HCSP-Net:A Novel Model of Age-RelatedMacular Degeneration Classification Based on Color Fundus Photography

Age-related macular degeneration(AMD)ranks third among the most common causes of blindness.As the most conventional and direct method for identifying AMD,color fundus photography has become prominent owing to its consistency,ease of use,and good quality in extensive clinical practice.In this study,a convolutional neural network(CSPDarknet53)was combined with a transformer to construct a new hybrid model,HCSP-Net.This hybrid model was employed to tri-classify color fundus photography into the normal macula(NM),dry macular degeneration(DMD),and wet macular degeneration(WMD)based on clinical classification manifestations,thus identifying and resolving AMD as early as possible with color fundus photography.To further enhance the performance of this model,grouped convolution was introduced in this study without significantly increasing the number of parameters.HCSP-Net was validated using an independent test set.The average precision of HCSPNet in the diagnosis of AMD was 99.2%,the recall rate was 98.2%,the F1-Score was 98.7%,the PPV(positive predictive value)was 99.2%,and the NPV(negative predictive value)was 99.6%.Moreover,a knowledge distillation approach was also adopted to develop a lightweight student network(SCSP-Net).The experimental results revealed a noteworthy enhancement in the accuracy of SCSP-Net,rising from 94%to 97%,while remarkably reducing the parameter count to a quarter of HCSP-Net.This attribute positions SCSP-Net as a highly suitable candidate for the deployment of resource-constrained devices,which may provide ophthalmologists with an efficient tool for diagnosing AMD.

校园环境质量监测实践课程的实施与体会

校园环境质量监测实践课程是一门实践性很强的综合性实践课程。课程目标既有知识与技能目标,又有过程与方法目标,还有情感、态度和价值观目标。为了较好地达成课程目标,既要制定合理的实施方案,又要执行严格的实施过程。指导教师要做好集体备课、课前动员、分组指导、成绩评定和课后总结的每一个环节。

Experimental analysis of pore structure and fractal characteristics of soft and hard coals with same coalifcation

Accurate and quantitative investigation of the physical structure and fractal geometry of coal has important theoretical and practical signifcance for coal bed methane(CBM)development and the prevention of dynamic disasters such as coal and gas outbursts.This study investigates the pore structure and fractal characteristics of soft and hard coals using nitrogen and carbon dioxide(N_(2)/CO_(2))adsorption.Coal samples from Pingdingshan Mine in Henan province of China were collected and pulverized to the required size(0.20–0.25 mm).N_(2)/CO_(2)adsorption tests were performed to evaluate the specifc surface area(SSA),pore size distribution(PSD),and pore volume(PV)using Braunuer-Emmett-Teller(BET),Barrett-Joyner-Halenda(BJH),and Density Functional Theory(DFT).The pore structure was characterized based on the theory of fractal dimensions.The results unveiled that the strength of coal has a signifcant infuence on pore structure and fractal dimensions.There are signifcant diferences in SSA and PV between both coals.The BJH-PV and BET-SSA obtained by N_(2)-adsorption for soft coal are 0.029–0.032 cm^(3)/g and 3.523–4.783 m^(2)/g.While the values of PV and SSA obtained by CO_(2)-adsorption are 0.037–0.039 cm^(3)/g and 106.016–111.870 m^(2)/g.Soft coal shows greater SSA and PV than hard coal,which is consistent with the adsorption capacity(VL).The fractal dimensions of soft and hard coal are respectively diferent.The Ding coal exhibits larger D1 and smaller D_(2),and the reverse for the Wu coal seam is observed.The greater the value of D1(complexity of pore surface)of soft coal is,the larger the pore surface roughness and gas adsorption capacity is.The results enable us to conclude that the characterization of pores and fractal dimensions of soft and hard coals is diferent,tending to diferent adsorption/desorption characteristics.In this regard,the results provide a reference for formulating corresponding coal and gas outburst prevention and control measures.

加强税收协调 营造粤港澳大湾区良好营商税收环境

建设粤港澳大湾区是国家战略,实现湾区发展目标需要良好的营商税收环境。根据粤港澳大湾区自身特点,做好税收协调是营造湾区良好营商税收环境的关键。本文论述了营造粤港澳大湾区良好营商税收环境的必要性,并提出加强法制建设、建立税收协调制度,健全税收协调机构、定期组织联席会议,解决税制实施和税收征管矛盾、消除市场壁垒,建立粤港澳大湾区协调平台、连通三地征管系统的建议,以促进湾区健康发展。

亮氨酸脱氢酶偶联NADH再生体系合成L-2-氨基丁酸

文中以大肠杆菌BL21(DE3)为宿主,构建两株分别共表达亮氨酸脱氢酶(LDH,来源蜡样芽孢杆菌)/甲酸脱氢酶(FDH,来源水生弯杆菌)和亮氨酸脱氢酶(LDH,来源蜡样芽孢杆菌)/醇脱氢酶(ADH,来源红球菌)的重组大肠杆菌。通过偶联两种不同NADH再生体系,以L-苏氨酸为起始原料,利用苏氨酸脱氨酶(L-TD)与LDH-FDH或LDH-ADH一锅法合成L-2-氨基丁酸,并对LDH-FDH工艺和LDH-ADH工艺进行对比优化。LDH-FDH工艺的最适反应pH为7.5,最适反应温度为35℃,通过加入50 g/L甲酸铵、0.3 g/L NAD^+、10%LDH-FDH粗酶液(V/V)和7500 U/L的L-TD酶液,对L-苏氨酸进行分批补加,以便控制2-丁酮酸浓度小于15 g/L,反应28 h,实现了L-2-氨基丁酸的产量为161.8 g/L,产率97%。LDH-ADH工艺的最适pH为8.0,最适反应温度为35℃,通过加入0.3 g/L NAD^+、10%LDH-ADH粗酶液(V/V)及7500 U/L的L-TD酶液,分批补加L-苏氨酸及1.2倍摩尔量异丙醇,以便控制2-丁酮酸浓度小于15 g/L,且每生成约40 g/L的L-2-氨基丁酸,抽真空去除丙酮,反应24 h,实现了L-2-氨基丁酸的产量为119.6 g/L,产率98%。文中所采用的工艺及结果可为L-2-氨基丁酸的工业化提供一定的参考依据。

Heat transfer characteristics in a narrow confined channel with discrete impingement cooling

Heat transfer characteristics in a narrow confined channel with discrete impingement cooling were investigated using thermal infrared camera. Detailed heat transfer distributions and comparisons on three surfaces with three impact diameters were experimentally studied in the range of Reynolds number of 3000 to 30000. The experimental results indicated that the strong impingement jet leaded to a high strength heat transfer zone in the ΔX=±2.5D;range of the impact center,which was 1.3–2.5 times of the average heat transfer value of the impingement wall. With the same coolant mass flow rate, small diameter case had lower heat transfer coefficient on both inner wall and outside wall, while the impingement wall was insensitive to the impact diameter. The surface averaged Nusselt number of inner wall was only 43%–57% of impingement wall, while the outside wall can reach up to 80%–90%. The larger the diameter, the higher heat transfer enhancement and the smaller the channel flow resistance was observed in term of Reynolds number. The surface averaged Nusselt numbers were developed as the function of Reynolds number and the impingement height-to-diameter for further engineering applications.

Annotation and quality control specifications for fundus color photograph

1.Scope This article sets terms and definitions,basic requirements,annotat-ing requirements,and quality control for fundus color photograph an-notating.This article applies to the fundus color photograph of annotating and quality control of four ocular diseases signs for the purpose of referral or screening,including glaucoma,macular disorders,high myopic macular degeneration and diabetic retinopathy.Note:When referring to this article,please pay attention to the scope of annotating the signs of macular disorders in this document.

The national multi-center artificial intelligent myopia prevention and control project

In recent years,the incidence of myopia has increased at an alarming rate among children and adolescents in China.The exploration of an effective prevention and control method for myopia is in urgent need.With the development of information technology in the past decade,artificial intelligence with the Internet of Things technology(AIoT)is characterized by strong computing power,advanced algorithm,continuous monitoring,and accurate prediction of long-term progression.Therefore,big data and artificial intelligence technology have the potential to be applied to data mining of myopia etiology and prediction of myopia occurrence and development.More recently,there has been a growing recognition that myopia study involving AIoT needs to undergo a rigorous evaluation to demonstrate robust results.

Role of social organization engagement in high-risk groups intervention against HIV/AIDS:a case study from 176 cities of China

Background: A high-risk prevention strategy is an effective way to fight against human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). The China AIDS Fund for Non-Governmental Organizations (CAFNGO) was established in 2015 to help social organizations intervene to protect high-risk populations in 176 cities. This study aimed to evaluate the role of social organizations in high-risk population interventions against HIV/AIDS.Methods: This study was based on the CAFNGO program from 2016 to 2020. The collected data included the number and types of social organizations participating in high-risk group interventions and the amount of funds obtained by these organizations each year. We explored the factors influencing the number of newly diagnosed AIDS cases using a spatial econometric model. Furthermore, we evaluated the effectiveness of intervention activities by comparing the percentages of the individuals who initially tested positive, and the individuals who took the confirmatory test, as well as those who retested positive and underwent the treatment.Results: Overall, from 2016 to 2020, the number of social organizations involved in interventions to protect HIV/AIDS high-risk populations increased from 441 to 532, and the invested fund increased from $3.98 to $10.58 million. The number of newly diagnosed cases decreased from 9128 to 8546 during the same period. Although the number of cities with overall spatial correlations decreased, the spatial agglomeration effect persisted in the large cities. Citywise, the number of social organizations (direct effect 19.13), the permanent resident population (direct effect 0.12), GDP per capita (direct effect 17.58;indirect effect -15.38), and passenger turnover volume (direct effect 5.50;indirect effect -8.64) were the major factors influencing new positive cases confirmed through the testing interventions performed by the social organizations. The initial positive test rates among high-risk populations were below 5.5%, the retesting rates among those who initially tested positive were above 60%, and the treatment rates among diagnosed cases were above 70%.Conclusions: The spatial effect of social organizations participating in interventions targeting high-risk populations funded by CAFNGO is statistically significant. Nevertheless, despite the achievements of these social organizations in tracking new cases and encouraging treatment, a series of measures should be taken to further optimize the use of CAFNGO. Working data should be updated from social organizations to CAFNGO more frequently by establishing a data monitoring system to help better track newly diagnosed AIDS cases. Multichannel financing should be expanded as well.

A survey on book-embedding of planar graphs

The book-embedding problem arises in several area,such as very large scale integration(VLSI)design and routing multilayer printed circuit boards(PCBs).It can be used into various practical application fields.A book embedding of a graph G is an embedding of its vertices along the spine of a book,and an embedding of its edges to the pages such that edges embedded on the same page do not intersect.The minimum number of pages in which a graph G can be embedded is called the pagenumber or book-thickness of the graph G.It is an important measure of the quality for book-embedding.It is NP-hard to research the pagenumber of book-embedding for a graph G.This paper summarizes the studies on the book-embedding of planar graphs in recent years.