Visible-light induced direct C–H difluoromethylation of quinoxalinones with 2-((difluoromethyl)sulfonyl)benzo[d]thiazole has been developed for the first time.A broad range of quinoxalinones were well tolerated and r...Visible-light induced direct C–H difluoromethylation of quinoxalinones with 2-((difluoromethyl)sulfonyl)benzo[d]thiazole has been developed for the first time.A broad range of quinoxalinones were well tolerated and reacted with difluorosulfone smoothly to give the corresponding products in moderate to good yields.Notably,no external photocatalyst or oxidant was required,which provides a practical and green protocol to access difluoromethylated quinoxalinones.Finally,the control experiments demonstrated a radical mechanism,and the density functional theory(DFT)calculations indicated the radicals were generated through the formation of an electron donoracceptor(EDA)complex.展开更多
基金Financial support from the National Natural Science Foundation of China(Nos.22101267,U1904212,U2004191 and 21803059)is gratefully appreciated.
文摘Visible-light induced direct C–H difluoromethylation of quinoxalinones with 2-((difluoromethyl)sulfonyl)benzo[d]thiazole has been developed for the first time.A broad range of quinoxalinones were well tolerated and reacted with difluorosulfone smoothly to give the corresponding products in moderate to good yields.Notably,no external photocatalyst or oxidant was required,which provides a practical and green protocol to access difluoromethylated quinoxalinones.Finally,the control experiments demonstrated a radical mechanism,and the density functional theory(DFT)calculations indicated the radicals were generated through the formation of an electron donoracceptor(EDA)complex.
