Autoimmune mechanisms are likely involved in the pathogenesis of idiopathic dilated cardiomyopathy (IDC) and components of MHC may serve as markers for the propensity to develop immune-mediated myocardial damage.This ...Autoimmune mechanisms are likely involved in the pathogenesis of idiopathic dilated cardiomyopathy (IDC) and components of MHC may serve as markers for the propensity to develop immune-mediated myocardial damage.This study was conducted to investigate the possible association between HLA-DQA1,-DQB1 alleles and IDC in Han population from northern China by using PCR-based sequence-specific primer (PCR-SSP) technique for HLA genotyping.Among 68 unrelated IDC patients,4 probands of IDC pedigrees and 100 healthy controls,we found that the alleles of HLA-DQA1*0501 and HLA-DQB1*0303 conferred susceptibility to IDC while HLA-DQA1*0201 and HLA-DQB1*0502,*0504 alleles were in negative association with IDC.The serine at position 57 (SER^(57)) in the exon of HLA-DQB1*0502 and *0504 was confirmed in our experiment as a marker for resistance to IDC.The results suggest that HLA-DQ polymorphism may be involved in the pathogenesis of IDC.Cellular & Molecular Immunology.2004;1 (4):311-314.展开更多
文摘Autoimmune mechanisms are likely involved in the pathogenesis of idiopathic dilated cardiomyopathy (IDC) and components of MHC may serve as markers for the propensity to develop immune-mediated myocardial damage.This study was conducted to investigate the possible association between HLA-DQA1,-DQB1 alleles and IDC in Han population from northern China by using PCR-based sequence-specific primer (PCR-SSP) technique for HLA genotyping.Among 68 unrelated IDC patients,4 probands of IDC pedigrees and 100 healthy controls,we found that the alleles of HLA-DQA1*0501 and HLA-DQB1*0303 conferred susceptibility to IDC while HLA-DQA1*0201 and HLA-DQB1*0502,*0504 alleles were in negative association with IDC.The serine at position 57 (SER^(57)) in the exon of HLA-DQB1*0502 and *0504 was confirmed in our experiment as a marker for resistance to IDC.The results suggest that HLA-DQ polymorphism may be involved in the pathogenesis of IDC.Cellular & Molecular Immunology.2004;1 (4):311-314.
