This paper proposes the concept of inter-cell relay for downlink orthogonal frequency division multiple access(OFDMA) cellular systems, which uses multi-hop to relay calls from overloaded cells to light-load neighbori...This paper proposes the concept of inter-cell relay for downlink orthogonal frequency division multiple access(OFDMA) cellular systems, which uses multi-hop to relay calls from overloaded cells to light-load neighboring cells. It is shown that when using inter-cell relay, the number of calls in the congestion cell can be significantly increased. The congestion cell is divided into two parts. One is called non-relay area(NRA), in which a call directly communicates with the base station(BS) of a congested cell. The other is called relay area(RA), in which a call communicates with the BS of a neighboring cell through a relay station(RS). The two parts have different user-call densities. By adjusting the densities of two parts, we will maximize the number of supported calls inside a congested cell. The results show the benefits gained from inter-cell relay in congestion relief, which can reduce cell congestion by fully utilizing the available resources in the neighboring cells.展开更多
Background:Thoracic aortic aneurysm(TAA)is a fatal cardiovascular disease,the pathogenesis of which has not yet been clarified.This study aimed to identify and validate the diagnostic markers of TAA to provide a stron...Background:Thoracic aortic aneurysm(TAA)is a fatal cardiovascular disease,the pathogenesis of which has not yet been clarified.This study aimed to identify and validate the diagnostic markers of TAA to provide a strong theoretical basis for developing new methods to prevent and treat this disease.Methods:Gene expression profiles of the GSE9106,GSE26155,and GSE155468 datasets were acquired from the Gene Expression Omnibus(GEO)database.Differentially expressed genes(DEGs)were identified using the"limma"package in R.Least absolute shrinkage and selection operator(LASSO),support vector machine-recursive feature elimination(SVM-RFE),random forest,and binary logistic regression analyses were used to screen the diagnostic marker genes.Single-sample gene set enrichment analysis(ssGSEA)was used to estimate immune cell infiltration in TAA.Results:A total of 16 DEGs were identified.The enrichment and functional correlation analyses showed that DEGs were mainly associated with inflammatory response pathways and collagen-related diseases.Collagen type I alpha 1 chain(COL1A1)and synaptotagmin like 2(SYTL2)were identified as diagnostic marker genes with a high diagnostic value for TAA.The expression of COL1A1 and SYTL2 was considerably higher in TAA vascular wall tissues than in the corresponding normal tissues,and there were significant differences in the infiltration of immune cells between TAA and normal vascular wall tissues.Additionally,COL1A1 and SYTL2 expression were associated with the infiltration of immune cells in the vascular wall tissue.Single-cell analysis showed that COL1A1 in TAA was mainly derived from fibroblasts and SYTL2 mainly from cluster of differentiation(CD)8+T cells.In addition,single-cell analysis indicated that fibroblasts and CD8+T cells in TAA were significantly higher than those in normal arterial wall tissue.Conclusions:COL1A1 and SYTL2 may serve as diagnostic marker genes for TAA.The upregulation of SYTL2 and COL1A1 may be involved in the inflammatory infiltration of the vessel wall and poor extracellular matrix remodeling,promoting the progression of TAA.展开更多
基金National Natural Science Foundation of China under grant number (61872186,61872193)The National Natural Science Foundation of China for Youth (61201160, 61602263)+8 种基金The Natural Science Foundation of Jiangsu Province (BK20131377, BK20151507, BK20160916)The Natural science fund for colleges and universities in Jiangsu Province under Grants (16KJB510034)The six talent peaks project in Jiangsu Province (XYDXXJS-044)A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (yx002001)The Jiangsu Overseas Research and Training Program for University Prominent Young and Middle-aged Teachers and PresidentsSponsored by NUPTSF (Grant Nos. NY212012, NY214065,NY216020)The Six Talented Eminence Foundation of Jiangsu Province (No. XYDXXJS-044)The 333 High-level Talents Training Project of Jiangsu ProvinceThe 1311 Talents Plan of NUPT and the China Postdoctoral Science Foundation (No. 2018M630590)
文摘This paper proposes the concept of inter-cell relay for downlink orthogonal frequency division multiple access(OFDMA) cellular systems, which uses multi-hop to relay calls from overloaded cells to light-load neighboring cells. It is shown that when using inter-cell relay, the number of calls in the congestion cell can be significantly increased. The congestion cell is divided into two parts. One is called non-relay area(NRA), in which a call directly communicates with the base station(BS) of a congested cell. The other is called relay area(RA), in which a call communicates with the BS of a neighboring cell through a relay station(RS). The two parts have different user-call densities. By adjusting the densities of two parts, we will maximize the number of supported calls inside a congested cell. The results show the benefits gained from inter-cell relay in congestion relief, which can reduce cell congestion by fully utilizing the available resources in the neighboring cells.
基金supported by grants from the National Natural Science Foundation of China(No.81970412)Xiamen Municipal Health Science and Technology Program Fund(No.3502Z20194034)+1 种基金Natural Science Foundation of Fujian Province(No.2022J011414)Xiamen Medical and Health Guidance Project(No.3502220214201088)
文摘Background:Thoracic aortic aneurysm(TAA)is a fatal cardiovascular disease,the pathogenesis of which has not yet been clarified.This study aimed to identify and validate the diagnostic markers of TAA to provide a strong theoretical basis for developing new methods to prevent and treat this disease.Methods:Gene expression profiles of the GSE9106,GSE26155,and GSE155468 datasets were acquired from the Gene Expression Omnibus(GEO)database.Differentially expressed genes(DEGs)were identified using the"limma"package in R.Least absolute shrinkage and selection operator(LASSO),support vector machine-recursive feature elimination(SVM-RFE),random forest,and binary logistic regression analyses were used to screen the diagnostic marker genes.Single-sample gene set enrichment analysis(ssGSEA)was used to estimate immune cell infiltration in TAA.Results:A total of 16 DEGs were identified.The enrichment and functional correlation analyses showed that DEGs were mainly associated with inflammatory response pathways and collagen-related diseases.Collagen type I alpha 1 chain(COL1A1)and synaptotagmin like 2(SYTL2)were identified as diagnostic marker genes with a high diagnostic value for TAA.The expression of COL1A1 and SYTL2 was considerably higher in TAA vascular wall tissues than in the corresponding normal tissues,and there were significant differences in the infiltration of immune cells between TAA and normal vascular wall tissues.Additionally,COL1A1 and SYTL2 expression were associated with the infiltration of immune cells in the vascular wall tissue.Single-cell analysis showed that COL1A1 in TAA was mainly derived from fibroblasts and SYTL2 mainly from cluster of differentiation(CD)8+T cells.In addition,single-cell analysis indicated that fibroblasts and CD8+T cells in TAA were significantly higher than those in normal arterial wall tissue.Conclusions:COL1A1 and SYTL2 may serve as diagnostic marker genes for TAA.The upregulation of SYTL2 and COL1A1 may be involved in the inflammatory infiltration of the vessel wall and poor extracellular matrix remodeling,promoting the progression of TAA.