Optical coherence tomography(OCT)has been widely applied to the diagnosis of eye diseasesduring the past two decades.However,valid evaluation methods are stil not available for theclinical OCT devices.In order to asse...Optical coherence tomography(OCT)has been widely applied to the diagnosis of eye diseasesduring the past two decades.However,valid evaluation methods are stil not available for theclinical OCT devices.In order to assess the axial resolution of the OCT system,standard modeleyes with micro-scale multilayer structure have been designed and manufactured in this study.Mimicking a natural human eye,proper Titanium dioxide(TiO_(2))materials of particles withdifferent concentrations were selected by testing the scattering coefficient of PDMS phantoms.The artificial retinas with multilayer films were fabricated with the thicknesses from 9.5 to 30 micrometers using spin coating technology,Subsequently,standard OCT model eyes were ac-complished by embedding the retina phantoms into the artificial frames of eyes.For ease ofmeasurement processing,a series of model eyes were prepared,and each contained flms withthree kinds of thicknesses.Considering the traceability and accuracy of the key parameters of the standard model eyes,the thicknesses of multilayer structures were verfed using ThicknessMonitoring System.Through the experiment with three different OCT devices,it demonstratedthe model eyes fabricated in this study can provide an effective evaluation method for the axialresolution of an ophthalmic OCT device.展开更多
基金supported by the National Key Research and Development Program of China(2016YFF0201005).
文摘Optical coherence tomography(OCT)has been widely applied to the diagnosis of eye diseasesduring the past two decades.However,valid evaluation methods are stil not available for theclinical OCT devices.In order to assess the axial resolution of the OCT system,standard modeleyes with micro-scale multilayer structure have been designed and manufactured in this study.Mimicking a natural human eye,proper Titanium dioxide(TiO_(2))materials of particles withdifferent concentrations were selected by testing the scattering coefficient of PDMS phantoms.The artificial retinas with multilayer films were fabricated with the thicknesses from 9.5 to 30 micrometers using spin coating technology,Subsequently,standard OCT model eyes were ac-complished by embedding the retina phantoms into the artificial frames of eyes.For ease ofmeasurement processing,a series of model eyes were prepared,and each contained flms withthree kinds of thicknesses.Considering the traceability and accuracy of the key parameters of the standard model eyes,the thicknesses of multilayer structures were verfed using ThicknessMonitoring System.Through the experiment with three different OCT devices,it demonstratedthe model eyes fabricated in this study can provide an effective evaluation method for the axialresolution of an ophthalmic OCT device.
