Background:To evaluate the clinical characteristics,risk factors,and treatment outcomes of fungal keratitis(FK)caused by three common fungal species in northern China.Methods:A total of 203 cases of FK caused by Fusar...Background:To evaluate the clinical characteristics,risk factors,and treatment outcomes of fungal keratitis(FK)caused by three common fungal species in northern China.Methods:A total of 203 cases of FK caused by Fusarium,Aspergillus or Alternaria treated at Shandong Eye Institute were included.Clinical features were analyzed in the following aspects:(I)risk factors,including physical trauma,ocular surface diseases,contact lens wear,and non-identified risk factors;(II)clinical manifestations;(III)treatment approaches and prognosis.Results:There were 151 cases of Fusarium keratitis,35 cases of Aspergillus keratitis,and 17 cases of Alternaria keratitis.Trauma(71.9%)ranked first among the risk factors for all 3 kinds of FK(P=0.015).Plant matter was most common in FK caused by Fusarium(54.1%)and Alternaria(63.6%),while grit was predominant in Aspergillus keratitis(61.5%).The main clinical manifestations were pseudopodia(74.2%in Fusarium keratitis and 64.7%in Alternaria keratitis)and hypopyon(51.4%in Aspergillus keratitis).The lesion area was less than 10 mm2 in 64.7%of Alternaria infection and more than 10 mm2 in 60.9%of Fusarium infection.Recurrence was found in Fusarium(9.9%)and Aspergillus(5.7%)keratitis,but not in Alternaria keratitis.Conclusions:FK associated with Fusarium,Aspergillus,and Alternaria seems to have various risk factors,clinical characteristics,and prognoses.Awareness of the specific differences may help to guide the clinical treatment before the results of culture and susceptibility testing are available.展开更多
It is our pleasure to offer the reader this special issue of the Annals of Eye Science that focuses on bioengineered cornea.Corneal disease is referred as one of the leading causes of blindness,only secondary to catar...It is our pleasure to offer the reader this special issue of the Annals of Eye Science that focuses on bioengineered cornea.Corneal disease is referred as one of the leading causes of blindness,only secondary to cataract in overall importance.The majority of corneal blind patients could potentially have their sight restored through corneal transplantation,whereas the barrier to the performance of corneal transplantation in many counties is the limited tissue availability.On a global level,there were an estimated 12.7 million people on the waiting lists for corneal transplants in 2012,and China had more than 3 million with its prevalence at 0.225%.What is more,the number of corneal blind patients in China is still increasing by 10%annually.In spite of large population of corneal blind patients in China,only fewer than 8,000 corneal transplantations were performed in 2012.展开更多
基金This study was supported by National Natural Science Foundation of China(82070923,81870639)Key Project of National Natural Science Foundation of China(81530027)+1 种基金Taishan Scholar Program(20150215,201812150)the Innovation Project of Shandong Academy of Medical Sciences,Academic Promotion Programme of Shandong First Medical University(2019RC009).
文摘Background:To evaluate the clinical characteristics,risk factors,and treatment outcomes of fungal keratitis(FK)caused by three common fungal species in northern China.Methods:A total of 203 cases of FK caused by Fusarium,Aspergillus or Alternaria treated at Shandong Eye Institute were included.Clinical features were analyzed in the following aspects:(I)risk factors,including physical trauma,ocular surface diseases,contact lens wear,and non-identified risk factors;(II)clinical manifestations;(III)treatment approaches and prognosis.Results:There were 151 cases of Fusarium keratitis,35 cases of Aspergillus keratitis,and 17 cases of Alternaria keratitis.Trauma(71.9%)ranked first among the risk factors for all 3 kinds of FK(P=0.015).Plant matter was most common in FK caused by Fusarium(54.1%)and Alternaria(63.6%),while grit was predominant in Aspergillus keratitis(61.5%).The main clinical manifestations were pseudopodia(74.2%in Fusarium keratitis and 64.7%in Alternaria keratitis)and hypopyon(51.4%in Aspergillus keratitis).The lesion area was less than 10 mm2 in 64.7%of Alternaria infection and more than 10 mm2 in 60.9%of Fusarium infection.Recurrence was found in Fusarium(9.9%)and Aspergillus(5.7%)keratitis,but not in Alternaria keratitis.Conclusions:FK associated with Fusarium,Aspergillus,and Alternaria seems to have various risk factors,clinical characteristics,and prognoses.Awareness of the specific differences may help to guide the clinical treatment before the results of culture and susceptibility testing are available.
文摘It is our pleasure to offer the reader this special issue of the Annals of Eye Science that focuses on bioengineered cornea.Corneal disease is referred as one of the leading causes of blindness,only secondary to cataract in overall importance.The majority of corneal blind patients could potentially have their sight restored through corneal transplantation,whereas the barrier to the performance of corneal transplantation in many counties is the limited tissue availability.On a global level,there were an estimated 12.7 million people on the waiting lists for corneal transplants in 2012,and China had more than 3 million with its prevalence at 0.225%.What is more,the number of corneal blind patients in China is still increasing by 10%annually.In spite of large population of corneal blind patients in China,only fewer than 8,000 corneal transplantations were performed in 2012.
