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碳纤维含量对碳纤维增强聚醚醚酮复合材料弯曲性能和失效行为的影响
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作者 何理 邹春龙 +1 位作者 文周 王红霞 《塑料工业》 CAS CSCD 北大核心 2024年第2期120-127,共8页
基于渐进损伤的VUMAT子程序,并引入了Johnson-Cook模型,通过Matlab生成了不同碳纤维占比的碳纤维增强聚醚醚酮(CFRP)复合材料,建立了三点弯曲有限元模型。通过分析应力—应变分布、载荷—位移曲线和吸收能—位移曲线得出以下结论:添加... 基于渐进损伤的VUMAT子程序,并引入了Johnson-Cook模型,通过Matlab生成了不同碳纤维占比的碳纤维增强聚醚醚酮(CFRP)复合材料,建立了三点弯曲有限元模型。通过分析应力—应变分布、载荷—位移曲线和吸收能—位移曲线得出以下结论:添加碳纤维有效改善了基体聚醚醚酮(PEEK)内部的应力—应变分布,显著提升了材料的力学性能、刚度和抗断裂性能。CFRP复合材料在三点弯曲过程中表现出更好的性能,能够承受明显的塑性变形,且有效避免裂纹扩展。此外,在相同位移载荷条件下,随着碳纤维含量增加,CFRP复合材料的位移逐渐减小。特别是在碳纤维质量分数为10%和20%的复合材料中,上表面和下表面的最大位移呈现出曲折的特点。结合应力—应变场的分布情况,这表明碳纤维的添加能有效提高材料的刚度和抗弯性能。 展开更多
关键词 碳纤维增强聚醚醚酮 三点弯曲 VUMAT子程序 Johnson-Cook模型 弯曲性能
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自噬在泌尿系常见肿瘤中的研究进展
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作者 向阳 文周 +4 位作者 杨萌 袁东波 吕涵 陈宗裕 朱建国 《中国医药》 2024年第9期1421-1425,共5页
自噬可以通过吞噬并降解细胞内的蛋白、细胞器以及其他胞质成分,实现细胞器的更新和满足自身的代谢需要。生理情况下,自噬有利于维持细胞的稳态,而自噬紊乱是多种泌尿系肿瘤发生发展的关键机制。自噬在肿瘤形成的早期作为其抑制因素,而... 自噬可以通过吞噬并降解细胞内的蛋白、细胞器以及其他胞质成分,实现细胞器的更新和满足自身的代谢需要。生理情况下,自噬有利于维持细胞的稳态,而自噬紊乱是多种泌尿系肿瘤发生发展的关键机制。自噬在肿瘤形成的早期作为其抑制因素,而晚期为癌细胞提供营养物质促进生长。目前大量研究表明,细胞自噬在泌尿系肿瘤的发生发展中发挥重要作用,同时自噬对肿瘤治疗有细胞保护性和细胞毒性的双重影响,因此通过调控自噬能提高其治愈率,为泌尿系肿瘤提供新的治疗方向。本文主要总结了自噬的发生机制以及对泌尿系肿瘤发生发展的作用和潜在的治疗价值,致力于将自噬调节和现有的泌尿系肿瘤治疗方式结合有助于增加抗肿瘤治疗效果。 展开更多
关键词 泌尿系肿瘤 自噬 耐药性 前列腺癌 肾癌 膀胱癌
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蛇莓提取物通过GPX4诱导铁死亡抑制肾癌细胞OS-RC-2增殖
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作者 游赣花 安群英 +5 位作者 何娟 李凯 杨萌 文周 钱城 朱建国 《中国药理学通报》 CAS CSCD 北大核心 2024年第4期662-670,共9页
目的探讨蛇莓醇提物通过铁死亡抑制肾癌细胞OS-RC-2增殖的作用机制。方法蛇莓醇提物给药,CCK-8试验检测细胞增殖;活性氧(reactive oxygen species,ROS)检测试剂盒、GSH试剂盒、MDA试剂盒、细胞凋亡试剂盒分别检测细胞ROS、GSH、MDA含量... 目的探讨蛇莓醇提物通过铁死亡抑制肾癌细胞OS-RC-2增殖的作用机制。方法蛇莓醇提物给药,CCK-8试验检测细胞增殖;活性氧(reactive oxygen species,ROS)检测试剂盒、GSH试剂盒、MDA试剂盒、细胞凋亡试剂盒分别检测细胞ROS、GSH、MDA含量及凋亡水平;网络药理学分析蛇莓成分-靶点;分子对接检测蛇莓成分与铁死亡核心靶点GPX4的结合能力;Western blot对铁死亡信号通路关键蛋白进行检测;利用铁死亡的抑制剂Fer-1和ROS抑制剂NAC进行回复试验,检测细胞增殖及铁死亡蛋白的变化;蛇莓醇提物中的Dulcitol(卫矛醇)给药,检测细胞增殖及GPX4蛋白的变化。结果蛇莓可在一定程度上呈时间-浓度依赖性抑制细胞增殖,显著增加ROS、MDA水平而降低GSH水平;流式细胞术显示蛇莓可显著促进细胞凋亡,但并没有呈浓度依赖方式;网络药理学和分子对接结果显示蛇莓中的卫矛醇与GPX4结合稳定(-6.5 kJ·mol^(-1));Western blot结果显示蛇莓明显降低GPX4、SLC7A11并升高HO-1及Transferrin蛋白水平;回复试验结果显示,Fer-1与蛇莓联合给药、NAC与蛇莓联合给药均可显著逆转蛇莓单独给药引起的细胞活力降低和铁死亡关键蛋白GPX4、SLC7A11、HO-1及Transferrin的蛋白水平变化。卫矛醇给药可抑制OS-RC-2细胞增殖并降低GPX4蛋白表达水平。结论综上所述,蛇莓醇提物可能通过降低GPX4的表达,促使肾癌细胞发生增殖抑制及ROS积累,进一步驱动细胞铁死亡,且卫矛醇可能是蛇莓中潜在的直接作用于GPX4的药效物质。 展开更多
关键词 蛇莓 卫矛醇 OS-RC-2细胞 谷胱甘肽过氧化物酶4 活性氧 铁死亡
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Westerlies Affecting the Seasonal Variation of Water Vapor Transport over the Tibetan Plateau Induced by Tropical Cyclones in the Bay of Bengal
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作者 Xiaoli zhou wen zhou +3 位作者 Dongxiao WANG Qiang XIE Lei YANG Qihua PENG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第5期881-893,共13页
This study investigates the activity of tropical cyclones(TCs)in the Bay of Bengal(BOB)from 1979 to 2018 to discover the mechanism affecting the contribution rate to the meridional moisture budget anomaly(MMBA)over th... This study investigates the activity of tropical cyclones(TCs)in the Bay of Bengal(BOB)from 1979 to 2018 to discover the mechanism affecting the contribution rate to the meridional moisture budget anomaly(MMBA)over the southern boundary of the Tibetan Plateau(SBTP).May and October–December are the bimodal phases of BOB TC frequency,which decreases month by month from October to December and is relatively low in May.However,the contribution rate to the MMBA is the highest in May.The seasonal variation in the meridional position of the westerlies is the key factor affecting the contribution rate.The relatively southern(northern)position of the westerlies in November and December(May)results in a lower(higher)contribution rate to the MMBA.This mechanism is confirmed by the momentum equation.When water vapor enters the westerlies near the trough line,the resultant meridional acceleration is directed north.It follows that the farther north the trough is,and the farther north the water vapor can be transported.When water vapor enters the westerlies from the area near the ridge line,for Type-T(Type-R)TCs,water vapor enters the westerlies downstream of the trough(ridge).Consequently,the direction of the resultant meridional acceleration is directed south and the resultant zonal acceleration is directed east(west),which is not conducive to the northward transport of water vapor.This is especially the case if the trough or ridge is relatively south,as the water vapor may not cross the SBTP. 展开更多
关键词 tropical cyclone Tibetan Plateau Bay of Bengal moisture budget weste
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Fabrication and integration of photonic devices for phase-change memory and neuromorphic computing
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作者 wen zhou Xueyang Shen +2 位作者 Xiaolong Yang Jiangjing Wang Wei Zhang 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2024年第2期2-27,共26页
In the past decade,there has been tremendous progress in integrating chalcogenide phase-change materials(PCMs)on the silicon photonic platform for non-volatile memory to neuromorphic in-memory computing applications.I... In the past decade,there has been tremendous progress in integrating chalcogenide phase-change materials(PCMs)on the silicon photonic platform for non-volatile memory to neuromorphic in-memory computing applications.In particular,these non von Neumann computational elements and systems benefit from mass manufacturing of silicon photonic integrated circuits(PICs)on 8-inch wafers using a 130 nm complementary metal-oxide semiconductor line.Chip manufacturing based on deep-ultraviolet lithography and electron-beam lithography enables rapid prototyping of PICs,which can be integrated with high-quality PCMs based on the wafer-scale sputtering technique as a back-end-of-line process.In this article,we present an overview of recent advances in waveguide integrated PCM memory cells,functional devices,and neuromorphic systems,with an emphasis on fabrication and integration processes to attain state-of-the-art device performance.After a short overview of PCM based photonic devices,we discuss the materials properties of the functional layer as well as the progress on the light guiding layer,namely,the silicon and germanium waveguide platforms.Next,we discuss the cleanroom fabrication flow of waveguide devices integrated with thin films and nanowires,silicon waveguides and plasmonic microheaters for the electrothermal switching of PCMs and mixed-mode operation.Finally,the fabrication of photonic and photonic–electronic neuromorphic computing systems is reviewed.These systems consist of arrays of PCM memory elements for associative learning,matrix-vector multiplication,and pattern recognition.With large-scale integration,the neuromorphic photonic computing paradigm holds the promise to outperform digital electronic accelerators by taking the advantages of ultra-high bandwidth,high speed,and energy-efficient operation in running machine learning algorithms. 展开更多
关键词 nanofabrication silicon photonics phase-change materials non-volatile photonic memory neuromorphic photonic computing
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Decadal Changes in Dry and Wet Heatwaves in Eastern China:Spatial Patterns and Risk Assessment
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作者 Yue ZHANG wen zhou Ruhua ZHANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第10期2011-2026,共16页
Under global warming,understanding the long-term variation in different types of heatwaves is vital for China’s preparedness against escalating heat stress.This study investigates dry and wet heatwave shifts in easte... Under global warming,understanding the long-term variation in different types of heatwaves is vital for China’s preparedness against escalating heat stress.This study investigates dry and wet heatwave shifts in eastern China over recent decades.Spatial trend analysis displays pronounced warming in inland midlatitudes and the Yangtze River Valley,with increased humidity in coastal regions.EOF results indicate intensifying dry heatwaves in northern China,while the Yangtze River Valley sees more frequent dry heatwaves.On the other hand,Indochina and regions north of 25°N also experience intensified wet heatwaves,corresponding to regional humidity increases.Composite analysis is conducted based on different situations:strong,frequent dry or wet heatwaves.Strong dry heatwaves are influenced by anticyclonic circulations over northern China,accompanied by warming SST anomalies around the coastal midlatitudes of the western North Pacific(WNP).Frequent dry heatwaves are related to strong subsidence along with a strengthened subtropical high over the WNP.Strong and frequent wet heatwaves show an intensified Okhotsk high at higher latitudes in the lower troposphere,and a negative circumglobal teleconnection wave train pattern in the upper troposphere.Decaying El Niño SST patterns are observed in two kinds of wet heatwave and frequent dry heatwave years.Risk analysis indicates that El Niño events heighten the likelihood of these heatwaves in regions most at risk.As global warming continues,adapting and implementing mitigation strategies toward extreme heatwaves becomes crucial,especially for the aforementioned regions under significant heat stress. 展开更多
关键词 decadal changes dry heatwave wet heatwave eastern China
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Experimental Analysis of Radial Centrifugal Pump Shutdown
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作者 Xiao Sun Jiangbo Tong +4 位作者 Yuliang Zhang Haibing Cai wen zhou Xiaoqi Jia Litao Ou 《Fluid Dynamics & Materials Processing》 EI 2024年第4期725-737,共13页
Centrifugal pumps are widely used in the metallurgy,coal,and building sectors.In order to study the hydraulic characteristics of a closed impeller centrifugal pump during its shutdown in the so-called power frequency ... Centrifugal pumps are widely used in the metallurgy,coal,and building sectors.In order to study the hydraulic characteristics of a closed impeller centrifugal pump during its shutdown in the so-called power frequency and frequency conversion modes,experiments were carried to determine the characteristic evolution of parameters such as speed,inlet and outlet pressure,head,flow rate and shaft power.A quasi-steady-state method was also used to further investigate these transient behaviors.The results show that,compared to the power frequency input,the performance parameter curves for the frequency conversion input are less volatile and smoother.The characteristic time is longer and the response to shutdown is slower.The quasi-steady-state theoretical head-flow curves match the experimental head-flow curves more closely at low flow rates when the frequency conversion input is considered.Moreover,in this case,the similarity law predicts the hydraulic performance more accurately. 展开更多
关键词 Centrifugal pump power frequency frequency conversion SHUTDOWN external characteristic experimental study
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Progress and future prospects of decadal prediction and data assimilation:A review
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作者 wen zhou Jinxiao Li +5 位作者 Zixiang Yan Zili Shen Bo Wu Bin Wang Ronghua Zhang Zhijin Li 《Atmospheric and Oceanic Science Letters》 CSCD 2024年第1期53-62,共10页
年代际预测,也称为“近期气候预测”,旨在预测未来1-10年内的气候变化,是气候预测和气候变化研究领域的一个新关注点.它位于季节至年际预测和长期气候变化预测之间,结合了初值问题和外部强迫问题的两个方面.年代际预测的核心技术在于用... 年代际预测,也称为“近期气候预测”,旨在预测未来1-10年内的气候变化,是气候预测和气候变化研究领域的一个新关注点.它位于季节至年际预测和长期气候变化预测之间,结合了初值问题和外部强迫问题的两个方面.年代际预测的核心技术在于用于模式初始化的同化方法的准确性和效率,其目标是为模式提供准确的初始条件,其中包含观测到的气候系统内部变率,年代际预测的初始化通常涉及在耦合框架内同化海洋观测,其中观测到的信号通过耦合过程传递到其他分量,如大气和海冰.然而,最近的研究越来越关注在海洋-大气耦合模式中探索耦合数据同化(CDA),有人认为CDA有潜力显著提高年代际预测技巧.本文综合评述了该领域的三个方面的研究现状:初始化方法,年代际气候预测的可预测性和预测技巧,以及年代际预测的未来发展和挑战. 展开更多
关键词 年代际预测 四维数据同化 海气相互作用
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八角莲醇提物抑制MAPK信号通路引起肾癌细胞凋亡的作用机制 被引量:1
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作者 游赣花 何恋 +4 位作者 李凯 杨萌 文周 刘旺培 朱建国 《中国药理学通报》 CAS CSCD 北大核心 2023年第12期2305-2313,共9页
目的探讨八角莲醇提物对肾透明细胞癌OS-RC-2细胞增殖、凋亡的影响及作用机制。方法八角莲给药,CCK-8及克隆形成实验检测给药后OS-RC-2细胞增殖情况;划痕实验及Transwell实验检测细胞迁移情况;活性氧(Reactive oxygen species,ROS)检测... 目的探讨八角莲醇提物对肾透明细胞癌OS-RC-2细胞增殖、凋亡的影响及作用机制。方法八角莲给药,CCK-8及克隆形成实验检测给药后OS-RC-2细胞增殖情况;划痕实验及Transwell实验检测细胞迁移情况;活性氧(Reactive oxygen species,ROS)检测试剂盒检测细胞ROS水平。网络药理学进行八角莲及ROS共同靶点的获取,并进行KEGG分析。流式细胞仪检测细胞凋亡及周期水平,Western blot对MAPK信号通路关键蛋白及凋亡相关蛋白进行检测。结果八角莲可明显抑制OS-RC-2细胞增殖、迁移能力,并升高细胞ROS水平。网络药理学分析显示,共得到165个八角莲-ROS的共同靶点,KEGG分析发现,MAPK信号通路变化明显。Western blot结果显示,八角莲给药后,明显降低JNK蛋白水平及p-ERK/ERK比值;降低caspase-9及Bcl-2蛋白水平,而升高cleaved caspase-9及Bax蛋白表达。流式结果显示,八角莲给药可促进细胞凋亡,降低G 1期而升高G 2/M期细胞量。回复实验结果显示,ROS抑制剂NAC与八角莲联合给药可明显逆转八角莲单独给药对OS-RC-2的细胞活力及凋亡作用,以及对细胞凋亡关键蛋白、MAPK信号通路蛋白的表达改变。结论八角莲可能通过影响ROS水平发挥MAPK信号通路抑制作用,并进一步对OS-RC-2细胞产生促凋亡及抑制增殖作用。 展开更多
关键词 八角莲 肾癌 OS-RC-2细胞 活性氧 MAPK信号通路 凋亡
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云南特色植物资源在化妆品中的研究与应用 被引量:1
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作者 孙晓曼 孟宪瑶 +3 位作者 周雯 郭苗苗 凌霄 李丽 《日用化学工业(中英文)》 CAS 北大核心 2023年第12期1459-1465,共7页
基于植物提取物的安全性及功效性,植物资源已被广泛应用于医药、食品、农业等领域,中草药等特色植物的开发是我国植物化妆品的独特优势。据《2021年云南省生态环境状况公报》显示,云南有已知高等植物19333种(占全国50.1%),其中中国特有... 基于植物提取物的安全性及功效性,植物资源已被广泛应用于医药、食品、农业等领域,中草药等特色植物的开发是我国植物化妆品的独特优势。据《2021年云南省生态环境状况公报》显示,云南有已知高等植物19333种(占全国50.1%),其中中国特有高等植物8772种,211种植物为云南地区特有或仅在云南地区分布。近年来,云南特色植物在化妆品功效原料筛选、有效成分提取、功效验证等研究上均取得成效,成为未来化妆品市场发展的重要趋势。文章从云南16市州的地貌特点以及云南地区特色植物资源的区域分布、生长季节和产量概况出发,首次系统分析粗茎秦艽(Gentiana crassicaulis)、赤桉(Eucalyptus camaldulensis)、云南重楼(Paris polyphylla var.yunnanensis)、铁皮石斛(Dendrobium officinale)等22种云南特色植物资源在祛痘、保湿、美白、抗皱紧致等功效化妆品中的应用现状及前景,为云南特色植物作为化妆品功效原料的研究和应用提供理论支持。 展开更多
关键词 化妆品功效原料 云南特色植物资源 区域分布 化妆品应用
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3D DBSCAN detection and parameter sensitivity of the 2022 Yangtze river summertime heatwave and drought 被引量:5
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作者 Zhenchen Liu wen zhou Yuan Yuan 《Atmospheric and Oceanic Science Letters》 CSCD 2023年第4期15-21,共7页
极端气候事件的精准识别是机理分析的重要前提.本研究借助无监督机器学习中经典的DBSCAN密度聚类算法,发展了在三维(经度-纬度-时间)空间内进行目标事件识别和参数敏感性分析的研究方案.在2022年长江全域高温伏秋旱事件识别中的应用表明... 极端气候事件的精准识别是机理分析的重要前提.本研究借助无监督机器学习中经典的DBSCAN密度聚类算法,发展了在三维(经度-纬度-时间)空间内进行目标事件识别和参数敏感性分析的研究方案.在2022年长江全域高温伏秋旱事件识别中的应用表明,本次天气尺度极端热浪和季节尺度重旱事件的产生发展,空间传播模式不同.天气尺度热浪信号自6月底从北太平洋向西南方向延伸,直至8月中旬覆盖长江全域;季节重旱信号于7月中旬从孟加拉湾陆面区域向东北向延伸,直至9月中旬覆盖长江全域.同时,本研究中亦进行了相关参数敏感性的详细分析,对算法应用,结果理解亦有帮助. 展开更多
关键词 DBSCAN算法 复合气候极值事件 高温干旱 长江流域 机器学习
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Construction of fault diagnosis system for control rod drive mechanism based on knowledge graph and Bayesian inference 被引量:3
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作者 Xue‑Jun Jiang wen zhou Jie Hou 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2023年第2期58-75,共18页
Knowledge graph technology has distinct advantages in terms of fault diagnosis.In this study,the control rod drive mechanism(CRDM)of the liquid fuel thorium molten salt reactor(TMSR-LF1)was taken as the research objec... Knowledge graph technology has distinct advantages in terms of fault diagnosis.In this study,the control rod drive mechanism(CRDM)of the liquid fuel thorium molten salt reactor(TMSR-LF1)was taken as the research object,and a fault diagnosis system was proposed based on knowledge graph.The subject–relation–object triples are defined based on CRDM unstructured data,including design specification,operation and maintenance manual,alarm list,and other forms of expert experience.In this study,we constructed a fault event ontology model to label the entity and relationship involved in the corpus of CRDM fault events.A three-layer robustly optimized bidirectional encoder representation from transformers(RBT3)pre-training approach combined with a text convolutional neural network(TextCNN)was introduced to facilitate the application of the constructed CRDM fault diagnosis graph database for fault query.The RBT3-TextCNN model along with the Jieba tool is proposed for extracting entities and recognizing the fault query intent simultaneously.Experiments on the dataset collected from TMSR-LF1 CRDM fault diagnosis unstructured data demonstrate that this model has the potential to improve the effect of intent recognition and entity extraction.Additionally,a fault alarm monitoring module was developed based on WebSocket protocol to deliver detailed information about the appeared fault to the operator automatically.Furthermore,the Bayesian inference method combined with the variable elimination algorithm was proposed to enable the development of a relatively intelligent and reliable fault diagnosis system.Finally,a CRDM fault diagnosis Web interface integrated with graph data visualization was constructed,making the CRDM fault diagnosis process intuitive and effective. 展开更多
关键词 CRDM Knowledge graph Fault diagnosis Bayesian inference RBT3-TextCNN Web interface
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352-Gbit/s single line rate THz wired transmission based on PS-4096QAM employing hollow-core fiber 被引量:4
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作者 Junjie Ding Yuxuan Tan +8 位作者 Yanyi Wang Jiao Zhang Menghui He Feng Zhao Li Zhao wen zhou Yiwei Shi Min Zhu Jianjun Yu 《Digital Communications and Networks》 SCIE CSCD 2023年第3期717-722,共6页
We successfully demonstrate 32-Gbaud Probabilistically Shaped 4096-ary Quadrature Amplitude Modulation(PS-4096QAM)TeraHertz(THz)signal wired transmission at 325 GHz over the 1-m Hollow-Core Fiber(HCF)in a photon-assis... We successfully demonstrate 32-Gbaud Probabilistically Shaped 4096-ary Quadrature Amplitude Modulation(PS-4096QAM)TeraHertz(THz)signal wired transmission at 325 GHz over the 1-m Hollow-Core Fiber(HCF)in a photon-assisted THz-wave communication system.By employing advanced Digital Signal Processing(DSP)and the PS technique,the 352-Gbit/s line rate(288-Gbit/s net rate)delivery with a net Spectral Efficiency(SE)of 9 bit/s/Hz is realized in the experiment,satisfying the 0.86-Normalized Generalized Mutual Information(NGMI)Low-Density Parity-Check(LDPC)threshold. 展开更多
关键词 Hollow-core fiber Terahertz-wave communication Photonics-aided scheme Probabilistic shaping
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黑龙江孙吴江段岸滩防护治理数学模型计算分析
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作者 于宁 黄海 +1 位作者 温州 关见朝 《泥沙研究》 CAS CSCD 北大核心 2023年第1期33-40,共8页
黑龙江孙吴江段受水流剧烈冲刷严重危害沿岸安全。通过构建孙吴江段三维非结构网格水流泥沙数值模型,研究不同频率洪水条件下,孙吴江段岸滩防护工程对水力特性的影响,预测江段冲淤演变趋势及其防护前后的变化。研究结果表明,防护工程对... 黑龙江孙吴江段受水流剧烈冲刷严重危害沿岸安全。通过构建孙吴江段三维非结构网格水流泥沙数值模型,研究不同频率洪水条件下,孙吴江段岸滩防护工程对水力特性的影响,预测江段冲淤演变趋势及其防护前后的变化。研究结果表明,防护工程对孙吴江段水位与流速的影响随着洪水流量的增加而减小,二十年一遇洪水条件下,防护工程附近区域水位抬升普遍不超过2 cm,主河道内流速变化不超过0.1 m/s。修建防护工程后,孙吴江段内的中方滩、岛边岸受到保护的位置稳定性更好,综合治理技术发挥了明显的防护作用。 展开更多
关键词 黑龙江 孙吴江段 水沙数学模型 河床冲淤演变
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Curcumin alleviated dextran sulfate sodium-induced colitis by recovering memory Th/Tfh subset balance 被引量:1
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作者 Lin-Xin Zheng Kai-En Guo +7 位作者 Jia-Qi Huang Miao-Hua Liu Bai-Ling Deng Duan-Yong Liu Bu-Gao zhou wen zhou You-Bao Zhong Hai-Mei Zhao 《World Journal of Gastroenterology》 SCIE CAS 2023年第36期5226-5239,共14页
BACKGROUND Restoration of immune homeostasis by targeting the balance between memory T helper(mTh)cells and memory follicular T helper(mTfh)cells is a potential therapeutic strategy against ulcerative colitis(UC).Beca... BACKGROUND Restoration of immune homeostasis by targeting the balance between memory T helper(mTh)cells and memory follicular T helper(mTfh)cells is a potential therapeutic strategy against ulcerative colitis(UC).Because of its anti-inflammatory and immunomodulatory properties,curcumin(Cur)is a promising drug for UC treatment.However,fewer studies have demonstrated whether Cur can modulate the mTh/mTfh subset balance in mice with colitis.AIM To explore the potential mechanism underlying Cur-mediated alleviation of colitis induced by dextran sulfate sodium(DSS)in mice by regulating the mTh and mTfh immune homeostasis.METHODS Balb/c mice were administered 3%and 2%DSS to establish the UC model and treated with Cur(200 mg/kg/d)by gavage on days 11-17.On the 18th d,all mice were anesthetized and euthanized,and the colonic length,colonic weight,and colonic weight index were evaluated.Histomorphological changes in the mouse colon were observed through hematoxylin-eosin staining.Levels of Th/mTh and Tfh/mTfh cell subsets in the spleen were detected through flow cytometry.Western blotting was performed to detect SOCS-1,SOCS-3,STAT3,p-STAT3,JAK1,p-JAK1,and NF-κB p65 protein expression levels in colon tissues.RESULTS Cur effectively mitigates DSS-induced colitis,facilitates the restoration of mouse weight and colonic length,and diminishes the colonic weight and colonic weight index.Simultaneously,it hinders ulcer development and inflammatory cell infiltration in the colonic mucous membrane.While the percentage of Th1,mTh1,Th7,mTh7,Th17,mTh17,Tfh1,mTfh1,Tfh7,mTfh7,Tfh17,and mTfh17 cells decreased after Cur treatment of the mice for 7 d,and the frequency of mTh10,Th10,mTfh10,and Tfh10 cells in the mouse spleen increased.Further studies revealed that Cur administration prominently decreased the SOCS-1,SOCS-3,STAT3,p-STAT3,JAK1,p-JAK1,and NF-κB p65 protein expression levels in the colon tissue.CONCLUSION Cur regulated the mTh/mTfh cell homeostasis to reduce DSS-induced colonic pathological damage,potentially by suppressing the JAK1/STAT3/SOCS signaling pathway. 展开更多
关键词 CURCUMIN Ulcerative colitis Memory T helper Memory follicular T helper JAK1/STAT3/SOCS
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Observed decadal shifts and trends in global tropical cyclone activities from 1980 to 2021 被引量:1
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作者 Widana Arachchige Erandani Lakshani wen zhou 《Atmospheric and Oceanic Science Letters》 CSCD 2023年第2期35-41,共7页
研究发现在1980-2021期间全球6个海域每年热带气旋的发生频次和强度具有显著年代际变化规律,最近几十年,北大西洋和北印度洋的热带气旋发生频次明显增加,但西北太平洋的热带气旋却显著下降.另外三个海域,东太平洋,南印度洋和南太平洋发... 研究发现在1980-2021期间全球6个海域每年热带气旋的发生频次和强度具有显著年代际变化规律,最近几十年,北大西洋和北印度洋的热带气旋发生频次明显增加,但西北太平洋的热带气旋却显著下降.另外三个海域,东太平洋,南印度洋和南太平洋发现所生成的热带气旋有减少趋势.但在过去十几年,平均热带气旋的强度除了在东太平洋和北大西洋有所减弱但在其他几个海域有所加强,特别是在2013-2021期间,北印度洋的平均热带气旋的强度增强明显.热带气旋的潜在生成指数(GPI)增加或减少趋势变化与北印度洋,北大西洋和西太平洋热带气旋变化相关的大尺度环流一致.另外,北印度洋,北大西洋和西太平洋上空的垂直风切变是影响其区域热带气旋发生频次变化的主要因子,不同的气候模态也可能对全球热带气旋的趋势变化和年代际变化有影响,值得进一步研究. 展开更多
关键词 热带气旋 热带气旋强度 潜在生成指数 大尺度参数
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Analysis of the Characteristics of the Low-level Jets in the Middle Reaches of the Yangtze River during the Mei-yu Season
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作者 Chunguang CUI wen zhou +5 位作者 Hao YANG Xiaokang WANG Yi DENG Xiaofang WANG Guirong XU Jingyu WANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第4期711-724,共14页
Here,we analyze the characteristics and the formation mechanisms of low-level jets(LLJs)in the middle reaches of the Yangtze River during the 2010 mei-yu season using Wuhan station radiosonde data and the fifth genera... Here,we analyze the characteristics and the formation mechanisms of low-level jets(LLJs)in the middle reaches of the Yangtze River during the 2010 mei-yu season using Wuhan station radiosonde data and the fifth generation of the European Centre for Medium-Range Weather Forecasts(ERA5)reanalysis dataset.Our results show that the vertical structure of LLJs is characterized by a predominance of boundary layer jets(BLJs)concentrated at heights of 900-1200 m.The BLJs occur most frequently at 2300 LST(LST=UTC+8 hours)but are strongest at 0200 LST,with composite wind velocities>14 m s^(-1).Synoptic-system-related LLJs(SLLJs)occur most frequently at 0800 LST but are strongest at 1100LST,with composite wind velocities>12 m s^(-1).Both BLJs and SLLJs are characterized by a southwesterly wind direction,although the wind direction of SLLJs is more westerly,and northeasterly SLLJs occur more frequently than northeasterly BLJs.When Wuhan is south of the mei-yu front,the westward extension of the northwest Pacific subtropical high intensifies,and the low-pressure system in the eastern Tibetan Plateau strengthens,favoring the formation of LLJs,which are closely related to precipitation.The wind speeds on rainstorm days are greater than those on LLJ days.Our analysis of four typical heavy precipitation events shows the presence of LLJs at the center of the precipitation and on its southern side before the onset of heavy precipitation.BLJs were shown to develop earlier than SLLJs. 展开更多
关键词 mei-yu front boundary layer jets synoptic low-level jets heavy rainfall middle reaches of the Yangtze River
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Impact of Saharan dust on landfalling North Atlantic tropical cyclones over North America in September
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作者 Zhenxi Zhang wen zhou 《Atmospheric and Oceanic Science Letters》 CSCD 2023年第1期22-26,共5页
本项研究利用再分析数据和模式模拟数据分析了沙尘的气溶胶光学厚度与台风的登陆,轨迹,强度及相关气象环境参数的关系,揭示了9月北大西洋台风的登陆次数会在撒哈拉沙尘较强的年份中增加,以及这一现象的物理机制,撒哈拉沙尘对热带北大西... 本项研究利用再分析数据和模式模拟数据分析了沙尘的气溶胶光学厚度与台风的登陆,轨迹,强度及相关气象环境参数的关系,揭示了9月北大西洋台风的登陆次数会在撒哈拉沙尘较强的年份中增加,以及这一现象的物理机制,撒哈拉沙尘对热带北大西洋中部海表温度具有抑制作用,会阻碍该地区的台风活动,因此台风只能向西移动进入海表温度较高的热带北大西洋西部,从而更易于形成强台风,这一物理过程将导致台风登陆北美大陆的频次增加,特别是强台风登陆美国的可能性增强,产生更大的潜在破坏性. 展开更多
关键词 台风 登陆 潜在强度理论 沙尘颗粒物 海表温度
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Extended Impact of Cold Air Invasions in East Asia in Response to a Warm South China Sea and Philippine Sea
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作者 Marco Y.-T.LEUNG Dongxiao WANG +1 位作者 wen zhou Yuntao JIAN 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第3期531-540,共10页
During boreal winter,the invasion of cold air can lead to remarkable temperature drops in East Asia which can result in serious socioeconomic impacts.Here,we find that the intensity of strong synoptic cold days in the... During boreal winter,the invasion of cold air can lead to remarkable temperature drops in East Asia which can result in serious socioeconomic impacts.Here,we find that the intensity of strong synoptic cold days in the East China Sea and Indochina Peninsula are increasing.The enhanced synoptic cold days in these two regions are attributed to surface warming over the South China Sea and Philippine Sea(SCSPS).The oceanic forcing of the SCSPS on the synoptic cold days in the two regions is verified by numerical simulation.The warming of the SCSPS enhances the baroclinicity,which intensifies meridional wind and cold advection on synoptic timescales.This leads to a more extended region that is subject to the influence of cold invasion. 展开更多
关键词 ocean warming extra-tropical cyclones BAROCLINICITY temperature whiplash
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Impact of Southern Indian ocean dipole via the ITCZ on winter and spring precipitation in China
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作者 Ran Dong Yuanhong Guan +1 位作者 wen zhou Chenguang Guo 《Atmospheric and Oceanic Science Letters》 CSCD 2023年第6期28-33,共6页
本文分析了1979-2021年南印度洋冬季海表面温度特征,印度洋热带辐合带(ITCZ)位置变化及其对中国冬春季降水的影响.EOF分析第一模态表明南印度洋冬季海表面温度异常显示西南-东北反相分布,即南印度洋偶极子模态(SIOD).分离厄尔尼诺-南方... 本文分析了1979-2021年南印度洋冬季海表面温度特征,印度洋热带辐合带(ITCZ)位置变化及其对中国冬春季降水的影响.EOF分析第一模态表明南印度洋冬季海表面温度异常显示西南-东北反相分布,即南印度洋偶极子模态(SIOD).分离厄尔尼诺-南方涛动(ENSO)信号后,纯SIOD事件对同年冬季和次年春季的印度洋ITCZ位置(35°-75°E平均)均有影响,冬季,纯正(负)SIOD事件使印度洋ITCZ往南(北)移动.春季,SIOD则使印度洋ITCZ移动方向与冬季相反,且移动幅度更大.冬,春季长江中下游地区(MLYR)的降水量与印度洋ITCZ位置分别呈正,负相关.同时,在纯正(负)SIOD事件下,冬,春季MLYR的降水分别减少,增加,可见印度洋ITCZ位置变化可能是SIOD影响MLYR冬,春季降水的媒介之一. 展开更多
关键词 南印度洋偶极子 ENSO ITCZ 降水
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