To determine the clinical value of rhBNP in the treatment of patients with Stanford type B aortic dissection.Methods:From June 2018 to October 2021,162 patients with Stanford type B aortic dissection were selected from the Cardiology Department of Henan Provincial Chest Hospital and randomly divided into two groups:control group(81 patients)and observation group(81 patients).The patients in the control group were treated with conventional therapy.On the basis of the control group,the patients in the observation group were treated with rhBNP.The cardiac function,renal function,pulmonary function,and inflammatory indices before and after treatment for 72 hours,as well as the incidence of adverse reactions between the two groups were compared.Results:After treatment,the cardiac function(LVEF and NT-pro BNP),renal function(urine output for 24 hours,SCr,and Cys-C),pulmonary function(PaO_(2),SPO_(2),and PaO_(2)/FiO_(2)),and inflammatory(IL-6,hsCRP,and MCP-1)indices of the observation group improved significantly compared to those of the control group(p<0.05).Conclusion:rhBNP can improve cardiac function,renal function,and pulmonary function,as well as alleviate inflammation in patients with Stanford type B aortic dissection.Hence,in the treatment of patients with Stanford type B aortic dissection,rhBNP provides multi-organ protection.

Assembling ionic liquid into porous molecular filler of mixed matrix membrane to trigger high gas permeability,selectivity,and stability for CO_(2)/CH_(4) separation

As an emerging zero-dimensional nano crystalline porous material,porous organic cages(POCs)with soluble properties in organic solvents,are promising candidates as molecular fillers in mixed matrix membranes(MMMs).The pore structure of POCs should be adjusted to trigger efficient gas separation performance,and the interaction between filler and matrix should be optimized.In this work,ionic liquid(IL)was introduced into the molecular fillers of CC3,to construct the IL@CC3/PIM-1 membrane to effectively separate CO_(2) from CH_(4).The advantages of doping IL include:(1)narrowing the cavity size of POCs from 4.4 to 3.9Åto enhance the diffusion selectivity,(2)strengthening the CO_(2) solubility to heighten the gas permeability,and(3)improving the compatibility between filler and matrix to upgrade membrane stability.After the optimization of the membrane composite,the IL@CC3/PIM-1-10%membrane possesses the CO_(2) permeability of 7868 Barrer and the CO_(2)/CH_(4) selectivity of 73.4,which compared to the CC3/PIM-1-10%membrane,improved by 15.9%and 106.2%,respectively.Furthermore,the membrane has maintained a stable separation performance at varied temperatures and pressures during the long-term test.The proposed method offers an efficient way to improve the performance of POCs-based MMMs in gas separation.

Fe-Based Metal-Organic Frameworks:From Various Synthesis,Diverse Structures to Multifunctional Applications

Iron-based metal-organic frameworks(Fe-MOFs)have attracted extensive interest from researchers due to their tunability,favorable properties,and chemical versatility.Compared with conventional porous materials,Fe-MOFs exhibit better performance in a wide variety of applications.Herein,the structures of Fe-MOFs are summarized to explore potential structures based on isoreticular chemistry,as well as the recent research progress in their synthesis and multifunctional applications.The rapid development of Fe-MOFs has broadened the application range of Fe-MOFs,and a brief description of Fe-MOF applications in gas storage and separation,catalysis,bioimaging,and magnetism is outlined,with the aim to expand the prospects of Fe-MOFs in more practical applications.

Metal-ion-tuned metal-organic frameworks for C_(2)H_(2)/CO_(2) separation

Adsorptive separation of acetylene(C_(2)H_(2))from carbon dioxide(CO_(2))by adsorption is a viable method for producing high-purity C_(2)H_(2) required for industrial applications.However,separating C_(2)H_(2) and CO_(2) is challenging due to their extremely similar molecular sizes and physical properties.Metal-Organic Frameworks(MOFs),as a novel porous material with high specific surface area and tunable pore size,have shown great potential in the separation and purification of light hydrocarbons.Herein,we synthesized three isoreticular Al-MOFs(Al-TCPP,Al-TCPP(Co),and Al-TCPP(Fe))by modulating metal ions at the porphyrin center,all of which can effectively separate C_(2)H_(2)/CO_(2).The addition of metal ions can regulate and improve the separation selectivity of C_(2)H_(2)/CO_(2).Compared with the parent Al-TCPP,the IAST selectivities of Al-TCPP(Co)and Al-TCPP(Fe)for equimolar C_(2)H_(2)/CO_(2) increased from 1.73 to 3.66 and 4.43,respectively.Breakthrough experiments validate their efficient separation of C_(2)H_(2)/CO_(2).Furthermore,they all exhibit excellent hydrothermal stability,laying the foundation for practical applications.

Pore-Environment Engineering in Multifunctional Metal-Organic Frameworks

Contents 1.Introduction 5102.Direct Synthesis 5102.1.Functional modification of ligands 5102.2.Functional modification of secondary buildingunits(SBU)5112.3.Multivariate metal-organic frameworks(MTV-MOF)5123.Post-Synthesis Modification(PSM)5123.1.Post-synthetic metal exchange(PSME)5133.2.Post-synthetic ligand exchange(PSLE)5133.3.Post-synthetic elimination and insertion(PSE&I)5144.Building Block Replacement(BBR)5144.1.Solvent-assisted linker exchange(SALE)5144.2.Non-bridged ligand replacement 5154.3.Transmetalation at nodes or within linkers 5165.Pore Space Partition in MOF(PSP)5175.1.Cage-within-Cage MOFs 5175.2.One-dimensional channel segmentation 5186.Construction of Multi-mesoporous MOF 5186.1.Linker thermolysis 5186.2.Chemical shear 5197.Dynamic Septal Ligand Insertion 5198.Conclusions and Perspectives 5201.Introduction Metal-Organic Frameworks(MOFs)are organic-inorganic hy-brid crystalline materials with intramolecular pores formed byself-assembly of organic ligands and inorganic metal ions or clus-ters through coordination bonds.[1]Compared with traditionalinorganic porous materials,MOFs have flexible ligands and metalnodes,large specific surface area,adjustable pore size,and modi-fiable structure,which show great potential in gas storage,sepa-ration,catalysis and energy technology applications.[2]At thesame time,the clear and adjustable crystal structure provides anideal platform for the study of material structure-activity(struc-ture-performance)relationship,which makes MOFs have greatadvantages in structural research and practical applications.

Ligand controlled structure of cadmium(Ⅱ) metal-organic frameworks for fluorescence sensing of Fe^(3+) ion and nitroaromatic compounds

Three cadmium(II) metal-organic frameworks(MOFs) based on tetracarboxylate ligands, namely[Cd_2(TTTA)(DMF)_3]·2 DMF(1),[Cd_2(TB)(H_2O)_4]·3DMF·H_2O(2)and [Cd(TEB)_(0.5)].2 DMF.4 H_2O(3) have been designed and synthesized. Complex 1 is a 2-dimensional(2 D) 3,4-connected network with 3,4 L13 topology, complex 2 features a 3-dimensional(3D) 3,4-connected tfa topology with a 2-fold interpenetrating structure and complex 3 has a 3D 4-connected dia topology with a 4-fold interpenetrating structure. Interestingly, 2 exhibits permanent pores and selective adsorption of CO_2 over CH_4. In addition, 2 shows fluorescence sensing of Fe^(3+) ion and rapid detection of nitroaromatic compounds(NACs) through fluorescence quenching.

Two-dimensional cobalt metal-organic frameworks for efficient C_3H_6/CH_4 and C_3H_8/CH_4 hydrocarbon separation

A Co-based two-dimensional（2 D） microporous metal-organic frameworks, [Co2（TMTA）（DMF）2（H2O）2]·NO3-·DMF（UPC-32） has been synthesized based on 4,4’,4’’-（2,4,6-trimethylbenzene-1,3,5-triyl）tribenzoic acid（H3TMTA）. UPC-32 features a 2 D microporous framework exhibits high adsorption of H2（118.2 cm3/g, 1.05 wt%, at 77 K）, and adsorption heat（Qst） of CO2（34–46 k J/mol）. UPC-32 with narrow distance between layers（3.8 ？） exhibits high selectivity of C3H6/CH4（31.46） and C3H8/CH4（28.04） at298 K and 1 bar. It is the first 2 D Co-MOF that showed selective separation of C3 hydrocarbon from CH4.

Two alkynyl functionalized Co（Ⅱ）-MOFs as fluorescent sensors exhibiting selectivity and sensitivity for Fe3+ and nitroaromatic compounds

Two Co(II)-MOFs with different structures were successfully synthesized under the premise of designing two ligands containing alkynyl functional groups. Complexes 1 ([Co(TEPA)(TPT)2/3]·2DMF·H2O) and 2 ([Co(EPA)(TPT)]·1.5DMF·1.5H2O) show excellent luminescence properties. Meanwhile, as fluorescent sensors, complexes 1 and 2 exhibit selectivity and sensitivity for Fe3+ with the Ksv of 1.520 ×104 L/mol and 3.543 ×104 L/mol, which can rapidly detect nitroaromatic compounds in methanol and ethanol, especially for 2,4-NPH through fluorescence quenching with high quenching efficiency. In particular, the Ksv value of complexes 1 and 2 towards 2,4-NPH can reach up to 1.627 ×105 L/mol and 9.600 ×104 L/mol, demonstrating that complexes 1 and 2 are good candidates for the identification and detection of Fe3+and nitroaromatic compounds.