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IASB发展现状、未来趋势与我国会计国际话语权的提升
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作者 曾峻 王雨琪 +2 位作者 文欢 逄宇彤 吴家乐 《湖南财政经济学院学报》 2023年第6期54-64,共11页
目前全球会计治理体系中最主要的决策和执行机构是国际会计理事会(IASB),在多年的发展中,IASB为会计准则国际趋同作出重大贡献。然而,随着科技进步和产业革命重塑了世界经济和贸易格局,大国之间的战略博弈加剧推动了国际政治和治理体系... 目前全球会计治理体系中最主要的决策和执行机构是国际会计理事会(IASB),在多年的发展中,IASB为会计准则国际趋同作出重大贡献。然而,随着科技进步和产业革命重塑了世界经济和贸易格局,大国之间的战略博弈加剧推动了国际政治和治理体系的变革,IASB面临着改革和发展的巨大压力。因此,在人类命运共同体思想的指导下,我们应该把握全球会计治理变革的历史潮流,积极参与全球会计治理体系的变革和建设,提升我国会计国际话语权,有效维护我国在全球会计治理过程中的国家利益,推动全球会计治理体系向更加公正合理的方向发展。这是我们整个会计行业实务界和学术界在未来一定时期的奋斗目标。 展开更多
关键词 IASB 人类命运共同体 国际话语权
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肺癌组织中DNA聚合酶β基因突变的研究
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作者 吴青峻 田文鑫 +8 位作者 于瀚博 黄川 焦鹏 马超 王永忠 黄文 孙耀光 艾斌 佟宏峰 《中国肺癌杂志》 CAS CSCD 北大核心 2019年第7期427-432,共6页
背景与目的 DNA聚合酶β是参与DNA损伤修复的关键酶之一,国外有学者认为其编码基因Polb在30%的肿瘤中存在遗传突变,但受到所用标本量的限制,这一结论是否准确尚无定论。本研究基于基因测序技术,通过对69例肺癌患者组织标本的基因筛查,... 背景与目的 DNA聚合酶β是参与DNA损伤修复的关键酶之一,国外有学者认为其编码基因Polb在30%的肿瘤中存在遗传突变,但受到所用标本量的限制,这一结论是否准确尚无定论。本研究基于基因测序技术,通过对69例肺癌患者组织标本的基因筛查,旨在明确DNA聚合酶β的基因突变在中国汉族人群肺癌患者中的发生频率。方法利用盐析法提取69例肺癌患者的癌及癌旁组织基因组DNA,并用于扩增Polb基因全部14个外显子区及启动子区。通过与NCBI数据库中野生型基因序列进行比对,系统分析肺癌组织中的Polb基因突变及其频率。结果相对于野生型,本研究共发现5种突变类型,其中3种(-196G>T,-188_-187insCGCCC,-168C>A)位于启动子区,2种(587C>G, 612A>T)位于外显子区,突变类型-188_-187insCGCCC和587C>G尚未见文献报道,后者可引起第196位氨基酸由苏氨酸突变为丝氨酸。另一方面,癌和癌旁组中均可检测到所有5种突变类型,提示这些突变并非肺癌组织所特有。结论肺癌组织中未发现特异性表达的Polb基因突变位点,Polb基因突变可能不是中国汉族肺癌患者的肿瘤标志物。 展开更多
关键词 DNA聚合酶Β 肺肿瘤 PCR扩增 突变分析
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基于双分支网络的图像修复取证方法
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作者 章登勇 文凰 +4 位作者 李峰 曹鹏 向凌云 杨高波 丁湘陵 《网络与信息安全学报》 2022年第6期110-122,共13页
图像修复是一项利用图像已知区域的信息来修复图像中缺失或损坏区域的技术。人们借助以此为基础的图像编辑软件无须任何专业基础就可以轻松地编辑和修改数字图像内容,一旦图像修复技术被用于恶意移除图像的内容,会给真实的图像带来信任... 图像修复是一项利用图像已知区域的信息来修复图像中缺失或损坏区域的技术。人们借助以此为基础的图像编辑软件无须任何专业基础就可以轻松地编辑和修改数字图像内容,一旦图像修复技术被用于恶意移除图像的内容,会给真实的图像带来信任危机。目前图像修复取证的研究只能有效地检测某一种类型的图像修复。针对这一问题,提出了一种基于双分支网络的图像修复被动取证方法。双分支中的高通滤波卷积网络先使用一组高通滤波器来削弱图像中的低频分量,然后使用4个残差块提取特征,再进行两次4倍上采样的转置卷积对特征图进行放大,此后使用一个5×5的卷积来减弱转置卷积带来的棋盘伪影,生成图像高频分量上的鉴别特征图。双分支中的双注意力特征融合分支先使用预处理模块为图像增添局部二值模式特征图。然后使用双注意力卷积块自适应地集成图像局部特征和全局依赖,捕获图像修复区域和原始区域在内容及纹理上的差异,再对双注意力卷积块提取的特征进行融合。最后对特征图进行相同的上采样,生成图像内容和纹理上的鉴别特征图。实验结果表明该方法在检测移除对象的修复区域上,针对样本块修复方法上检测的F1分数较排名第二的方法提高了2.05%,交并比上提高了3.53%;针对深度学习修复方法上检测的F1分数较排名第二的方法提高了1.06%,交并比提高了1.22%。对结果进行可视化可以看出,在检测修复区域上能够准确地定位移除对象的边缘。 展开更多
关键词 图像取证 图像修复检测 深度学习 注意力机制
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单操作孔胸腔镜胸腺扩大切除治疗重症肌无力:附45例报告 被引量:3
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作者 黄川 佟宏峰 +7 位作者 孙耀光 吴青峻 马超 焦鹏 田文鑫 于瀚博 黄文 王永忠 《中国肺癌杂志》 CAS CSCD 北大核心 2020年第3期156-161,共6页
背景与目的胸腺切除已成为重症肌无力(myasthenia gravis, MG)治疗的重要组成部分,近年来,经电视胸腔镜(video-assisted thoracoscopic surgery, VATS)胸腺扩大切除得到广泛应用。传统VATS术式多需3个经肋间切口,本研究改良了手术入路... 背景与目的胸腺切除已成为重症肌无力(myasthenia gravis, MG)治疗的重要组成部分,近年来,经电视胸腔镜(video-assisted thoracoscopic surgery, VATS)胸腺扩大切除得到广泛应用。传统VATS术式多需3个经肋间切口,本研究改良了手术入路和操作方式,现总结单操作孔VATS胸腺扩大切除治疗MG的效果。方法回顾性分析2017年7月-2018年12月北京医院胸外科应用单操作孔VATS行胸腺扩大切除术的45例MG患者资料,总结其手术安全性和疗效。结果本组45例均顺利完成胸腺扩大切除,无中转开胸、增加切口和围术期死亡,平均手术时间(141.3±39.2)min,平均术中出血量(64.2±45.5)m L,中位胸腔引流管留置时间3 d,平均胸腔引流量(890.4±439.1)m L,中位术后住院时间6 d。围术期并发症13例(28.9%),其中肌无力危象5例(11.1%),肺部并发症6例(13.3%),切口愈合不良4例(8.9%),房颤4例(8.9%),迟发性心包积血1例(2.2%)。中位随访时间18.5个月,统计术后1年的疗效,药物缓解1例(2.2%),微小症状表现18例(40.0%),改善23例(51.1%),无变化1例(2.2%),加重2例(4.4%)。结论单操作孔胸腔镜下胸腺扩大切除术治疗MG的手术安全性和疗效良好,围术期应注意预防肌无力危象、肺部并发症和切口并发症。 展开更多
关键词 重症肌无力 胸腺扩大切除 电视胸腔镜 单操作孔
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Assessing the numbers of SNPs needed to establish molecular IDs and characterize the genetic diversityof soybean cultivars derived from Tokachi nagaha 被引量:12
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作者 Zhangxiong Liu Jun Li +11 位作者 Xuhong Fan Nang Myint Phyu Sin Htwe Shuming Wang wen huang Jiyu Yang Lili Xing Lijun Chen Yinghui Li Rongxia Guan Ruzhen Chang Dechun Wang Lijuan Qiu 《The Crop Journal》 SCIE CAS CSCD 2017年第4期326-336,共11页
The development of a core set of SNP molecular markers that could be widely used in soybean genetic research would greatly facilitate research into the genetic diversity of soybean.We conducted an analysis of Tokachi ... The development of a core set of SNP molecular markers that could be widely used in soybean genetic research would greatly facilitate research into the genetic diversity of soybean.We conducted an analysis of Tokachi nagaha and 137 of its descendant soybean cultivars using 4044 SNP markers with the goal of determining the appropriate number of single-nucleotide polymorphisms(SNPs)needed to construct unambiguous molecular IDs and characterize genetic diversity based on a genetic distance matrix correlation method.When the number of SNPs was held constant,the number of accession pairs that could be distinguished increased as the polymorphism informative content(PIC)value of the SNPs increased.A core panel of 20 selected SNPs from 11 linkage groups with a mean PIC value of 0.3703 and a range of 0.3640–0.3749 was able to identify almost all of the accession pairs in our study[9445 pairs(99.92%)].The eight accession pairs that could not be identified with this core SNP set all originated from the same province and some of them had the same parental cultivars.The molecular IDs of the 138 accessions were constructed using the core 20 SNPs.It is known that both the number of SNPs and PIC values should be considered when SNPs are selected for use in the analysis of genetic diversity.In this study,when the PIC value was 0.3460,the correlation coefficient between the genetic distance matrices associated with a panel of 200 SNPs and the total population was>0.800,indicating satisfactory correlation.Our high-accuracy,high-resolution core SNP panel for germplasm fingerprinting and our findings about assessing genetic diversity will likely markedly improve the management and utilization efficiency of soybean germplasm resources. 展开更多
关键词 SOYBEAN SNP GENETIC diversity GENETIC DISTANCE Molecular ID
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Laparoscopy-assisted total gastrectomy with trans-orally inserted anvil(OrVil^(TM)):A single institution experience 被引量:11
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作者 Guan-Qun Liao Xiao-Wei Ou +2 位作者 Shi-Qiang Liu Shao-Rui Zhang wen huang 《World Journal of Gastroenterology》 SCIE CAS 2013年第5期755-760,共6页
AIM:To investigate the feasibility of laparoscopyassisted total gastrectomy(LATG)using trans-orally inserted anvil(OrVilTM)in terms of operative characteristics and short term outcomes. RESULTS:Characteristics of 27 p... AIM:To investigate the feasibility of laparoscopyassisted total gastrectomy(LATG)using trans-orally inserted anvil(OrVilTM)in terms of operative characteristics and short term outcomes. RESULTS:Characteristics of 27 patients with gastric cancer who underwent LATG from October 2009 to October 2012 in the Foshan Affiliated Hospital of South Medical University were retrospectively reviewed. Among these patients,six were reconstructed by minilaparotomy and 21 by OrVilTM.The clinicopathological characteristics,total operation time,total blood loss, abdominal incision and complications of anastomosis including stenosis and leakage,were compared between the groups undergoing LATG with OrVilTM and the group undergoing minilaparotomy. RESULTS:The operations were successfully performed on all the patients without intraoperative complications or conversion to open surgery.Two(10%)patients received palliative procedure under laparoscope who were prepared for LATG preoperatively.One case had hepatic metastatic carcinoma and 1 case had tumor recurrence near the anastomosis 8 mo after surgery.The mean follow-up duration was 10 mo(range,2-24 mo). Operation time was significantly reduced by the use of OrVilTM(198.42±30.28 min vs 240.83±8.23 min). The postoperative course with regard to occurrence of stenosis and leakage was not different between the two groups.There were no significant differences in estimated blood loss.The upper abdominal incision was smaller in OrVilTM group than in minilaparotomy group (4.31±0.45 cm vs 6.43±0.38 cm). CONCLUSION:LATG using OrVil TM is a technically feasible surgical procedure with sufficient lymph node dissection,less operation time and acceptable morbidity. 展开更多
关键词 TOTAL GASTRECTOMY ESOPHAGOJEJUNOSTOMY Laparoscopy-assisted TOTAL GASTRECTOMY Reconstruction OrVilTM
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Effects of IBA on the rooting of branch cuttings of Chinese jujube (Zizyphus jujuba Mill.) and changes to nutrients and endogenous hormones 被引量:8
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作者 Fengxia Shao Sen Wang +1 位作者 wen huang Zhiming Liu 《Journal of Forestry Research》 SCIE CAS CSCD 2018年第6期1557-1567,共11页
‘Zhongqiusucui’ jujube secondary shoots were treated with 3-indolebutyric acid(IBA) at three concentrations, 500, 1000 and 1500 mg/L. Results show that IBA could significantly enhance rooting and root characteristic... ‘Zhongqiusucui’ jujube secondary shoots were treated with 3-indolebutyric acid(IBA) at three concentrations, 500, 1000 and 1500 mg/L. Results show that IBA could significantly enhance rooting and root characteristics of cuttings and were best with IBA at 1500 mg/L. In the rooting process, the formation of adventitious roots was related to the consumption and accumulation of nutrients(soluble sugars and proteins) and the changes in endogenous hormones in phloem, leaf tips and leaf bases. The rooting of cuttings had a positive correlation with the consumption of soluble sugars during the period of callus formation and with the accumulation of soluble sugars during adventitious root formation and growth. Rooting was positively related to the breakdown of soluble proteins in the phloem when the callus formed, and had a positive correlation with its accumulation during adventitious root formation and growth. Leaf tips and leaf bases showed a reverse trend in changes of soluble protein. However, together with the phloem, leaf tips and leaf bases regulated and controlled the formation and development of adventitious roots. The main activities of soluble proteins exist in the leaf tips as this was the main source of soluble proteins. The relation between rooting and IAA(indole-3-acetic acid) content in phloem was positive and thus a high concentration of IAA could benefit the induction and formation of adventitious roots. However, rooting was negatively related with ABA(abscisic acid) and GA(gibberellic acid) and a high concentration of both could inhibit the induction and formation of adventitious roots. Rooting had a positive correlation with phloem IAA/ABA ratios, and higher ratios could improve rooting. Low concentrations of ZR(zeatin riboside) triggered the induction of adventitious roots, while higher concentrations promoted root growth.Endogenous hormones in leaf tips and bases had an impact on rooting. The activities of endogenous hormones mainly existed in leaf tips because they play a major role in the production and consumption of IAA and its ABA content increased during rooting. The ZR in leaf tips influenced the rooting of cuttings, especially in the callus formation and rooting stage. Leaf tips were the main source of GA. 展开更多
关键词 Chinese jujube Ziziphus jujuba Mill. Rooting of cuttings Soluble sugars Soluble proteins Endogenous hormones
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喷涂工艺参数对等离子喷涂CoCrAlTaY-Al2O3涂层的微观组织结构和力学性能的影响 被引量:6
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作者 黄付友 薛召露 +6 位作者 黄文 温永红 倪振航 王硕煜 刘侠 吴朝军 张世宏 《热喷涂技术》 2019年第4期38-46,37,共10页
为提高连续退火炉高温炉辊的表面质量,采用大气等离子喷涂技术制备了CoCrAlTaY-30%Al2O3涂层,研究了喷涂工艺参数对涂层微观组织结构、相组成和力学性能的影响。结果表明:等离子喷涂CoCrAlTaY-Al2O3涂层中两种典型组织Al2O3相和合金相... 为提高连续退火炉高温炉辊的表面质量,采用大气等离子喷涂技术制备了CoCrAlTaY-30%Al2O3涂层,研究了喷涂工艺参数对涂层微观组织结构、相组成和力学性能的影响。结果表明:等离子喷涂CoCrAlTaY-Al2O3涂层中两种典型组织Al2O3相和合金相交互存在并分散较均匀,涂层主要由Co合金、α-Al2O3、γ-Al2O3物相组成;喷涂功率、喷涂距离和主气流量均对涂层的微观组织和物相无明显影响;随着喷涂功率的提高,粉末粒子的熔化效果变好、孔隙率降低,在40 kW喷涂功率下,涂层的硬度最高,此时结合强度达到68 MPa;在80~140 mm喷涂距离范围内,粉末大部分已熔化,有少量的未熔颗粒存在,在喷涂距离为120 mm时涂层表面光滑致密,孔隙率较低,结合强度最大为78.6 MPa;主气流量为40L/min时,涂层的孔隙率最小而结合强度最大。等离子喷涂CoCrAlTaY-Al2O3涂层的最优工艺参数为喷涂功率40 kW、喷涂距离120 mm、主气流量40 L/min,得到的涂层孔隙率为3.689%、硬度为HV0.3664.9、拉伸强度78.6 MPa。 展开更多
关键词 高温炉辊 CoCrAlTaY-Al2O3涂层 大气等离子喷涂 微观组织结构 力学性能
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Memristive Artificial Synapses for Neuromorphic Computing 被引量:8
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作者 wen huang Xuwen Xia +6 位作者 Chen Zhu Parker Steichen Weidong Quan Weiwei Mao Jianping Yang Liang Chu Xing’ao Li 《Nano-Micro Letters》 SCIE EI CAS CSCD 2021年第5期218-245,共28页
Neuromorphic computing simulates the operation of biological brain function for information processing and can potentially solve the bottleneck of the von Neumann architecture.This computing is realized based on memri... Neuromorphic computing simulates the operation of biological brain function for information processing and can potentially solve the bottleneck of the von Neumann architecture.This computing is realized based on memristive hardware neural networks in which synaptic devices that mimic biological synapses of the brain are the primary units.Mimicking synaptic functions with these devices is critical in neuromorphic systems.In the last decade,electrical and optical signals have been incorporated into the synaptic devices and promoted the simulation of various synaptic functions.In this review,these devices are discussed by categorizing them into electrically stimulated,optically stimulated,and photoelectric synergetic synaptic devices based on stimulation of electrical and optical signals.The working mechanisms of the devices are analyzed in detail.This is followed by a discussion of the progress in mimicking synaptic functions.In addition,existing application scenarios of various synaptic devices are outlined.Furthermore,the performances and future development of the synaptic devices that could be significant for building efficient neuromorphic systems are prospected. 展开更多
关键词 Synaptic devices Neuromorphic computing Electrical pulses Optical pulses Photoelectric synergetic effects
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Laser test of the prototype of CEE time projection chamber 被引量:5
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作者 wen huang Fei Lu +22 位作者 He Li He Dong Yong-jin Ye Chen-Sheng Zhou Long-Xiang Liu Long Du Xiao-Hai Jin Peng-Liu Jin-Hui Chen Song Zhang Chen Zhong Chen Wu Qi-Te Li Hong-Liang Zang Yu-Cheng Ge Cheng-Jian Lin Hui-Ming Jia Nan-Ru Ma Dong-Xi Wang Peng Ma Jun Xu De-Qing Fang Yu-Gang Ma 《Nuclear Science and Techniques》 SCIE CAS CSCD 2018年第3期138-142,共5页
A prototype thick-GEM-based cooling storage ring external-target experiment(CEE) time projection chamber(TPC) is constructed and tested with the pulsed ultraviolet laser beams. The results indicate that the prototype ... A prototype thick-GEM-based cooling storage ring external-target experiment(CEE) time projection chamber(TPC) is constructed and tested with the pulsed ultraviolet laser beams. The results indicate that the prototype TPC has a good performance in three-dimensional track resolution. In X direction the position resolution is about 0.2 mm, and in Y direction the position resolution is about 0.5 mm. The results also determine that the energy resolution is about 5.4%, which achieve the requirements of the CEE experiment and can be used to study the nuclear state equation and the quantum chromo dynamics. 展开更多
关键词 TPC THICK GEM LASER TEST Track RESOLUTION Energy RESOLUTION
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肺癌合并间质性肺病的外科治疗 被引量:3
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作者 黄川 马超 +7 位作者 吴青峻 焦鹏 孙耀光 田文鑫 于瀚博 黄文 王永忠 佟宏峰 《中国肺癌杂志》 CAS CSCD 北大核心 2020年第5期343-350,共8页
背景与目的间质性肺病(interstitial lung disease,ILD)是一组主要累及肺间质和肺泡腔导致肺泡-毛细血管功能单位丧失的弥漫性肺疾病,常导致限制性通气功能障碍和弥散功能障碍。ILD基础上肺癌发病率增高,肺癌合并间质性肺病(lung cancer... 背景与目的间质性肺病(interstitial lung disease,ILD)是一组主要累及肺间质和肺泡腔导致肺泡-毛细血管功能单位丧失的弥漫性肺疾病,常导致限制性通气功能障碍和弥散功能障碍。ILD基础上肺癌发病率增高,肺癌合并间质性肺病(lung cancer combined with ILD,LC-ILD)的手术风险明显增加。本研究旨在探讨LC-ILD外科治疗的安全性,总结围术期诊治经验。方法回顾性分析2012年1月-2019年12月北京医院胸外科收治的LC-ILD行肺切除术的患者资料,总结其临床表现、影像、病理、手术安全性、围术期并发症和诊治经验。结果本研究共纳入23例患者,男性20例(87.0%),平均年龄(69.1±7.8)岁,吸烟者19例(82.6%)。ILD类型包括特发性肺纤维化14例(60.9%)、特发性非特异性间质性肺炎7例(30.4%)、结缔组织病相关ILD 2例(8.7%)。肺癌病理包括腺癌7例(30.4%)、小细胞癌7例(30.4%)、鳞癌6例(26.1%)、小细胞癌混合鳞癌1例(4.3%)、大细胞癌2例(8.7%)。手术入路包括经电视胸腔镜16例(69.6%)和前外侧开胸7例(30.4%),切除方式包括肺叶切除13例(56.5%)、双肺叶切除1例(4.3%)和亚肺叶切除9例(39.1%)。术后90 d并发症11例(47.8%),其中肺部并发症8例(34.8%),ILD急性加重(acute exacerbation of ILD,AE-ILD)4例(17.4%),心房纤颤6例(26.1%),急性左心功能不全1例(4.3%)。术后90 d死亡2例(8.7%),死因均为AE-ILD。结论LC-ILD以合并症多、肺功能差的高龄患者居多,手术风险明显增高。术前应充分控制ILD病情,术中尽量降低手术创伤,术后应特别关注肺部并发症和AE-ILD。AEILD预后差,治疗难度大,糖皮质激素有助于改善病情,早诊早治是治疗关键。 展开更多
关键词 肺疾病 肺肿瘤 肺切除术 治疗结果
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One-step fabrication of TiO2/graphene hybrid mesoporous film with enhanced photocatalytic activity and photovoltaic performance 被引量:2
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作者 Junxiong Guo Yiyi Li +6 位作者 Shangdong Li Xumei Cui Yu Liu wen huang Linna Mao Xiongbang Wei Xiaosheng Zhang 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 北大核心 2020年第8期1208-1216,共9页
We synthesized a mesoporous film based on TiO2-reduced graphene oxide(RGO)hybrids using a one-step vapor-thermal method without the need for an additional annealing process.The vapor-thermally prepared TiO2-graphene h... We synthesized a mesoporous film based on TiO2-reduced graphene oxide(RGO)hybrids using a one-step vapor-thermal method without the need for an additional annealing process.The vapor-thermally prepared TiO2-graphene hybrid(VTH)features unique structures with an ultra-large specific surface area of^260 m^2 g^-1 and low aggregation,giving rise to enhanced light harvesting and increased charge generation and separation efficiency.It was observed that a mesoporous film with uniform pore distribution is simultaneously obtained during the VTH growth process.When a 5.0 wt%RGO VTH film was used as the active layer in photocatalysis,the highest photocatalytic activity for degradation of methyl orange was achieved.For another,when a 0.75 wt%RGO VTH film was used as the photoanode in a dye-sensitized solar cell,the power conversion efficiency reached 7.58%,which represents an increase of 73.1%compared to a solar cell using an a photoanode of pure TiO2 synthesized by a traditional solvothermal method.It is expected that this facile method for the synthesis of TiO2/graphene hybrid mesoporous films will be useful in practical applications for preparing other metal oxide/graphene hybrids with ultra-high photocatalytic activity and photovoltaic performance. 展开更多
关键词 TiO2-graphene hybrid Catalytic activity PHOTOANODE Vapor-thermal method Mesoporous film
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Efficacy and safety of laparoscopic radical resection following neoadjuvant therapy for pancreatic ductal adenocarcinoma:A retrospective study 被引量:2
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作者 Yong-Gang He Xiao-Bing huang +5 位作者 Yu-Ming Li Jing Li Xue-Hui Peng wen huang Yi-Chen Tang Lu Zheng 《World Journal of Gastrointestinal Oncology》 SCIE 2022年第9期1785-1797,共13页
BACKGROUND Multiple studies have demonstrated that neoadjuvant chemotherapy(NACT) can prolong the overall survival of pancreatic ductal adenocarcinoma(PDAC) patients. However, most studies have focused on open surgery... BACKGROUND Multiple studies have demonstrated that neoadjuvant chemotherapy(NACT) can prolong the overall survival of pancreatic ductal adenocarcinoma(PDAC) patients. However, most studies have focused on open surgery following NACT.AIM To investigate the efficacy and safety of laparoscopic radical resection following NACT for PDAC.METHODS We retrospectively analyzed the clinical data of 15 patients with pathologically confirmed PDAC who received NACT followed by laparoscopic radical surgery in our hospital from December 2019 to April 2022. All patients underwent abdominal contrast-enhanced computed tomography(CT) and positron emission tomography-CT before surgery to accurately assess tumor stage and exclude distant metastasis.RESULTS All 15 patients with pancreatic cancer were successfully converted to surgical resection after NACT, including 8 patients with pancreatic head cancer and 7 patients with pancreatic body and tail cancer. Among them, 13 patients received the nab-paclitaxel plus gemcitabine regimen(gemcitabine 1000 mg/m^(2) plus nabpaclitaxel 125 mg/m^(2) on days 1, 8, and 15 every 4 wk) and 2 patients received the modified FOLFIRINOX regimen(intravenous oxaliplatin 68 mg/m^(2), irinotecan 135 mg/m^(2), and leucovorin 400 mg/m^(2) on day 1 and fluorouracil 400 mg/m^(2) on day 1, followed by 46-h continuous infusion of fluorouracil 2400 mg/m^(2)). After each treatment cycle, abdominal CT, tumor markers, and circulating tumor cell counts were reviewed to evaluate the treatment efficacy. All 15 patients achieved partial remission. The surgical procedures included laparoscopic pancreaticoduodenectomy(LPD, n = 8) and laparoscopic radical antegrade modular pancreatosplenectomy(L-RAMPS, n = 7). None of them were converted to a laparotomy. One patient with pancreatic head carcinoma was found to have portal vein involvement during the operation, and LPD combined with vascular resection and reconstruction was performed. The amount of blood loss and operation times of L-RAMPS vs LPD were 435.71 ± 32.37 m L vs 343.75 ± 145.01 m L and 272.52 ± 49.14 min vs 444.38 ± 68.63 min, respectively. The number of dissected lymph nodes was 16.87 ± 4.10, and 3 patients had positive lymph nodes. One patient developed grade B postoperative pancreatic fistula(POPF) after LRAMPS, and one patient experienced jaundice after LPD. None of the patients died after surgery. As of April 2022, progressive disease was noted in 4 patients, 2 patients had liver metastasis, and one had both liver metastasis and lymph node metastasis and died during the follow-up period.CONCLUSION Laparoscopic radical resection of PDAC after NACT is safe and effective if it is performed by a surgeon with rich experience in LPD and in a large center of pancreatic surgery. 展开更多
关键词 Pancreatic ductal adenocarcinoma Neoadjuvant chemotherapy Laparoscopic pancreaticoduodenectomy Laparoscopic radical antegrade modular pancreatosplenectomy COMPLICATIONS
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Renal failure and hepatitis following ingestion of raw grass carp gallbladder:A case report 被引量:1
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作者 Li-Na Zhou Shao-Shao Dong +1 位作者 Sheng-Ze Zhang wen huang 《World Journal of Clinical Cases》 SCIE 2021年第4期943-950,共8页
BACKGROUND Fish gallbladder has long been used as a folk remedy in Asian countries.Multiple organ damage after ingestion of fish gallbladder resulting in near mortality has been known to us.Here,we describe a case of ... BACKGROUND Fish gallbladder has long been used as a folk remedy in Asian countries.Multiple organ damage after ingestion of fish gallbladder resulting in near mortality has been known to us.Here,we describe a case of acute renal failure(ARF)and hepatitis due to grass carp gallbladder poisoning and review the literature.CASE SUMMARY A previously healthy,50-year-old woman was admitted to our hospital with a 2-d history of generalized abdominal pain and repeated vomiting following ingestion of two raw grass carp gallbladders in an attempt to alleviate her cough.She developed anuria on day 4 with markedly elevated serum creatinine,urea,bilirubin,alanine aminotransferase,and aspartate aminotransferase.Based on thorough evaluation of her history and prompt biochemical investigations,we diagnosed her with ARF and hepatitis secondary to fish gallbladder poisoning.Her renal biopsy revealed acute tubular necrosis,following which she underwent six sessions of conventional hemodialysis due to renal failure.Supportive treatment with gastric mucosal protectant and liver protectant was administered for targeted organ protection.The patient’s liver function gradually recovered,and serum creatinine was 164 mmol/L at discharge on day 24.Over a follow-up period of 2 wk,her renal function completely recovered.CONCLUSION Physicians should be mindful of toxic complications of raw grass carp gallbladder ingestion and we should promote awareness to reduce incidences of food poisoning. 展开更多
关键词 Grass carp gallbladder Case report Acute renal failure HEPATITIS Ichthyogallotoxin HEMODIALYSIS
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沙利度胺联合XELOX方案对晚期胃癌患者血清VEGF、ESM-1及NRP-1水平的影响 被引量:2
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作者 汪斐 刘佩 +1 位作者 黄雯 蒲嘉泽 《国际感染病学(电子版)》 CAS 2019年第4期5-6,共2页
目的探讨在晚期胃癌患者中联合应用沙利度胺及XELOX(卡培他滨+奥沙利铂)方案对血清血管内皮生长因子(VEGF)、内皮细胞特异性分子-1(ESM-1)及神经纤毛蛋白-1(NRP-1)水平的影响.方法选择2017年12月-2019年3月在我院进行治疗的晚期胃癌患... 目的探讨在晚期胃癌患者中联合应用沙利度胺及XELOX(卡培他滨+奥沙利铂)方案对血清血管内皮生长因子(VEGF)、内皮细胞特异性分子-1(ESM-1)及神经纤毛蛋白-1(NRP-1)水平的影响.方法选择2017年12月-2019年3月在我院进行治疗的晚期胃癌患者30例,随机分为2组,各15例.对照组实施XELOX方案,在此基础上,观察组加用沙利度胺片,比较两组血清NRP-1、ESM-1、VEGF及不良反应.结果治疗后,与对照组相比,观察组血清NRP-1、ESM-1及VEGF水平均较低,差异有统计学意义(P<0.05).两组不良反应发生率对比,差异无统计学意义(P>0.05).结论在晚期胃癌患者中联合应用沙利度胺及XELOX方案治疗,可有效降低血清VEGF、ESM-1及NRP-1水平,阻碍肿瘤新生血管形成,且安全性较高. 展开更多
关键词 晚期胃癌 沙利度胺片 卡培他滨片 注射用奥沙利铂 血管内皮生长因子 内皮细胞特异性分子-1 神经纤毛蛋白-1
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A review of some new perspectives on the theory of superconducting Sr_(2)RuO_(4)
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作者 wen huang 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第10期29-36,共8页
The nature of the Cooper pairing in the paradigmatic unconventional superconductor Sr_(2)RuO_(4) is an outstanding puzzle in condensed matter physics.Despite the tremendous efforts made in the past twenty-seven years,... The nature of the Cooper pairing in the paradigmatic unconventional superconductor Sr_(2)RuO_(4) is an outstanding puzzle in condensed matter physics.Despite the tremendous efforts made in the past twenty-seven years,neither the pairing symmetry nor the underlying pairing mechanism in this material has been understood with clear consensus.This is largely due to the lack of a superconducting order that is capable of interpreting in a coherent manner the numerous essential experimental observations.At this stage,it may be desirable to reexamine our existing theoretical descriptions of superconducting Sr_(2)RuO_(4).This review focuses on several recent developments that may provide some clues for future study.We highlight three separate aspects:1)any pairing in the Eu symmetry channel,with which the widely discussed chiral p-wave is associated,shall acquire a 3D structure due to spin-orbit entanglement;2)if the reported Kerr effect is a superconductivity-induced intrinsic bulk response,the superconductivity must either exhibit a chiral character,or be complex mixtures of certain set of helical p-wave pairings;3)when expressed in a multiorbital basis,the Cooper pairing could acquire numerous exotic forms that are inaccessible in single-orbital descriptions.The implications of each of these new perspectives are briefly discussed in connection with selected experimental phenomena. 展开更多
关键词 Sr_(2)RuO_(4) unconventional superconductivity pairing symmetry Kerr effect
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Familial gastrointestinal stromal tumors with KIT germline mutation in a Chinese family:A case report
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作者 Wei Yuan wen huang +9 位作者 Lei Ren Chen Xu Li-Juan Luan Jie huang An-Wei Xue Yong Fang Xiao-Dong Gao Kun-Tang Shen Jing-Huan Lv Ying-Yong Hou 《World Journal of Clinical Cases》 SCIE 2022年第15期4878-4885,共8页
BACKGROUND Familial gastrointestinal stromal tumors(GISTs)is a rare autosomal dominant disorder characterized by an array of clinical manifestations.Only 35 kindreds with germline KIT mutations and six with germline P... BACKGROUND Familial gastrointestinal stromal tumors(GISTs)is a rare autosomal dominant disorder characterized by an array of clinical manifestations.Only 35 kindreds with germline KIT mutations and six with germline PDGFRA mutations have been reported so far.It is often characterized by a series of manifestations,such as multiple lesions and hyperpigmentation.However,the effect of imatinib treatment in these patients is still uncertain.CASE SUMMARY Here,we report two patients(father and daughter)in a Chinese family(for the first time)with germline KIT mutation,and described their pathology,genetics and clinical manifestations.A 25-year-old Chinese woman went to hospital because of abdominal pain,and computed tomography showed multiple tumors in the small intestine.Small pigmented spots appeared on the skin within a few months after birth.Her father also had multiple pigmented spots and a history of multifocal GISTs.Multiple GISTs associated with diffuse interstitial Cajal cells(ICCs)hyperplasia were positive for CD117 and DOG-1.Gene sequencing revealed a germline mutation at codon 560 of exon 11(p.V560G)of KIT gene in these two patients.Imatinib therapy showed the long-lasting disease stability after resection.Remarkably,the hypopigmentation of the skin could also be observed.Luckily germline KIT mutation has not been identified yet in the 3-year-old daughter of the female patient.CONCLUSION Diagnosis of familial GISTs depends on combination of diffuse ICCs hyperplasia,germline KIT/PDGFRA mutation,hyperpigmentation and family history. 展开更多
关键词 Familial gastrointestinal stromal tumor Germline KIT mutation Cutaneous hyperpigmentation Imatinib therapy Case report
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Establish Albumin-creatinine Ratio Reference Value of Adults in the Rural Area of Hebei Province
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作者 Qiao-jing Liang wen huang +1 位作者 Guo-juan Zhang Ning-li Wang 《Chinese Medical Sciences Journal》 CAS CSCD 2016年第1期23-30,共8页
Objective To establish albumin-creatinine ratio (ACR) reference value of the rural population in Hebei province. Methods This study enrolled 5154 participants. By excluding subjects with hypertension, diabetes, dys... Objective To establish albumin-creatinine ratio (ACR) reference value of the rural population in Hebei province. Methods This study enrolled 5154 participants. By excluding subjects with hypertension, diabetes, dyslipidemia, cardiovascular and cerebrovascular diseases, kidney diseases, and overweight condition, as well as those with an estimated glomerular filtration rate (eGFR)(60 ml/(min· 1.73 m^2), apparently healthy subjects (1168) were selected. Urine albumin was measured by using the immunoturbidimetic method, serum creatinine was measured by using Jaffe's kinetic method on a morning spot-urine sample, and ACR was calculated. The 95th percentile of ACR in the healthy subjects was used as the normal upper limit. Results The normal upper limit of ACR was 28.71 mg/g (3.25 mg/retool) for males and 31.85 mg/g (3.60 rag/retool) for females. Based on this ACR reference value, the age-gender standardized prevalence of albuminuria in the rural areas of Hebei province was 12.9%. Conclusion The ACR reference value in the rural of Hebei province is higher than that of the Western population. 展开更多
关键词 albumin-creatinine ratio ALBUMINURIA chronic kidney disease
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Study on Distribution Coefficient of Traction Return Current in High-Speed Railway
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作者 wen huang Zhengyou He +2 位作者 Zhengyou He Haitao Hu Qi Wang 《Energy and Power Engineering》 2013年第4期1253-1258,共6页
The distribution coefficient of return current network is an important method to decrease the rail potential. In order to resolve the problem of high rail potential in high-speed railway based on EN50122-1 and Pr EN50... The distribution coefficient of return current network is an important method to decrease the rail potential. In order to resolve the problem of high rail potential in high-speed railway based on EN50122-1 and Pr EN50170 the distribution coefficient of longitudinal traction return current conductors is calculated through changing the interval of transverse connection. Based on field data and theoretical analysis, the parameters of longitudinal traction return current conductors are calculated. Results indicate that the best distance of the transverse connection is 400 m – 600 m. 展开更多
关键词 TRACTION RETURN CURRENT RAIL Potential Distribution Coefficient Interval of TRANSVERSE Connection
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Hot Spot Analysis and Development Trend of Intelligent Roof Parking Lot:Bibliometric Analysis Based on CiteSpace Visualization Software
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作者 wen huang Zenan CHEN Jianfeng XIE 《Asian Agricultural Research》 2021年第7期16-19,共4页
Using CiteSpace visualization software,literature research on roof parking lot in recent 20 years is analyzed,and the research direction and development of the relevant papers are integrated and induced.From utilizati... Using CiteSpace visualization software,literature research on roof parking lot in recent 20 years is analyzed,and the research direction and development of the relevant papers are integrated and induced.From utilization development,roof greening and technical practice,overall consideration and grasp of the feasibility of roof parking lot are conducted.Realization paths of two kinds of roof parking lots are provided:suspended PRT stereo parking lot and telescopic rail elevator,and it is committed to providing feasible suggestions and reference for future roof parking lot. 展开更多
关键词 CiteSpace visualization software Roof parking lot Lifting and lowering device
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