Leveraging the unique features of light in biosafety,sensitivity,and resolution,optical technologies have seen a wide application in diagnosing and treating biological tissues,as well as in uncovering the mysteries an...Leveraging the unique features of light in biosafety,sensitivity,and resolution,optical technologies have seen a wide application in diagnosing and treating biological tissues,as well as in uncovering the mysteries and patterns of life.However,the application of light remains constrained in deep tissues,as researchers struggle to achieve the same or comparable high-resolution focusing and imaging as in superficial tissues.This limitation mainly arises from the spatial inhomogeneities of refractive index(RI)in biological tissues,where light propagation is severely hindered by scattering and absorption.展开更多
Optical techniques offer a wide variety of applications as light-matter interactions provide extremely sensitive mechanisms to probe or treat target media.Most of these implementations rely on the usage of ballistic o...Optical techniques offer a wide variety of applications as light-matter interactions provide extremely sensitive mechanisms to probe or treat target media.Most of these implementations rely on the usage of ballistic or quasi-ballistic photons to achieve high spatial resolution.However,the inherent scattering nature of light in biological tissues or tissue-like scattering media constitutes a critical obstacle that has restricted the penetration depth of non-scattered photons and hence limited the implementation of most optical techniques for wider applications.In addition,the components of an optical system are usually designed and manufactured for a fixed function or performance.Recent advances in wavefront shaping have demonstrated that scattering-or component-induced phase distortions can be compensated by optimizing the wavefront of the input light pattern through iteration or by conjugating the transmission matrix of the scattering medium.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.81930048)the Hong Kong Research Grant Council(Grant Nos.15217721,15125724,and C7074-21GF)+1 种基金the Guangdong Science and Technology Commission(Grant No.2019BT02X105),the Shenzhen Science and Technology Innovation Commission(Grant No.JCYJ20220818100202005)the Hong Kong Polytechnic University(Grant Nos.P0038180,P0039517,P0043485,and P0045762).
文摘Leveraging the unique features of light in biosafety,sensitivity,and resolution,optical technologies have seen a wide application in diagnosing and treating biological tissues,as well as in uncovering the mysteries and patterns of life.However,the application of light remains constrained in deep tissues,as researchers struggle to achieve the same or comparable high-resolution focusing and imaging as in superficial tissues.This limitation mainly arises from the spatial inhomogeneities of refractive index(RI)in biological tissues,where light propagation is severely hindered by scattering and absorption.
基金supported by National Natural Science Foundation of China(NSFC)(81930048,81627805)Hong Kong Research Grant Council(15217721,R5029-19,C7074-21GF)+3 种基金Hong Kong Innovation and Technology Commission(GHP/043/19SZ,GHP/044/19GD)Guangdong Science and Technology Commission(2019A1515011374,2019BT02X105)National Research Foundation of Korea(2015R1A3A2066550,2021R1A2C3012903)Institute of Information&Communications Technology Planning&Evaluation(IITP,2021-0-00745)grant funded by the Korea government(MSIT).
文摘Optical techniques offer a wide variety of applications as light-matter interactions provide extremely sensitive mechanisms to probe or treat target media.Most of these implementations rely on the usage of ballistic or quasi-ballistic photons to achieve high spatial resolution.However,the inherent scattering nature of light in biological tissues or tissue-like scattering media constitutes a critical obstacle that has restricted the penetration depth of non-scattered photons and hence limited the implementation of most optical techniques for wider applications.In addition,the components of an optical system are usually designed and manufactured for a fixed function or performance.Recent advances in wavefront shaping have demonstrated that scattering-or component-induced phase distortions can be compensated by optimizing the wavefront of the input light pattern through iteration or by conjugating the transmission matrix of the scattering medium.
