The mechanical performance and a rate-dependent constitutive model for Al3Ti compound

The Al3Ti compound has potential application in the high temperature structure materials due to its low density,high strength and stiffness.The mechanical behaviors of the material under different loading rates were studied using compression tests.The results indicate that Al3Ti is a typical brittle material and its compressive strength is dependent on the strain rate.Therefore,a series of rate-dependent constitutive equations are needed to describe its mechanical behaviors accurately.However,it is still short of professional research on the material model for Al3Ti.In this study,the mate rial model was developed on the basis of JH-2 constitutive equations using the experimental data.The model was then applied in simulating the impact process of Ti/Al3Ti metal-intermetallic laminate composites so as to validate the established model.Good agreement between simulation and experiment results shows the constitutive model predict the material responses under high rate and large deformation accurately.This work provides more support for the theoretical and numerical research on the intermetallic.

Exact Entanglement Dynamics in Three Interacting Qubits

Motivated by recent experimental studies on coherent dynamics transfer in three interacting atoms or electron spins [Phys. Rev. Lett 114（2015） 113002, Phys. Rev. Lett 120（2018） 243604], here we study entanglement entropy transfer in three interacting qubits. We analytically calculate time evolutions of wave function, density matrix and entanglement of the system. We find that initially entangled two qubits may alternatively transfer their entanglement entropy to other two qubit pairs. Thus dynamical evolution of three interacting qubits may produce a genuine three-partite entangled state through entanglement entropy transfers. In particular, different pairwise interactions of the three qubits endow symmetric and asymmetric evolutions of the entanglement transfer,characterized by the quantum mutual information and concurrence. Finally, we discuss an experimental proposal of three Rydberg atoms for testing the entanglement dynamics transfer of this kind.

Progress of Alzheimer＇s disease related glucose metabolism regulating hormones and a research perspective in nootropics of herbal medicine

阿尔茨海默病是一种神经退行性疾病,但其发病机制尚不清楚.有证据表明糖尿病与阿尔茨海默病发病有关,而糖尿病发病的的根本原因是糖代谢异常.因此糖代谢调节激素和阿尔茨海默病之间可能存在不可分离的关系.作者综述了糖代谢调节激素与阿尔茨海默病发病机制的相关研究进展,并基于此对益智中药研究提出了新思路.

Protocol for evaluating the effects of Danggui Shaoyao Powder in the treatment of DPN with qi deficiency and blood stasis pattern based on routine therapy:a randomized controlled trial

Background:Diabetic peripheral neuropathy(DPN)has high incidence.At present,the treatment for DPN mainly focuses on controlling of blood sugar,nourishment of nerves and symptomatic treatment of pain which face some limitations,such as poor effects and adverse reactions of drugs and so on.Traditional Chinese Medicine(TCM)has certain curative effect in the prevention and treatment of DPN.Danggui Shaoyao powder,one of the famous classic prescriptions in TCM,has been often used clinically in the treatment of DPN in China,which without any relevant evidence-based medical research data.The protocol was designed to evaluate the effects of Danggui Shaoyao Powder in the treatment of DPN with qi deficiency and blood stasis pattern based on routine therapy.Methods:This protocol is designed as a three-arms parallel-group,outcome-assessor blinded RCT.303 Patients with DPN,from outpatient and inpatient departments of four clinical centers in China,will be randomly allocated into 3 groups(routine group,treatment group and control group).The course of treatment was designed as 1 month and followed up for 3 months.The TCSS scale,TCM syndrome scale,nerve conduction function,serum indexes will be tested to provide more clinical evidences for the effect of Danggui Shaoyao Powder on prevention and treatment of DPN.Finally,we will make statistics and analyse the data to draw a conclusion.Discussion:Danggui Shaoyao Powder is the ideal drug which is an agent acting on multiple targets related to DPN’s pathogenesis.We hope to find more clinical evidences for the effect of Danggui Shaoyao Powder on prevention and treatment of DPN through this RCT experiment.

A novel loss-of-function variant in PNLDC1 inducing oligo-astheno-teratozoospermia and male infertility

Male infertility is a major reproductive disorder,which is clinically characterized by highly heterogeneous phenotypes of abnormal sperm count or quality.To date,five male patients with biallelic loss-of-function(LOF)variants of PARN-like ribonuclease domain-containing exonuclease 1(PNLDC1)have been reported to experience infertility with nonobstructive azoospermia.The aim of this study was to identify the genetic cause of male infertility with oligo-astheno-teratozoospermia(OAT)in a patient from a Chinese Han family.Whole-exome and Sanger sequencing analyses identified a homozygous LOF variant(NM_173516.2,c.l42C>T,p.Gln48Ter)in PNLDC1.Hematoxylin and eosin staining revealed that the spermatozoa of the patient with OAT had an irregular head phenotype,including microcephaly,head tapering,and globozoospermia.Consistently,peanut agglutinin staining of the spermatozoa revealed a complete or partial loss of the acrosome.Furthermore,the disomy rate of chromosomes in the patient’s spermatozoa was significantly increased compared with that of a fertile control sample.We reported an LOF variant of the PNLDC1 gene responsible for OAT.

Broadside Compensation Rolling Model for Plan View Pattern Control in Wide and Heavy Plate Rolling Process

On the basis of a 5 m plate mill, a 3D rigid-plastic finite element （FE） model was developed to investigate changes of plate plan view patterns during hot rolling process. By analyzing the simulation results of conventional rolling processes, it was found that the plate plan view pattern was closely related to broadside rolling ratio. Then, the prediction models for plate plan view patterns were formulated by nonlinear regressive analysis of the simulation results and modified for high accuracy. Based on these models, the broadside compensation rolling method perform- ing at the last pass of broadside rolling phase was designed to decrease plate end crops. Comparing the plate plan view patterns with and without broadside compensation roiling, reduced plate end crops indicate that the broadside compensation roiling model is effective for plate plan view pattern control.

A recurrent mutation in TBPL2 causes diminished ovarian reserve and female infertility

Diminished ovarian reserve(DOR)is a disorder of ovarian function in which the ovary loses its normal reproductive potential,including decreasing oocyte quantity and quality.The disorder is associated with infertility in women of reproductive age with regular menses and poor response to controlled ovarian hyperstimulation(Broekmans et al.,2009).

Quantum dynamics of Gaudin magnets

Quantum dynamics of many-body systems is a fascinating and significant subject for both theory and experiment.The question of how an isolated many-body system evolves to its steady state after a sudden perturbation or quench still remains challenging.In this paper,using the Bethe ansatz wave function,we study the quantum dynamics of an inhomogeneous Gaudin magnet.We derive explicit analytical expressions for various local dynamic quantities with an arbitrary number of flipped bath spins,such as:the spin distribution function,the spin-spin correlation function,and the Loschmidt echo.We also numerically study the relaxation behavior of these dynamic properties,gaining considerable insight into coherence and entanglement between the central spin and the bath.In particular,we find that the spin-spin correlations relax to their steady value via a nearly logarithmic scaling,whereas the Loschmidt echo shows an exponential relaxation to its steady value.Our results advance the understanding of relaxation dynamics and quantum correlations of long-range interacting models of the Gaudin type.