A series of novel 3-alkylthio-4-arylideneamino-5-(2-furyl)-1, 2, 4-triazole derivatives were synthesized. Their chemical structures were confirmed with elemental analysis and spectral data. Endothelin(ET) receptor c...A series of novel 3-alkylthio-4-arylideneamino-5-(2-furyl)-1, 2, 4-triazole derivatives were synthesized. Their chemical structures were confirmed with elemental analysis and spectral data. Endothelin(ET) receptor competitive binding assay showed that some compounds exhibited high selective as potent ET-1 receptor antagonist.展开更多
As an important intermediate to study cyclin-dependent kinase （CDK） inhibitors, 2-ary1-8-（piperidin-4-y1）-5,7-dimethoxy-4H- chromen-4-one derivatives were prepared using 13-diketone route with low yield. In our st...As an important intermediate to study cyclin-dependent kinase （CDK） inhibitors, 2-ary1-8-（piperidin-4-y1）-5,7-dimethoxy-4H- chromen-4-one derivatives were prepared using 13-diketone route with low yield. In our study, chalcone route has been investigated and the result suggested that the benzaldehydes substituted with electron-donating group give much better yield than β-diketone route. This new method will be an efficient way to start further research on new anticancer flavonoids.展开更多
文摘A series of novel 3-alkylthio-4-arylideneamino-5-(2-furyl)-1, 2, 4-triazole derivatives were synthesized. Their chemical structures were confirmed with elemental analysis and spectral data. Endothelin(ET) receptor competitive binding assay showed that some compounds exhibited high selective as potent ET-1 receptor antagonist.
基金We are grateful to the National Natural Science Foundation of China （No. 20272033） for financial support for this work.
文摘As an important intermediate to study cyclin-dependent kinase （CDK） inhibitors, 2-ary1-8-（piperidin-4-y1）-5,7-dimethoxy-4H- chromen-4-one derivatives were prepared using 13-diketone route with low yield. In our study, chalcone route has been investigated and the result suggested that the benzaldehydes substituted with electron-donating group give much better yield than β-diketone route. This new method will be an efficient way to start further research on new anticancer flavonoids.
