Arranging dense donors around a single acceptor for the assembly of effi-cient light-harvesting antennas is a long-standing challenge due to the intractable aggregation-caused quenching of dense donors.Herein,we desig...Arranging dense donors around a single acceptor for the assembly of effi-cient light-harvesting antennas is a long-standing challenge due to the intractable aggregation-caused quenching of dense donors.Herein,we designed a cationic aggregation-induced emission(AIE)amphiphile to self-assemble with natural DNA duplexes.As an efficient donor,the as-prepared cationic AIE amphiphile could be densely attached to the phosphate groups of natural DNA duplexes by using the smaller cationic trimethylammonium.The long alkyl chain between the cationic trimethylammonium and the AIEfluorophore allowed for avoiding the insuffi-cient binding caused by the steric hindrance of the AIEfluorophore,resulting in a remarkably high donor/acceptor ratio comparable to that of the widely developed custom DNA assemblies.The proposed self-assembly strategy provided novelflex-ible avenues for the assembling offinely controlled and efficient light-harvesting systems into natural DNA with little synthetic modifications and low cost.展开更多
Cationic amphiphile aggregates exhibit superior antibacterial activity than monomers.However,the antimicrobial mechanism of aggregates has not been well understood because it is difficult to distinguish and monitor ag...Cationic amphiphile aggregates exhibit superior antibacterial activity than monomers.However,the antimicrobial mechanism of aggregates has not been well understood because it is difficult to distinguish and monitor aggregate and monomer in antimicrobial process.Herein,three bola-type cationic amphiphiles with aggregation-induced emission property have been developed to show distinguishable fluorescence in their monomer and aggregate.The hydrophilicity of monomer and the stability of aggregate are finely tuned by tailoring the linkers between two quaternary ammonium end groups and tetraphenylethylene skeleton.The sensitive fluorescence switching of monomer and aggregate achieves the quantitative monitoring of dynamic interaction of three amphiphiles with bacteria.The aggregates with cationic charges first attach to bacterial surface,and the monomers subsequently dissociate from aggregates to penetrate bacterial membrane.Further,our results reveal the vital role of stability of aggregates during antimicrobial process,shedding light on the rational design of high-efficient antimicrobials.展开更多
基金National Natural Science Foundation of China,Grant/Award Numbers:U22A20397,21974008Beijing Natural Science Foundation,Grant/Award Number:2212013Fundamental Research Funds for the Central Universities,Grant/Award Number:buctrc201820。
文摘Arranging dense donors around a single acceptor for the assembly of effi-cient light-harvesting antennas is a long-standing challenge due to the intractable aggregation-caused quenching of dense donors.Herein,we designed a cationic aggregation-induced emission(AIE)amphiphile to self-assemble with natural DNA duplexes.As an efficient donor,the as-prepared cationic AIE amphiphile could be densely attached to the phosphate groups of natural DNA duplexes by using the smaller cationic trimethylammonium.The long alkyl chain between the cationic trimethylammonium and the AIEfluorophore allowed for avoiding the insuffi-cient binding caused by the steric hindrance of the AIEfluorophore,resulting in a remarkably high donor/acceptor ratio comparable to that of the widely developed custom DNA assemblies.The proposed self-assembly strategy provided novelflex-ible avenues for the assembling offinely controlled and efficient light-harvesting systems into natural DNA with little synthetic modifications and low cost.
基金National Natural Science Foundation of China,Grant/Award Number:22002137Natural Science Foundation of Jiangsu Province,Grant/Award Number:BK20200920+1 种基金Beijing Natural Science Foundation,Grant/Award Number:2212013Shenzhen Key Laboratory of Functional Aggregate Materials,Grant/Award Number:ZDSYS20211021111400001。
文摘Cationic amphiphile aggregates exhibit superior antibacterial activity than monomers.However,the antimicrobial mechanism of aggregates has not been well understood because it is difficult to distinguish and monitor aggregate and monomer in antimicrobial process.Herein,three bola-type cationic amphiphiles with aggregation-induced emission property have been developed to show distinguishable fluorescence in their monomer and aggregate.The hydrophilicity of monomer and the stability of aggregate are finely tuned by tailoring the linkers between two quaternary ammonium end groups and tetraphenylethylene skeleton.The sensitive fluorescence switching of monomer and aggregate achieves the quantitative monitoring of dynamic interaction of three amphiphiles with bacteria.The aggregates with cationic charges first attach to bacterial surface,and the monomers subsequently dissociate from aggregates to penetrate bacterial membrane.Further,our results reveal the vital role of stability of aggregates during antimicrobial process,shedding light on the rational design of high-efficient antimicrobials.
