In order to solve information island problem of offshore oil and gas field production-related information system,including repetitive reporting and input of data,data isolation of central control system,inadequate fol...In order to solve information island problem of offshore oil and gas field production-related information system,including repetitive reporting and input of data,data isolation of central control system,inadequate follow-up analysis and development to support oil and gas field production management,and so on.Therefore,the introduction of MES(Manufacturing Execution System)production execution system in the manufacturing industry and downstream production of offshore oil has become an inevitable choice.This system utilizes the real-time database combined with relational database to collect the scattered structured data,such as the production process real-time data,production management documents and statistical tables of offshore oil and gas production facilities.It establishes a unified data center platform for each operation area and production site,so as to centralize the related production management data at production sites.This system realizes many functions,including the production management support like production report generation as well as presentation and POB,equipment management support like PM optimization,remote configuration and monitoring of production operation,status trend analysis,and production event prediction.The implementation of MES system in offshore oil and gas field production management perfects the overall information system of China National Offshore Oil Corporation more and gradually enhances its comprehensive benefits.展开更多
The TMPRSS2‐ERG fusion gene has frequently been found in prostate cancer and is associated with malignancy.Identifying novel fusions will help to stratify patients and establish patient‐tailored therapies.A 78‐year...The TMPRSS2‐ERG fusion gene has frequently been found in prostate cancer and is associated with malignancy.Identifying novel fusions will help to stratify patients and establish patient‐tailored therapies.A 78‐year‐old man presented to our hospital with severe symptoms of urinary urgency and frequency for 2 years,as well as severe bone pain for 1 year.He was diagnosed with metastatic prostate cancer with a Gleason score of 5+5.Three gene fusions,ERG_VEGFA,TMPRSS2_ERG,and VEGFA_TMPRSS2,were identified in the patient's prostate cancer tissue.Notably,administration of the tyrosine kinase inhibitor,anlotinib,in combination with a gonadotropinreleasing hormone agonist(GnRHa)and abiraterone,reduced the patient's bone pain and also stabilized his prostate cancer for more than 2 years.This is the first report of somatic fusions among the VEGFA,ERG,and TMPRSS2 genes in cancer tissues from a patient with prostate cancer who responded well to antiangiogenic treatment combined with a GnRHa and abiraterone.展开更多
文摘In order to solve information island problem of offshore oil and gas field production-related information system,including repetitive reporting and input of data,data isolation of central control system,inadequate follow-up analysis and development to support oil and gas field production management,and so on.Therefore,the introduction of MES(Manufacturing Execution System)production execution system in the manufacturing industry and downstream production of offshore oil has become an inevitable choice.This system utilizes the real-time database combined with relational database to collect the scattered structured data,such as the production process real-time data,production management documents and statistical tables of offshore oil and gas production facilities.It establishes a unified data center platform for each operation area and production site,so as to centralize the related production management data at production sites.This system realizes many functions,including the production management support like production report generation as well as presentation and POB,equipment management support like PM optimization,remote configuration and monitoring of production operation,status trend analysis,and production event prediction.The implementation of MES system in offshore oil and gas field production management perfects the overall information system of China National Offshore Oil Corporation more and gradually enhances its comprehensive benefits.
基金University Research Project of Army Medical University,Grant/Award Numbers:2017XYY07,2018XLC1014,2019CXLCB006。
文摘The TMPRSS2‐ERG fusion gene has frequently been found in prostate cancer and is associated with malignancy.Identifying novel fusions will help to stratify patients and establish patient‐tailored therapies.A 78‐year‐old man presented to our hospital with severe symptoms of urinary urgency and frequency for 2 years,as well as severe bone pain for 1 year.He was diagnosed with metastatic prostate cancer with a Gleason score of 5+5.Three gene fusions,ERG_VEGFA,TMPRSS2_ERG,and VEGFA_TMPRSS2,were identified in the patient's prostate cancer tissue.Notably,administration of the tyrosine kinase inhibitor,anlotinib,in combination with a gonadotropinreleasing hormone agonist(GnRHa)and abiraterone,reduced the patient's bone pain and also stabilized his prostate cancer for more than 2 years.This is the first report of somatic fusions among the VEGFA,ERG,and TMPRSS2 genes in cancer tissues from a patient with prostate cancer who responded well to antiangiogenic treatment combined with a GnRHa and abiraterone.
