目的:分析广东省中山市小榄镇肝癌高危人群筛查依从性和队列人群后续肝癌患者发病情况。方法:筛查方案参照《中国癌症筛查及早诊早治技术方案(2011年版)进行》,2012年开始对中山市小榄镇进行肝癌筛查,对ELISA法检测发现的乙肝表面抗原(h...目的:分析广东省中山市小榄镇肝癌高危人群筛查依从性和队列人群后续肝癌患者发病情况。方法:筛查方案参照《中国癌症筛查及早诊早治技术方案(2011年版)进行》,2012年开始对中山市小榄镇进行肝癌筛查,对ELISA法检测发现的乙肝表面抗原(hepatitis B virus surface antigen,HBsAg)阳性者,采用甲胎蛋白(alpha-fetorprotein,AFP)联合超声检查的方法开展每年两次的诊断性筛查。对肝癌高危人群进行随访,随访截至2017年12月31日。统计学分析肺癌的发病率及人群筛选依从性。结果:初筛队列19386人,检出HBsAg阳性者2882人,阳性率14.9%。剔除初筛时发现的13例肝癌,实际随访高危人群2869人。2014~2017年对肝癌高危人群连续4年进行随访,AFP检测依从性(58.9%)显著高于B超检查(57.2%)依从性(P<0.01)。AFP检测和B超检查上半年依从性分别为62.8%和62.2%,下半年依从性分别为55.0%和52.1%,上半年依从性均显著高于下半年(P<0.01)。整体女性筛查依从性高于男性;35~54岁男性随访依从性最低。筛查队列中HBsAg阳性人群肝癌发病率为363.5/105,显著高于HBsAg阴性人群肝癌发病率20.9/105(P<0.05),而两组人群肝癌早诊率差异无统计学意义(57.9%vs.47.4%,P>0.05)。B超高依从组和HBsAg阳性组中肝癌患者生存率分别高于低依从组和HBsAg阴性组(P<0.05)。结论:筛查队列依从性和高危人群肝癌早诊率低。队列中B超检查依从性高的肝癌生存率相对较好。提高HBsAg阳性人群筛查依从性,是提高肝癌早诊率及生存率的重要途径之一。展开更多
To master theoretical calculation for dust removal efficiency of high pressure atomization in an underground coal mine, the corresponding atomization characteristics and dust removal efficiency were both comprehensive...To master theoretical calculation for dust removal efficiency of high pressure atomization in an underground coal mine, the corresponding atomization characteristics and dust removal efficiency were both comprehensively studied in theory by virtue of related theories of hydromechanics and aerosol.According to actual measurements of flow coefficients and atomization angles of X-type swirl nozzle,computational formula was derived for atomized particle sizes of such a nozzle in conjunction with relevant empirical equation. Moreover, a mathematical model for applying high pressure atomization to dust removal in underground coal mine was also established to deduce theoretical computation formula of fractional efficiency. Then, Matlab was adopted to portray the relation curve between fractional efficiency and influence factors. In addition, a theoretical formula was also set up for removal efficiency of respirable dust and total coal dust based on dust size and frequency distribution equations. In the end,impacts of dust characteristic parameters on various dust removal efficiencies were analyzed.展开更多
Coal remains one of the principal sources of energy for the world.During the extraction,transport,and processing of coal in underground and surface mining operations,sig-nificant amounts of airborne respirable dusts c...Coal remains one of the principal sources of energy for the world.During the extraction,transport,and processing of coal in underground and surface mining operations,sig-nificant amounts of airborne respirable dusts can be gen-erated and released to the working space.Chronic exposure to coal dusts puts the miners at risk for various lung dis-eases,including coal workers'pneumoconiosis,emphy-sema,silicosis,and chronic bronchitis.Apart from the miners'lung disease,the coal mine dusts also potentially increase the risk of mine explosion which has been rec-ognized as one of the most severe hazards in underground coal mine.展开更多
文摘目的:分析广东省中山市小榄镇肝癌高危人群筛查依从性和队列人群后续肝癌患者发病情况。方法:筛查方案参照《中国癌症筛查及早诊早治技术方案(2011年版)进行》,2012年开始对中山市小榄镇进行肝癌筛查,对ELISA法检测发现的乙肝表面抗原(hepatitis B virus surface antigen,HBsAg)阳性者,采用甲胎蛋白(alpha-fetorprotein,AFP)联合超声检查的方法开展每年两次的诊断性筛查。对肝癌高危人群进行随访,随访截至2017年12月31日。统计学分析肺癌的发病率及人群筛选依从性。结果:初筛队列19386人,检出HBsAg阳性者2882人,阳性率14.9%。剔除初筛时发现的13例肝癌,实际随访高危人群2869人。2014~2017年对肝癌高危人群连续4年进行随访,AFP检测依从性(58.9%)显著高于B超检查(57.2%)依从性(P<0.01)。AFP检测和B超检查上半年依从性分别为62.8%和62.2%,下半年依从性分别为55.0%和52.1%,上半年依从性均显著高于下半年(P<0.01)。整体女性筛查依从性高于男性;35~54岁男性随访依从性最低。筛查队列中HBsAg阳性人群肝癌发病率为363.5/105,显著高于HBsAg阴性人群肝癌发病率20.9/105(P<0.05),而两组人群肝癌早诊率差异无统计学意义(57.9%vs.47.4%,P>0.05)。B超高依从组和HBsAg阳性组中肝癌患者生存率分别高于低依从组和HBsAg阴性组(P<0.05)。结论:筛查队列依从性和高危人群肝癌早诊率低。队列中B超检查依从性高的肝癌生存率相对较好。提高HBsAg阳性人群筛查依从性,是提高肝癌早诊率及生存率的重要途径之一。
基金Financial provided by the National Natural Science Foundation of China (Nos. 51574123 and U1361118)the China Postdoctoral Science Foundation (No. 2015M 582118)
文摘To master theoretical calculation for dust removal efficiency of high pressure atomization in an underground coal mine, the corresponding atomization characteristics and dust removal efficiency were both comprehensively studied in theory by virtue of related theories of hydromechanics and aerosol.According to actual measurements of flow coefficients and atomization angles of X-type swirl nozzle,computational formula was derived for atomized particle sizes of such a nozzle in conjunction with relevant empirical equation. Moreover, a mathematical model for applying high pressure atomization to dust removal in underground coal mine was also established to deduce theoretical computation formula of fractional efficiency. Then, Matlab was adopted to portray the relation curve between fractional efficiency and influence factors. In addition, a theoretical formula was also set up for removal efficiency of respirable dust and total coal dust based on dust size and frequency distribution equations. In the end,impacts of dust characteristic parameters on various dust removal efficiencies were analyzed.
文摘Coal remains one of the principal sources of energy for the world.During the extraction,transport,and processing of coal in underground and surface mining operations,sig-nificant amounts of airborne respirable dusts can be gen-erated and released to the working space.Chronic exposure to coal dusts puts the miners at risk for various lung dis-eases,including coal workers'pneumoconiosis,emphy-sema,silicosis,and chronic bronchitis.Apart from the miners'lung disease,the coal mine dusts also potentially increase the risk of mine explosion which has been rec-ognized as one of the most severe hazards in underground coal mine.
