Bilateral inferior petrosal sinus sampling for the treatment of Cushing's disease Data from 52 cases from one institute over an eight-year period

The present study analyzed data from 108 Cushing＇s disease patients, who underwent transsphenoidal surgery in one hospital between January 2003 and April 2010, to investigate the performance value of bilateral inferior petrosal sinus sampling （BIPSS）. Of the 108 patients 52 underwent BIPSS prior to surgery and 56 did not. Results showed that BIPSS accuracy for the diagnosis of Cushing＇s disease was 86.5% （45/52）, and accuracy for adenoma lateralization during surgery was 76.9% （40/52）. In addition, early remission rate was significantly greater compared to patients without BIPSS. Results demonstrated that BIPSS facilitated localization and diagnosis of Cushing＇s disease and helped to predict adenoma lateralization.

Study on chemical composition of Viscum coloratum and its HPLC fingerprint in different harvest periods

The purpose of this study was to evaluate the similarity of chemical profile of Viscum loloratum harvested in different months using high performance liquid chromatography(HPLC)fingerprint and multivariate statistical analysis,and to determine the optimal harvest time of Viscum coloratum.8 compounds were isolated from Viscum coloratum by a variety of isolation techniques,3 of which were isolated from the genus Viscum L.for the first time.The fingerprint of Viscum coloratum was established by HPLC,and 16 common peaks were obtained,4 of which were identified by comparison with the reference substances.Results showed that the Viscum coloratum harvested in 6 months could be roughly divided into three groups based on the chemical profiles,and the Viscum coloratum harvested in January had higher levels of the marked compounds.The HPLC fingerprint objectively reveals the characteristics of Viscum coloratum harvested in different months,which can be used to evaluate and control the quality of Viscum coloratum harvested in different months.

A New Method of Image Restoration Technology Based on WGAN

With the development of image restoration technology based on deep learning,more complex problems are being solved,especially in image semantic inpainting based on context.Nowadays,image semantic inpainting techniques are becoming more mature.However,due to the limitations of memory,the instability of training,and the lack of sample diversity,the results of image restoration are still encountering difficult problems,such as repairing the content of glitches which cannot be well integrated with the original image.Therefore,we propose an image inpainting network based on Wasserstein generative adversarial network(WGAN)distance.With the corresponding technology having been adjusted and improved,we attempted to use the Adam algorithm to replace the traditional stochastic gradient descent,and another algorithm to optimize the training used in recent years.We evaluated our algorithm on the ImageNet dataset.We obtained high-quality restoration results,indicating that our algorithm improves the clarity and consistency of the image.

Chronology, Geochemistry and Geological Significance of Haizi Bimodal Intrusive Bodies in Wuding District, Central Yunnan

The Haizi diabase-granite porphyry composite rock mass is located in the Wuding-Yanjing taphrogenic trough within the Paleoproterozoic Kangdian fault-uplift zone. According to field observations, the diabase is divided into two types: central facies and marginal facies;the granite porphyry directly contacts the central facies of diabase without transitional intermediate rock. In order to disclose its geological and petrological significances, this paper carried out the LA-ICP-MS zircon U-Pb dating and geochemical investigation on both masses of Haizi diabase and granite porphyry. The results showed that the207Pb/206Pb weighted average age of granite porphyry is 1764 ± 18 Ma and diabase 1765 ± 5.4 Ma. The geochemical investigations revealed that the Haizi diabase is a kind of high-potassium alkaline basalt and the granite porphyry a kind of low-potassium rhyolite, both enriched with high field intensity elements and depleted in large-ion lithophile elements;there is obvious component intermittence between the diabase and the granite porphyry, both being bimodal and showing characteristics of continental rift valley magmatite. The?in situ?Hf isotope of dating zircon showed that mantle materials participated in the formation and emplacement of Haizi granite porphyry and crust materials participated in the formation of diabase. This meant that crustal remelting and accretion of new crust occurred in this region in the 1.7 Ga period. It can be therefore inferred that the Haizi bimodal intrusive rock came into being due to the breakup of Kunyang rift valley and rapid ascent of mantle materials in the 1.7 Ga period, which echoed the global Columbia supercontinent breakup and was the first petrological record of that breakup found at the southwest margin of Yangtze platform.

Fault Ride-Through Study of Wind Turbines

The installation of wind energy has increased rapidly around the world. The grid codes about the wind energy require wind turbine (WT) has the ability of fault (or low voltage) ride-through (FRT). To study the FRT operation of the wind farms, three methods were discussed. First, the rotor short current of doubly-fed induction generator (DFIG) was limited by introducing a rotor side protection circuit. Second, the voltage of DC bus was limited by a DC energy absorb circuit. Third, STATCOM was used to increase the low level voltages of the wind farm. Simulation under MATLAB was studied and the corresponding results were given and discussed. The methods proposed in this paper can limit the rotor short current and the DC voltage of the DFIG WT to some degree, but the voltage support to the power system during the fault largely depend on the installation place of STATCOM.

An Analysis of the Impact of Economic-Ecological Balance Mechanism Based on Non-Linear Partial Differential Equations on Land Financial Teaching Methods

This paper clarifies the relationship between the flow paths of the corresponding ecological flows because of the ecological impact for land consolidation, using external energy methods to measure the external input of the project area or the output of ecological products. The application for nonlinear estimation of partial differential equations to land consolidation, the project ecological flow and system efficiency were quantitatively calculated. It shows that the conflict between fairness and efficiency is caused under conditions and levels of value and ecological compensation mechanism is built as a criterion for this ecological economics. Based on the years of use of the land improvement project, the time evolution of regional net ecological value, natural resource dependence, renewable resource dependence, ecological output ratio, ecological carrying capacity and ecological sustainability after the implementation of the project was assessed.

Effect of sterilization methods on the flavor of cold brew coffee

This research used ultra-fast E-nose,E-tongue and SCA analysis to explore the effects of different sterilization methods(pasteurization,back pressure sterilization,high temperature short-term sterilization,membrane filtration treatment and high pressure processing)on cold brew coffee.The results showed that non-heat sterilization can better maintain the sensory quality of coffee liquid.Back pressure sterilization could reduce the pH value of coffee liquid to 4.65,and decrease the aroma content significantly by 50.5%(p<0.05),while the sourness and bitterness of coffee samples increased,which lowered the sensory quality of coffee.Among the heat sterilization treatments,high temperature short-term sterilization had relatively little effect on the sensory quality of the coffee beverage,and decreased the bitterness of the coffee.Taking sensory quality,nutrients and cost into consideration,it is suggested that high temperature short time sterilization is a prefered method.Thus,the results of this research provided a theoretical basis for the selection of sterilization method for cold brew coffee.

Physicochemical difference of coffee beans with different species,production areas and roasting degrees

In recent decades,the demand for coffee has seen a continuous increase,and the aroma and flavor of coffee has been widely studied.The current research chose coffee beans of two species(Coffea arabica and C.canephora)from five production areas(Brazil,India,Indonesia,Uganda and Vietnam)with four different roasting degrees(medium light,medium,medium dark and dark),to investigate the difference on physicochemical properties.The results showed that Arabica coffee beans had higher concentrations of fat and organic acids,and total amount of volatile compounds,whereas Robusta beans had higher concentrations of protein.With the increase of roasting degree,the concentrations of protein,fat,organic acids,and the total amount of volatile compounds of coffee beans increased,while the concentrations of chlorogenic acid compounds decreased.The discriminant analysis indicated that the tested coffee beans could be clearly discriminated by species and roasting degrees,but not by production area.The results of this research conclude the physicochemical difference of Arabica and Robusta beans with different roasting degrees.The results can provide a theoretical basis for coffee bean selection for the relevant industries.

Perioperative treatment of liver transplantation

A case of liver transplantation in the department of general surgery of the third affiliated hospital of Inner Mongolia medical school was collected and analyzed on the basis of diagnosis,physical examination and treatment.Liver transplantation was very complicated,accompanied by various postoperative complications.So this paper aims to share experience of perioperative management of liver transplantation among physicians.

Successful treatment of severe burn patients with multiple organ dysfunction syndrome:A case report

Multiple organ dysfunction syndrome is the presence of altered organ function of two or more organ systems in acute ill patients with severe trauma,burn,shock and infection.In this case,the patient with burn area amounted to 95%and the third-degree burn was up to 90%.He underwent gastrointestinal tract,blood clotting,lung,brain,heart,liver dysfunction,and cardiac arrest for 30 minutes during the courses of treatment,and was discharged from the hospital after 108 days on the basis of comprehensive treatment and repeated skin grafting.

Multi-omics analyses of G6PD deficiency variants in Chinese population

Glucose-6-phosphate dehydrogenase(G6PD)deficiency is one of the most prevalent hereditary and X-linked enzyme disorders caused by the pathogenetic G6PD(NM_001042351.2)variants(Yang et al.,2016).The clinical manifestations of G6PD deficiency offer a wide spectrum of diverse disease phenotypes(Hecker et al.,2013).Investigations of prevalence and molecular epidemiology demonstrate that G6PD deficiency affects over 400 milion individuals worldwide and leads to thousands of deaths annually(Mortality and Causes of Death,2015).

Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease(CKD)risk,but limited research evaluated the association of reallocating excessive sleep to other behavior with CKD.We included 104538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal Study,with self-reported time of daily-life behavior.Using isotemporal substitution models,we found that substituting 1 h of sleeping with sitting,walking,or moderate-to-vigorous physical activity was associated with a lower CKD prevalence.Leisure-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working population.In stratified analysis,a lower CKD prevalence related to substitution toward physical activity was found in long sleepers.More pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes,and they benefited from other behavior substitutions toward a more active way.The U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys,in which the pernicious link with oversleep could be reversed by time reallocation to physical activity.The divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition.

Early-life famine exposure,adulthood obesity patterns,and risk of low-energy fracture

Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains unknown.This study included 5323 community-dwelling subjects aged⩾40 years from China.Early-life famine exposure was identified based on the participants’birth dates.General obesity was assessed using the body mass index(BMI),and abdominal obesity was evaluated with the waist-to-hip ratio(WHR).Low-energy fracture was defined as fracture occurring after the age of⩾40 typically caused by falls from standing height or lower.Compared to the nonexposed group,the group with fetal,childhood,and adolescence famine exposure was associated with an increased risk of fracture in women with odds ratios(ORs)and 95%confidence intervals(CIs)of 3.55(1.57–8.05),3.90(1.57–9.71),and 3.53(1.05–11.88),respectively,but not in men.Significant interactions were observed between fetal famine exposure and general obesity with fracture among women(P for interaction=0.0008).Furthermore,compared with the groups with normal BMI and WHR,the group of women who underwent fetal famine exposure and had both general and abdominal obesity had the highest risk of fracture(OR,95%CI:3.32,1.17–9.40).These results indicate that early-life famine exposure interacts with adulthood general obesity and significantly increases the risk of low-energy fracture later in life in women.

Association between hemoglobin glycation index and 5-year major adverse cardiovascular events:the REACTION cohort study

Background:The hemoglobin glycation index(HGI)was developed to quantify glucose metabolism and individual differences and proved to be a robust measure of individual glycosylated hemoglobin(HbA1c)bias.Here,we aimed to explore the relationship between different HGIs and the risk of 5-year major adverse cardiovascular events(MACEs)by performing a large multicenter cohort study in China.Methods:A total of 9791 subjects from the Risk Evaluation of Cancers in Chinese Diabetic Individuals:a Longitudinal Study(the REACTION study)were divided into five subgroups(Q1-Q5)with the HGI quantiles(≤5th,>5th and≤33.3th,>33.3th and≤66.7th,>66.7th and≤95th,and>95th percentile).A multivariate logistic regression model constructed by the restricted cubic spline method was used to evaluate the relationship between the HGI and the 5-year MACE risk.Subgroup analysis between the HGI and covariates were explored to detect differences among the five subgroups.Results:The total 5-year MACE rate in the nationwide cohort was 6.87%(673/9791).Restricted cubic spline analysis suggested a U-shaped correlation between the HGI values and MACE risk after adjustment for cardiovascular risk factors(x^(2)=29.5,P<0.001).After adjustment for potential confounders,subjects with HGIs≤-0.75 or>0.82 showed odds ratios(ORs)for MACE of 1.471(95%confidence interval[CI],1.027-2.069)and 2.222(95%CI,1.641-3.026)compared to subjects with HGIs of>-0.75 and≤-0.20.In the subgroup with non-coronary heart disease,the risk of MACE was significantly higher in subjects with HGIs≤-0.75(OR,1.540[1.039-2.234];P=0.027)and>0.82(OR,2.022[1.392-2.890];P<0.001)compared to those with HGIs of≤-0.75 or>0.82 after adjustment for potential confounders.Conclusions:We found a U-shaped correlation between the HGI values and the risk of 5-year MACE.Both low and high HGIs were associated with an increased risk of MACE.Therefore,the HGI may predict the 5-year MACE risk.

Small-molecule anti-COVID-19 drugs and a focus on China's homegrown mindeudesivir(WV116)

The coronavirus disease 2019(COVID-19)pandemic has stimulated tremendous efforts to develop therapeutic agents that target severe acute respiratory syndrome coronavirus 2 to control viral infection.So far,a few small-molecule antiviral drugs,including nirmatrelvir-ritonavir(Paxlovid),remdesivir,and molnupiravir have been marketed for the treatment of COVID-19.Nirmatrelvir-ritonavir has been recommended by the World Health Organization as an early treatment for outpatients with mild-to-moderate COVID-19.However,the existing treatment options have limitations,and effective treatment strategies that are cost-effective and convenient for tackling COVID-19 are still needed.To date,four domestically developed oral anti-COVID-19 drugs have been granted conditional market approval in China.These drugs include azvudine,simnotrelvir-ritonavir(Xiannuoxin),leritrelvir,and mindeudesivir(VV11).Preclinical and clinical studies have explored the efficacy and tolerability of mindeudesivir and supported its early use in mild-to-moderate COVID-19 cases at high risk for progression.In this review,we discuss the most recent findings regarding the pharmacological mechanism and therapeutic effects focusing on mindeudesivir and other small-molecule antiviral agents for COVID-19.These findings will expand our understanding and highlight the potential widespread application of China's homegrown anti-COVID-19 drugs.

Performance evaluation for sustainability of wind energy project using improved multi-criteria decision-making method

Wind power can be an efficient way to alleviate energy shortage and environmental pollution,and to realize sustainable development in terms of energy generation.The sustainability assessment of a wind project among its alternatives is a complex task that cannot be solely simplified to environmental or economic feasibility.It requires the consideration of its technological and social aspects as well as other circumstances.This paper proposes a new method for selecting the most sustainable wind projects.The method is based on multi-criteria decision-making techniques.The analytic hierarchy process and entropy weight method are combined to determine the weights of evaluation indexes,and an innovative index-weight optimization method based on the Lagrange conditional extremum algorithm.The fuzzy technique for order preference by similarity to the ideal solution is applied to rank wind project alternatives considering functionality and proportionality of the system.Moreover,the sensitive analysis is applied to verify the robustness of the proposed method.The applicability of the method is demonstrated on a case study from China,where three main wind projects are analytically compared and ranked.The results indicated that the sustainable level of calculated wind power can provide a reference point for the planning and operation of the wind project.The results show that the proposed method is of both theoretical significance and practical application in engineering.

Voltage Security Operation Region Calculation Based on Improved Particle Swarm Optimization and Recursive Least Square Hybrid Algorithm

Large-scale voltage collapse incidences, which result in power outages over large regions and extensive economic losses, are presently common occurrences worldwide. To avoid voltage collapse and operate more safely and reliably, it is necessary to analyze the voltage security operation region(VSOR) of power systems, which has become a topic of increasing interest lately. In this paper, a novel improved particle swarm optimization and recursive least square(IPSO-RLS) hybrid algorithm is proposed to determine the VSOR of a power system. Also, stability analysis on the proposed algorithm is carried out by analyzing the errors and convergence accuracy of the obtained results. Firstly, the voltage stability and VSOR-surface of a power system are analyzed in this paper. Secondly, the two algorithms,namely IPSO and RLS algorithms, are studied individually.Based on this understanding, a novel IPSO-RLS hybrid algorithm is proposed to optimize the active and reactive power,and the voltage allowed to identify the VSOR-surface accurately. Finally, the proposed algorithm is validated by using a simulation case study on three wind farm regions of actual Hami Power Grid of China in DIg SILENT/Power Factory software.The error and accuracy of the obtained simulation results are analyzed and compared with those of the particle swarm optimization(PSO), IPSO and IPSO-RLS hybrid algorithms.

Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohort study

The association between serum uric acid and the risk of incident diabetes in Chinese adults remains unknown.This study aimed to investigate this association in a community-dwelling population aged≥40 years in Shanghai,China.Oral glucose tole3rance test was conducted during baseline and follow-up visits.Relative risk regression was utilized to examine the associations between baseline gender-specific serum uric acid levels and incident diabetes risk.A total of 613(10.3%)incident diabetes cases were identified during the follow-up visit after 4.5 years.Fasting plasma glucose,postload glucose,and glycated hemoglobin A1c during the follow-up visit progressively increased across the sex-specific quartiles of serum uric acid(all Ps<0.05).The incidence rate of diabetes increased across the quartiles of serum uric acid(7.43%,8.77%,11.47%,and 13.43%).Multivariate adjusted regression analysis revealed that individuals in the highest quartile had 1.36-fold increased risk of diabetes compared with those in the lowest quartile of serum uric acid(odds ratio(95%confidence interval)=1.36(1.06−1.73)).Stratified analysis indicated that the association was only observed in women.Accordingly,serum uric acid was associated with the increased risk of incident diabetes among middle-aged and elderly Chinese women.

Shale pore characteristics of Shahejie Formation: Implication for pore evolution of shale oil reservoirs in Dongying sag, north China

The pore characteristics of shale reservoirs in the lower submember of Member 3 to upper submember of Member 4 of Shahejie Formation in Dongying sag are analyzed,influences of mineral content and organic matter content on porosity and pore size are also investigated,and through the diagenetic thermal simulation experiment,the main pore evolution is further discussed.The results show that the pore structure of shale reservoirs is complex,the micron-nanometer pores can storage liquid hydrocarbons,and the free-phase crude oil is mainly distributed in intergranular dissolution pores of calcite,recrystallized intergranular pores,intergranular shrinkage fractures of clay mineral which have large pore size.Framework minerals and organic matter content directly influence porosity and pore size of shale reservoirs,relationship between porosity and content of felsic mineral as well as content of organic matter content is linear and positive,while relationship between content of carbonated mineral is negative.At the buried depth from 2500 to 3500 m,concentration of organic acid from hydrocarbon generation and expulsion of organic matter,increasing range of pressure coefficient,are well corresponding to highporosity intervals;pore formation in shale oil reservoirs are almost controlled by diagenetic evolution of clay minerals;framework storage spaces formed by carbonate grain crystals as well as intergranular and intergranular dissolution pores of carbonate increases porosity of shale oil reservoirs;local increase of porosity at the depth of 3500e3800 m is mainly caused by coupling of hydrocarbon-generating overpressure and dissolution,and size,distribution and connectivity of pores are enhanced obviously.

Current situation of AIDS prevention and control with traditional Chinese medicine and relevant policies in China

This article analyzes the current system,the prevention and treatment team,drugs relating to AIDS prevention and control with traditional Chinese medicine,and the relevant policies in China so as to provide scientific advice on improving the policies and to promote the role of traditional Chinese medicine in treating AIDS.