Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptom...Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment.展开更多
Most Chinese readers are familiar with Xu Zhimo’s poem "Farewell to Cambridge". And the best footnote to this poem is his prose "The Cambridge I Know". He mentions quite a few places which leave h...Most Chinese readers are familiar with Xu Zhimo’s poem "Farewell to Cambridge". And the best footnote to this poem is his prose "The Cambridge I Know". He mentions quite a few places which leave him life-long impressions, including an old village named Grantchester. Having tea in an orchard there would bring one some unusual experience:展开更多
Shortly after I arrived at Cambridge, I went to the University Library to apply for a library card. At the very moment I stepped on the basement floor of the Library, where the administration office is located, I was ...Shortly after I arrived at Cambridge, I went to the University Library to apply for a library card. At the very moment I stepped on the basement floor of the Library, where the administration office is located, I was overwhelmed by a spectacular exhibition of medieval and Renaissance illuminated manuscripts. The most striking impressions展开更多
On December 24, 2005, it was freezing in Cambridge. Early in the morning I rushed to the King’ s College in order to gain admission into the Chapel. When I arrived there at 9 o’clock, there was already a long queue ...On December 24, 2005, it was freezing in Cambridge. Early in the morning I rushed to the King’ s College in order to gain admission into the Chapel. When I arrived there at 9 o’clock, there was already a long queue outside the Chapel. I was fully ready to queue for 5 hours with hundreds of other people coming from all over the world, not a few of them specially展开更多
One day in mid-June 2006 when I was on a visit to the Countryside Restoration Trust at Barton near Cambridge, Mr. Christopher Stevenson, the director of Program of Events for Newcomers & Academic Visitors, gave me...One day in mid-June 2006 when I was on a visit to the Countryside Restoration Trust at Barton near Cambridge, Mr. Christopher Stevenson, the director of Program of Events for Newcomers & Academic Visitors, gave me a letter enclosing a notice and a ticket I booked nearly two months earlier. He told me that I was very lucky because a strictly limited number of tickets had been allocated to academic visitors. It was a ticket to admit me to the Honorary Degree Congregation and to the reception afterwards on Tuesday 27 June.展开更多
In the middle of the last Lent Term, that was from January 17 to March 17, I noticed there were many different posters about May Balls. It seemed to me that more than half of the 31 Colleges in the University of Cambr...In the middle of the last Lent Term, that was from January 17 to March 17, I noticed there were many different posters about May Balls. It seemed to me that more than half of the 31 Colleges in the University of Cambridge would host May Balls, with prices ranging from around (?) 80 to (?)160. "Oh, it is so expensive! It cannot be simply a usual ball held in May. Shall I buy a ticket to any of the May Balls?" With this in my mind, I decided to ask my good friend Tina more about it. Tina has always been very helpful to me in understanding Cambridge traditions, and she never fails to solve my puzzles. From Tina’s explanation, together with my exploration into other sources, I get a picure of a Cambridge May Ball.展开更多
基金supported by the National Key Research and Development Project(2016YFC1301703)the Beijing Scientific and Technologic Project(D161100003816002).
文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment.
文摘Most Chinese readers are familiar with Xu Zhimo’s poem "Farewell to Cambridge". And the best footnote to this poem is his prose "The Cambridge I Know". He mentions quite a few places which leave him life-long impressions, including an old village named Grantchester. Having tea in an orchard there would bring one some unusual experience:
文摘Shortly after I arrived at Cambridge, I went to the University Library to apply for a library card. At the very moment I stepped on the basement floor of the Library, where the administration office is located, I was overwhelmed by a spectacular exhibition of medieval and Renaissance illuminated manuscripts. The most striking impressions
文摘On December 24, 2005, it was freezing in Cambridge. Early in the morning I rushed to the King’ s College in order to gain admission into the Chapel. When I arrived there at 9 o’clock, there was already a long queue outside the Chapel. I was fully ready to queue for 5 hours with hundreds of other people coming from all over the world, not a few of them specially
文摘One day in mid-June 2006 when I was on a visit to the Countryside Restoration Trust at Barton near Cambridge, Mr. Christopher Stevenson, the director of Program of Events for Newcomers & Academic Visitors, gave me a letter enclosing a notice and a ticket I booked nearly two months earlier. He told me that I was very lucky because a strictly limited number of tickets had been allocated to academic visitors. It was a ticket to admit me to the Honorary Degree Congregation and to the reception afterwards on Tuesday 27 June.
文摘In the middle of the last Lent Term, that was from January 17 to March 17, I noticed there were many different posters about May Balls. It seemed to me that more than half of the 31 Colleges in the University of Cambridge would host May Balls, with prices ranging from around (?) 80 to (?)160. "Oh, it is so expensive! It cannot be simply a usual ball held in May. Shall I buy a ticket to any of the May Balls?" With this in my mind, I decided to ask my good friend Tina more about it. Tina has always been very helpful to me in understanding Cambridge traditions, and she never fails to solve my puzzles. From Tina’s explanation, together with my exploration into other sources, I get a picure of a Cambridge May Ball.
