Integrating surface enhanced Raman scattering (SERS) with microfluidics is the long-term goal for reduced volume,multiplex and automation fingerprint detection of biomolecules.High sensitivity,repeatability,stability,...Integrating surface enhanced Raman scattering (SERS) with microfluidics is the long-term goal for reduced volume,multiplex and automation fingerprint detection of biomolecules.High sensitivity,repeatability,stability,reusability and real-time detection are the performance goals of Raman detection in the aqueous solution environment.Here,we reported the study on cavity mode enhanced SERS detection of both surface-adsorbed molecules and non-surface-adsorbed molecules in the solution environment.The cavity modes had important influence on the SERS enhancement,especially for the non-surface adsorbed molecules.Uniform,repeatable,reusable and real-time Raman signal detection of the non-surface adsorbed Rhodamine 6G molecules was demonstrated.Our work is an important step for the practical on-chip microfluidic Raman detection applications.展开更多
基金supported by the Ministry of Science and Technology of China (No.2017YFA0205800)the National Natural Science Foundation of China (Nos.11404247 and 11674256).
文摘Integrating surface enhanced Raman scattering (SERS) with microfluidics is the long-term goal for reduced volume,multiplex and automation fingerprint detection of biomolecules.High sensitivity,repeatability,stability,reusability and real-time detection are the performance goals of Raman detection in the aqueous solution environment.Here,we reported the study on cavity mode enhanced SERS detection of both surface-adsorbed molecules and non-surface-adsorbed molecules in the solution environment.The cavity modes had important influence on the SERS enhancement,especially for the non-surface adsorbed molecules.Uniform,repeatable,reusable and real-time Raman signal detection of the non-surface adsorbed Rhodamine 6G molecules was demonstrated.Our work is an important step for the practical on-chip microfluidic Raman detection applications.
