A series of 1,2,4-triazole derivatives were synthesized, and their abilities to inhibit the in vitro replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole derivatives, compound 3 g displayed potent a...A series of 1,2,4-triazole derivatives were synthesized, and their abilities to inhibit the in vitro replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole derivatives, compound 3 g displayed potent activity, with a high antiviral potency (IC50 = 1.71 μM (against CVB3), 1.43 μM (against CVB6)). The structures of all the new synthesized compounds were confirmed by 1H-NMR spectra, mass spectra and elemental analyses.展开更多
Dear Editor,The expression profile demonstrates how each gene was expressed in the target tissue or cell at a given time.Cell heterogeneity is a biological concept characterized by the presence of numerous cells with ...Dear Editor,The expression profile demonstrates how each gene was expressed in the target tissue or cell at a given time.Cell heterogeneity is a biological concept characterized by the presence of numerous cells with varying functions and expression profiles within organ/tissue samples.There is also cell-to-cell signaling,which implies that the extracellular environment and spatial location influence intracellular transcription,resulting in spatial heterogeneity of gene expression within the same cell type.展开更多
Introduction Omicron is more contagious and stealthier than the previous strains.The basic reproduction number of Omicron is around 8–12,whereas that of the previous mainstream strain Delta is only 5–8[1].Omicron’s...Introduction Omicron is more contagious and stealthier than the previous strains.The basic reproduction number of Omicron is around 8–12,whereas that of the previous mainstream strain Delta is only 5–8[1].Omicron’s symptoms are relatively mild[2]compared with Delta’s symptoms;however,Omicron’s transmission ability is very strong,and its risk to children and the elderly remains high[3].In addition,the vaccine’s preventive effect on Omicron has weakened.Therefore,Omicron can easily cause a rapid outbreak in a city.The population density of megacities and the limited public health resources further exacerbate the difficulty of Omicron prevention and control.展开更多
Dear Editor,Using sc RNA-seq technology, researchers may distinguish between different cell types and tissue heterogeneity as well as perform transcriptome investigations at the single-cell level (Regev et al., 2017)....Dear Editor,Using sc RNA-seq technology, researchers may distinguish between different cell types and tissue heterogeneity as well as perform transcriptome investigations at the single-cell level (Regev et al., 2017). A significant amount of single-cell transcriptome data has been produced as a result of the technology’s quick development and widespread adoption.Research on other model species has also gathered a sizable quantity of transcriptome data at the single-cell level.展开更多
文摘A series of 1,2,4-triazole derivatives were synthesized, and their abilities to inhibit the in vitro replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole derivatives, compound 3 g displayed potent activity, with a high antiviral potency (IC50 = 1.71 μM (against CVB3), 1.43 μM (against CVB6)). The structures of all the new synthesized compounds were confirmed by 1H-NMR spectra, mass spectra and elemental analyses.
基金supported by the National Key Research and Development Program of China(2021YFD1200804,2018YFD0901201)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA24010206)。
文摘Dear Editor,The expression profile demonstrates how each gene was expressed in the target tissue or cell at a given time.Cell heterogeneity is a biological concept characterized by the presence of numerous cells with varying functions and expression profiles within organ/tissue samples.There is also cell-to-cell signaling,which implies that the extracellular environment and spatial location influence intracellular transcription,resulting in spatial heterogeneity of gene expression within the same cell type.
文摘Introduction Omicron is more contagious and stealthier than the previous strains.The basic reproduction number of Omicron is around 8–12,whereas that of the previous mainstream strain Delta is only 5–8[1].Omicron’s symptoms are relatively mild[2]compared with Delta’s symptoms;however,Omicron’s transmission ability is very strong,and its risk to children and the elderly remains high[3].In addition,the vaccine’s preventive effect on Omicron has weakened.Therefore,Omicron can easily cause a rapid outbreak in a city.The population density of megacities and the limited public health resources further exacerbate the difficulty of Omicron prevention and control.
基金supported by the National Key Research and Development Program of China (2021YFD1200804 and2018YFD0901201)the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA24010206)supported by the Wuhan Branch,Supercomputing Center,Chinese Academy of Sciences,China。
文摘Dear Editor,Using sc RNA-seq technology, researchers may distinguish between different cell types and tissue heterogeneity as well as perform transcriptome investigations at the single-cell level (Regev et al., 2017). A significant amount of single-cell transcriptome data has been produced as a result of the technology’s quick development and widespread adoption.Research on other model species has also gathered a sizable quantity of transcriptome data at the single-cell level.
