Closed Solution for Initial Post-Buckling Behavior Analysis of a Composite Beam with Shear Deformation Effect

This paper is focused on the post-buckling behavior of the fixed laminated composite beams with effects of axial compression force and the shear deformation.The analytical solutions are established for the original control equations(that is not simplified)by applying the Maclaurin series expansion,Chebyshev polynomials,the harmonic balance method and the Newton’s method.The validity of the present method is verified via comparing the analytical approximate solutions with the numerical ones which are obtained by the shooting method.The present third analytical approximate solutions can give excellent agreement with the numerical solutions for a wide range of the deformation amplitudes.What’s more,the effect of shear deformation on the post-bucking configuration of the sandwich beam is also proposed.It can be found that the shear angle has a great influence on the post-buckling load of composite beams.Therefore,the model simplifying the shear formation term as small quantity is not accurate for the case of sandwich beam with soft core.

低速水流下不同截面形状质量块压电能量收集器的实验研究

论文设计了一种适用于低流速水流中的悬臂梁式压电能量收集器,利用明渠流弯道水槽对五种质量相同、截面形状不同质量块的压电能量收集器进行实验研究.通过改变水的流速,得到不同质量块能量收集器收集功率和频率随流速的变化规律并进行分析.结果表明:在实验流速范围内,各质量块均存在起振流速,当低于起振流速时,收集的均方根功率(Mean Effective Power,RMS Power)约为零,超过起振流速后,收集功率随流速增加而改变;形状相似的质量块,起振流速较为接近,四棱柱的起振流速最低,圆柱次之,三棱柱的最大;质量块截面形状不同,能量收集器性能不同,其中以三棱柱(70°)的输出性能最好,在流速为0.54 m/s时收集到的最大功率为2.02 mW,分别是圆柱、四棱柱(50)和三棱柱(60°)的1.06、2.58、1.36倍.论文研究的悬臂梁式压电能量收集器通过压电结构的力/电转换功能从水流中提取能量,可实现微电子器件的无线供能,为类似压电能量收集器的设计提供借鉴.

KIF2C:a novel link between Wnt/β-catenin and mTORCI signaling in the pathogenesis of hepatocellular carcinoma

Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and is the fourth-leading cause of cancer-related deaths worldwide.HCC is refractory to many standard cancer treatments and the prognosis is often poor,highlighting a pressing need to identify biomarkers of aggressiveness and potential targets for future treatments.Kinesin family member 2C(KIF2C)is reported to be highly expressed in several human tumors.Nevertheless,the molecular mechanisms underlying the role of KIF2C in tumor development and progression have not been investigated.In this study,we found that KIF2C expression was significantly upregulated in HCC,and that KIF2C up-regulation was associated with a poor prognosis.Utilizing both gain and loss of function assays,we showed that KIF2C promoted HCC cell proliferation,migration,invasion,and metastasis both in vitro and in vivo.Mechanistically,we identified TBC1D7 as a binding partner of KIF2C,and this interaction disrupts the formation of the TSC complex,resulting in the enhancement of mammalian target of rapamycin complexl(mTORCI)signal transduction.Additionally,we found that KIF2C is a direct target of the Wnt/β-catenin pathway,and acts as a key factor in mediating the crosstalk between Wnt/β-catenin and mTORCI signaling.Thus,the results of our study establish a link between Wnt/β-catenin and mTORCI signaling,which highlights the potential of KIF2C as a therapeutic target for the treatment of HCC.

Engineering of dendritic dopant-free hole transport molecules:enabling ultrahigh fill factor in perovskite solar cells with optimized dendron construction

Developing dopant-free hole-transporting materials(HTMs)for high-performance perovskite solar cells(PVSCs)has been a very active research topic in recent years since HTMs play a critical role in optimizing interfacial charge carrier kinetics and in turn determining device performance.Here,a novel dendritic engineering strategy is first utilized to design HTMs with a D-A type molecular framework,and diphenylamine and/or carbazole is selected as the building block for constructing dendrons.All HTMs show good thermal stability and excellent film morphology,and the key optoelectronic properties could be fine-tuned by varying the dendron structure.Among them,MPA-Cz-BTI and MCz-Cz-BTI exhibit an improved interfacial contact with the perovskite active layer,and non-radiative recombination loss and charge transport loss can be effectively suppressed.Consequently,high power conversion efficiencies(PCEs)of 20.8%and 21.35%are achieved for MPA-Cz-BTI and MCz-Cz-BTI based devices,respectively,accompanied by excellent long-term storage stability.More encouragingly,ultrahigh fill factors of 85.2%and 83.5%are recorded for both devices,which are among the highest values reported to date.This work demonstrates the great potential of dendritic materials as a new type of dopant-free HTMs for high-performance PVSCs with excellent FF.

淋巴细胞密度及分布与直肠癌新辅助治疗反应的关系

背景:研究认为,淋巴细胞密度与直肠癌预后相关;但新辅助治疗前淋巴细胞分布模式对预后的影响尚不清楚。本研究旨在评估淋巴细胞的分布及密度与直肠癌新辅助治疗反应的关系。方法:对前瞻性队列中接受新辅助治疗的134例直肠癌患者进行回顾性分析。对新辅助治疗前活检标本进行免疫组化染色(CD4和CD8)。评估瘤内腺体周围淋巴细胞(IPL)和肿瘤浸润淋巴细胞(TIL)的密度。采用logistic回归模型(包括临床病理特征、分子特征及治疗方案)评估不同淋巴细胞的密度与肿瘤退缩分级(TRG)的关系。结果:CD8^(+)TIL密度高的患者接受新辅助治疗后获得了更佳的TRG(OR=0.23,95%CI:0.07-0.76,P<0.001)。而CD8^(+)IPL(P=0.033)、CD4^(+)IPL(P=0.156)和CD4^(+)TIL(P=0.170)则与TRG无明显相关性。敏感性分析未发现CD8^(+)TIL与新辅助放疗(P_(相互作用)=0.831)或化疗(P_(交互作用)=0.879)对TRG的影响存在交互作用。结论:本研究结果显示,CD8^(+)TIL而不是CD8^(+)IPL,可独立影响直肠癌新辅助治疗反应,这种影响不受放疗或化疗方案的干扰。