Disorders of gastrointestinal(GI)motility are associated with various symptoms such as nausea,vomiting,and constipation.However,the underlying causes of impaired GI motility remainunclear,which has led to variation in...Disorders of gastrointestinal(GI)motility are associated with various symptoms such as nausea,vomiting,and constipation.However,the underlying causes of impaired GI motility remainunclear,which has led to variation in the efficacy of therapies to treat GI dysfunction.Optoge-netics is a novel approach through which target cells can be precisely controlled by light and hasshown great potential in GI motility research.Here,we summarized recent studies of GI motilitypatterns utilizing optogenetic devices and focused on the ability of opsins,which are geneticallyexpressed in different types of cells in the gut,to regulate the excitability of target cells.We hopethat our review of recent findings regarding optogenetic control of GI cells broadens the scope ofapplication for optogenetics in GI motility studies.展开更多
文摘Disorders of gastrointestinal(GI)motility are associated with various symptoms such as nausea,vomiting,and constipation.However,the underlying causes of impaired GI motility remainunclear,which has led to variation in the efficacy of therapies to treat GI dysfunction.Optoge-netics is a novel approach through which target cells can be precisely controlled by light and hasshown great potential in GI motility research.Here,we summarized recent studies of GI motilitypatterns utilizing optogenetic devices and focused on the ability of opsins,which are geneticallyexpressed in different types of cells in the gut,to regulate the excitability of target cells.We hopethat our review of recent findings regarding optogenetic control of GI cells broadens the scope ofapplication for optogenetics in GI motility studies.
基金supported by a grant from Fundamental Research Funds for the Central Universities[Grant No.16ykjc25 addressed to L.K.]the Sun Yat-sen University Clinical Research 5010 Program[Grant No.2016005 addressed to L.K.].
