Atherosclerosis is a severe cardiovascular disease followed by the accumulation of atherosclerotic plaques within the lumen of blood vessels resulting in reduced blood flow thus initiating a series of events.Conventio...Atherosclerosis is a severe cardiovascular disease followed by the accumulation of atherosclerotic plaques within the lumen of blood vessels resulting in reduced blood flow thus initiating a series of events.Conventional therapies for atherosclerosis encounter multiple chal-lenges,especially difficulty in precisely concentrating in certain affected regions and the potential for unwanted side effects.Consequently,scientists are focused on developing nanoformulations for atherosclerosis diagnosis and therapy.Peptide-based nanomedi-cines improve conventional therapies by offering improved structural and therapeutic stability and enabling target-specific delivery.Their inherent biocompatibility and biodegradability additionally render them desirable materials intended for in vivo use.This review manu-script aims to provide an in-depth overview of peptide-based nano-medicines for atherosclerosis,focusing on targeted cells like endothelial cells,macrophages,and monocytes and their interaction with different plaque components.Moreover,the manuscript also highlights the latest progress in multimodal techniques and provides a comprehensive overview of limitations associated with their practical implementation.展开更多
文摘Atherosclerosis is a severe cardiovascular disease followed by the accumulation of atherosclerotic plaques within the lumen of blood vessels resulting in reduced blood flow thus initiating a series of events.Conventional therapies for atherosclerosis encounter multiple chal-lenges,especially difficulty in precisely concentrating in certain affected regions and the potential for unwanted side effects.Consequently,scientists are focused on developing nanoformulations for atherosclerosis diagnosis and therapy.Peptide-based nanomedi-cines improve conventional therapies by offering improved structural and therapeutic stability and enabling target-specific delivery.Their inherent biocompatibility and biodegradability additionally render them desirable materials intended for in vivo use.This review manu-script aims to provide an in-depth overview of peptide-based nano-medicines for atherosclerosis,focusing on targeted cells like endothelial cells,macrophages,and monocytes and their interaction with different plaque components.Moreover,the manuscript also highlights the latest progress in multimodal techniques and provides a comprehensive overview of limitations associated with their practical implementation.
