Photocatalytic degradation of organic pollutants by MOFs based materials:A review

Metal-organic frameworks(MOFs)are currently popular porous materials with research and application value in various fields.Aiming at the application of MOFs in photocatalysis,this paper mainly reviews the main synthesis methods of MOFs and the latest research progress of MOFs-based photocatalysts to degrade organic pollutants in water,such as organic dyes,pharmaceuticals and personal care products,and other organic pollutants.The main characteristics of different synthesis methods of MOFs,the main design strategies of MOFs-based photocatalysts,and the excellent performance of photocatalytic degradation of organic pollutants are summarized.At the end of this paper,the practical application of MOFs,the current limitations of MOFs,the synthesis methods of MOFs,and the future development trend of MOFs photocatalysts are explained.

Evaluation of pharmaceutical activities of G-protein coupled receptor targeted pharmaceuticals in Chinese wastewater effluent

The occurre nce of biologically active pharmaceuticals in aquatic enviro nments raised the potential risks to aquatic species.Among these marketed biological active pharmaceuticals,it has been estimated that40%of them target G-protein-coupled receptors(GPCRs).We have illustrated pharmaceutical activities of GPCR targeted pharmaceuticals in English and Japanese wastewater by the in vitro transforming growth factor-α(TGFα)shedding assay.However,as the most important producer and consumer of pharmaceuticals,the occurrence of GPCR targeted pharmaceuticals in China had remained unclear.In this study,we investigated the pharmaceutical activities of GPCR targeted pharmaceuticals in secondary effluents of Chinese wastewater treatment plants.We discovered antagonistic activities against angiotensin(AT1)receptor at up to 7.2×102 ng-valsartan-equivalent quantity/L in Chinese wastewater for the first time as well as agonistic activities against dopamine(D2)receptor.Furthermore,in parallel with the assay,we determined concentrations of GPCR targeted pharmaceuticals in target wastewater by liquid chromatography coupled with tandem mass spectrometry(LC-MS/MS).Through the comparison of predicted antagonistic activities calculated by concentrations and potency values from the assay,we found that the measured antagonistic activities against AT1 receptor from the assay were higher than the predicted AT1 activities from valsartan,irbesartan,and losartan,indicating the potential existence of other unknown AT1 antagonists in wastewater.