Objective: To study the ERK expression and its significance in the development of human rectal carcinoma. Methods: Samples were obtained from 62 patients with rectal carcinoma, including tumor tissue and adjacent norm...Objective: To study the ERK expression and its significance in the development of human rectal carcinoma. Methods: Samples were obtained from 62 patients with rectal carcinoma, including tumor tissue and adjacent normal rectal tissue. Western blot was used to measure the expression of ERK-1 and ERK-2. S-P immunohistochemical method was used to count the microvessel density (MVD). Results: ERK-1 and ERK-2 protein levels were increased in rectal carcinoma tissue compared with those in adjacent normal tissues (t = 2.980 and 2.194, P < 0.01 and 0.05 respectively). The MVD was higher in patients with higher ERK-1 and/or ERK-2 protein levels than that in cases with lower ERK-1 and/or ERK-2 levels. Conclu- sion: Overexpression of ERK-1 and/or ERK-2 may play an important role in the development of human rectal carcinoma, the overexpression can enhance the growth of tumor microvessel and promote the development of human rectal carcinoma.展开更多
基金Supported by a grant from the Foundation for Medical Scientific Research of Health Bureau of Guangdong Province (No. A2002449)
文摘Objective: To study the ERK expression and its significance in the development of human rectal carcinoma. Methods: Samples were obtained from 62 patients with rectal carcinoma, including tumor tissue and adjacent normal rectal tissue. Western blot was used to measure the expression of ERK-1 and ERK-2. S-P immunohistochemical method was used to count the microvessel density (MVD). Results: ERK-1 and ERK-2 protein levels were increased in rectal carcinoma tissue compared with those in adjacent normal tissues (t = 2.980 and 2.194, P < 0.01 and 0.05 respectively). The MVD was higher in patients with higher ERK-1 and/or ERK-2 protein levels than that in cases with lower ERK-1 and/or ERK-2 levels. Conclu- sion: Overexpression of ERK-1 and/or ERK-2 may play an important role in the development of human rectal carcinoma, the overexpression can enhance the growth of tumor microvessel and promote the development of human rectal carcinoma.
