Background and Aims:The aim was to evaluate the efficacy and safety of Yanggan Jian(YGJ)in HBV-infected patients with decompensated cirrhosis.Methods:This randomized,double-blind controlled trial enrolled 160 patients...Background and Aims:The aim was to evaluate the efficacy and safety of Yanggan Jian(YGJ)in HBV-infected patients with decompensated cirrhosis.Methods:This randomized,double-blind controlled trial enrolled 160 patients with HBV-related decompensated cirrhosis who were already receiving or about to start antiviral therapy.Patients were randomly assigned to receive YGJ or placebo for 24 weeks,and were followed-up to 36 weeks.The primary outcome was the proportion of patients with a≥2 point reduction in Child-Turcotte-Pugh(CTP)score from baseline at week 24.Secondary outcomes were CTP class and score,serum liver function indices,mortality,incidence of hepatocellular carcinoma and variceal bleeding.Results:The proportion of patients with a CTP score reduction≥2 was significantly greater in the YGJ than in the placebo group(p=0.009);the percentage of patients with CTP class C was significantly less than that in the placebo group(p<0.05),and the YGJ group had a significantly greater mean change from baseline in CTP score at week 24(p=0.034).The improvement in measured values and change from baseline of prothrombin time,serum albumin,platelets,cholinesterase,international normalized ratio,and activated partial thromboplastin time were significantly better with YGJ than with placebo.Between-group differences in cumulative rates of variceal bleeding,hepatocellular carcinoma,death,or the frequency of any adverse event(AE),AEs related to treatment,or discontinuation because of AEs were not significant.Conclusions:YGJ significantly improved CTP scores and hepatic synthetic and reserve function in patients with HBV-related decompensated cirrhosis,and was safe and well tolerated.展开更多
We investigate the distribution of rational points on singular cubic surfaces,whose coordinates have few prime factors.The key tools used are universal torors,the circle method and results on linear equations in primes.
Let f be a holomorphic Hecke cusp form with even integral weight k≥2 for the full modular group,and letχbe a primitive Dirichlet character modulo q.Let Lf(s,χ)be the automorphic L-function attached to f andχ-We st...Let f be a holomorphic Hecke cusp form with even integral weight k≥2 for the full modular group,and letχbe a primitive Dirichlet character modulo q.Let Lf(s,χ)be the automorphic L-function attached to f andχ-We study the mean-square estimate of Lf(s,χ)and establish an asymptotic formula.展开更多
基金supported by the National Natural Science Foundation of China (82130120)Shanghai Science and Technology Committee Rising-Star Program (19QA1408900)+1 种基金WBE Liver Fibrosis Foundation (CFHPC2020010)Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine (SGXZ-201908 and SGKJLC-202013).
文摘Background and Aims:The aim was to evaluate the efficacy and safety of Yanggan Jian(YGJ)in HBV-infected patients with decompensated cirrhosis.Methods:This randomized,double-blind controlled trial enrolled 160 patients with HBV-related decompensated cirrhosis who were already receiving or about to start antiviral therapy.Patients were randomly assigned to receive YGJ or placebo for 24 weeks,and were followed-up to 36 weeks.The primary outcome was the proportion of patients with a≥2 point reduction in Child-Turcotte-Pugh(CTP)score from baseline at week 24.Secondary outcomes were CTP class and score,serum liver function indices,mortality,incidence of hepatocellular carcinoma and variceal bleeding.Results:The proportion of patients with a CTP score reduction≥2 was significantly greater in the YGJ than in the placebo group(p=0.009);the percentage of patients with CTP class C was significantly less than that in the placebo group(p<0.05),and the YGJ group had a significantly greater mean change from baseline in CTP score at week 24(p=0.034).The improvement in measured values and change from baseline of prothrombin time,serum albumin,platelets,cholinesterase,international normalized ratio,and activated partial thromboplastin time were significantly better with YGJ than with placebo.Between-group differences in cumulative rates of variceal bleeding,hepatocellular carcinoma,death,or the frequency of any adverse event(AE),AEs related to treatment,or discontinuation because of AEs were not significant.Conclusions:YGJ significantly improved CTP scores and hepatic synthetic and reserve function in patients with HBV-related decompensated cirrhosis,and was safe and well tolerated.
文摘We investigate the distribution of rational points on singular cubic surfaces,whose coordinates have few prime factors.The key tools used are universal torors,the circle method and results on linear equations in primes.
基金the National Natural Science Foundation of China(Grant No.11601309).
文摘Let f be a holomorphic Hecke cusp form with even integral weight k≥2 for the full modular group,and letχbe a primitive Dirichlet character modulo q.Let Lf(s,χ)be the automorphic L-function attached to f andχ-We study the mean-square estimate of Lf(s,χ)and establish an asymptotic formula.
