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葛根素对犬膝骨关节炎的软骨保护和抗炎作用
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作者 阮红日 马天文 +7 位作者 赵菁华 王甜甜 郭颖超 王莹莹 赵冰儿 魏成威 温亚静 高利 《动物医学进展》 北大核心 2023年第7期38-44,共7页
骨关节炎(OA)引起的功能障碍是老年犬残疾的主要原因之一,旨在评估葛根素对前十字韧带切断(ACLT)诱导的犬OA模型中的抗炎和抗软骨降解作用。选取16只雄性德国牧羊犬,随机分为对照组、模型组、阳性对照组(200 mg/kg塞来昔布)、葛根素组(2... 骨关节炎(OA)引起的功能障碍是老年犬残疾的主要原因之一,旨在评估葛根素对前十字韧带切断(ACLT)诱导的犬OA模型中的抗炎和抗软骨降解作用。选取16只雄性德国牧羊犬,随机分为对照组、模型组、阳性对照组(200 mg/kg塞来昔布)、葛根素组(20 mg/kg),每组4只。对照组进行假手术,其他采用ACLT进行诱导OA模型,葛根素组和阳性对照组在造模2周后每天灌胃给药,干预至第8周。通过ELISA检测血清中IL-1β、IL-6、TNF-α、CTX-Ⅱ、COMP和CS 846,并在第8周时进行临床和影像学评估,综合评价葛根素对犬OA的保护作用。葛根素给药后能够显著抑制血清中IL-1β、IL-6和TNF-α的表达(P<0.05),其抗炎作用与口服塞来昔布相似,并且葛根素能够显著降低血清中骨代谢指标CTX-Ⅱ、COMP和CS 846的水平(P<0.05),在第8周时与模型组相比葛根素组临床评分和X线片评分均显著降低(P<0.05)。基于以上结果推测葛根素对犬OA模型的炎症反应有抑制作用,对软骨具有显著的保护作用。 展开更多
关键词 葛根素 骨关节炎 炎症因子 生物标志物 前十字韧带横断
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Effect of Xylazine Anesthesia on Glu and GABA Amino Acid Neurotransmitters in Rat 被引量:3
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作者 Zhang Xin-tong Li Li-na +6 位作者 Wang Qi Chang Tian wen ya-jing Yuan Rui Du Xue-man Tang Sai-nan Gao Li 《Journal of Northeast Agricultural University(English Edition)》 CAS 2019年第1期46-52,共7页
Neurotransmitters of the central nervous system were the important way to study the mechanism of anesthesia. The effect of different doses of xylazine anesthetic on the glutamate(Glu) and γ-aminobutyric-acid(GABA) we... Neurotransmitters of the central nervous system were the important way to study the mechanism of anesthesia. The effect of different doses of xylazine anesthetic on the glutamate(Glu) and γ-aminobutyric-acid(GABA) were investigated and the mechanism of xylazine anesthetic on the central nervous system were explored in this study. A total of 88 rats were randomly divided into three groups, including normal saline control group, group with low dose of xylazine and group with high dose of xylazine.Cerebrum, cerebellum, hippocampus, thalamus and brainstem were collected. The results showed that the concentration of Glu in the hippocampus, thalamus and brainstem decreased first and then increased, but it increased first and then decreased in the cerebrum and cerebellum during the period of anesthesia. The concentration of GABA in the cerebrum, thalamus, brainstem and hippocampus increased first and then decreased. The results showed that xylazine inhibited Glu and promoted GABA with different dose dependence. The results and methods could provide guides for the clinical use of xylazine. 展开更多
关键词 brain GLUTAMATE γ-aminobutyric acid RAT XYLAZINE
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