AIM: To identify the predictive factors and laser photocoagulation associated with the use of silicone oil as endotamponade during primary diabetic vitrectomy. METHODS: The medical and surgical records of 690 patients...AIM: To identify the predictive factors and laser photocoagulation associated with the use of silicone oil as endotamponade during primary diabetic vitrectomy. METHODS: The medical and surgical records of 690 patients(798 eyes) who underwent primary diabetic vitrectomy at a tertiary eye hospital in China from January 2018 to December 2018 were reviewed in this retrospective cohort study. The patients’ baseline characteristics and preoperative treatments were recorded. The binary Logistic regression model was used to evaluate the risk factors for the use of silicone oil as endotamponade agent during primary vitrectomy for proliferative diabetic retinopathy(PDR)-related complications.RESULTS: Among 690 patients with mean age of 52.1±10.5 y(range: 18-85 y), 299/690(43.3%) were female. The 31.6% of the eyes received preoperative laser treatment, and 72.4% of the eyes received preoperative anti-VEGF adjuvant therapy. Non-clearing vitreous haemorrhage(VH) alone or combined with retinal detachment was the main surgical indication(89.5%) for primary vitrectomy. Silicone oil was used as endotamponade in 313(39.2%) eyes. Lack of preoperative laser treatment [odds ratio(OR) 0.66, 95% confidence interval(CI): 0.48-0.92;P=0.015] and older age(OR 0.96, 95%CI: 0.95-0.98;P<0.001) were predictors of silicone oil tamponade during primary vitrectomy for PDR. CONCLUSION: The lack of preoperative laser treatment is a significant predictor of silicone oil tamponade during primary vitrectomy for PDR. However, the severity of PDR relevant to silicone oil use should be further evaluated.展开更多
Background:Toxocariasis is a neglected parasitic zoonosis that afflicts millions of the pediatric and adolescent populations worldwide,especially in impoverished communities.This disease is caused by infection with th...Background:Toxocariasis is a neglected parasitic zoonosis that afflicts millions of the pediatric and adolescent populations worldwide,especially in impoverished communities.This disease is caused by infection with the larvae of Toxocara canis and T.cati,the most ubiquitous intestinal nematode parasite in dogs and cats,respectively.In this article,recent advances in the epidemiology,clinical presentation,diagnosis and pharmacotherapies that have been used in the treatment of toxocariasis are reviewed.Main text:Over the past two decades,we have come far in our understanding of the biology and epidemiology of toxocariasis.However,lack of laboratory infrastructure in some countries,lack of uniform case definitions and limited surveillance infrastructure are some of the challenges that hindered the estimation of global disease burden.Toxocariasis encompasses four clinical forms:visceral,ocular,covert and neural.Incorrect or misdiagnosis of any of these disabling conditions can result in severe health consequences and considerable medical care spending.Fortunately,multiple diagnostic modalities are available,which if effectively used together with the administration of appropriate pharmacologic therapies,can minimize any unnecessary patient morbidity.Conclusions:Although progress has been made in the management of toxocariasis patients,there remains much work to be done.Implementation of new technologies and better understanding of the pathogenesis of toxocariasis can identify new diagnostic biomarkers,which may help in increasing diagnostic accuracy.Also,further clinical research breakthroughs are needed to develop better ways to effectively control and prevent this serious disease.展开更多
To the Editor： Calcific discitis is a self-limiting cervical disc disease usually seen in children and uncommon in adults.[1] It can typically be cured by conservative treatment.[2] In this article, we reported a cas...To the Editor： Calcific discitis is a self-limiting cervical disc disease usually seen in children and uncommon in adults.[1] It can typically be cured by conservative treatment.[2] In this article, we reported a case of paralysis caused by thoracolumbar calcific discitis, with acute herniation.展开更多
The drying shrinkage of geopolymers poses significant limitations on their potential as constructive materials.In this study,the drying shrinkage of metakaolin-based geopolymer(MKG)with different initial water/solid r...The drying shrinkage of geopolymers poses significant limitations on their potential as constructive materials.In this study,the drying shrinkage of metakaolin-based geopolymer(MKG)with different initial water/solid ratios and pore structures was investigated experimentally.According to mini-bar shrinkage experiments,the drying shrinkage-water loss relation of MKG showed two-stage behavior.The initial water/solid ratio influences the critical water loss and span of the pausing period of the shrinkage curves but not the general trend.Combined with the microstructure characterization and physical estimation,the underlying dependency of the shrinkage on the pore structure of the binder was elucidated.Capillary pressure,surface energy change,and gel densification dominate the drying shrinkage of MKG at different water loss stages.The findings indicate that besides porosity control,finer tuning of the pore size distribution is needed to control the drying shrinkage of MKG.展开更多
基金Supported by the National Natural Science Foundation of China(No.82070972)the Natural Science Foundation of Guangdong Province(No.2019A1515011347)+1 种基金the grants from the Guangdong Province High-level Hospital Construction Program(No.303020103)the Key Science&Technology Project of Guangzhou(No.202103000045)。
文摘AIM: To identify the predictive factors and laser photocoagulation associated with the use of silicone oil as endotamponade during primary diabetic vitrectomy. METHODS: The medical and surgical records of 690 patients(798 eyes) who underwent primary diabetic vitrectomy at a tertiary eye hospital in China from January 2018 to December 2018 were reviewed in this retrospective cohort study. The patients’ baseline characteristics and preoperative treatments were recorded. The binary Logistic regression model was used to evaluate the risk factors for the use of silicone oil as endotamponade agent during primary vitrectomy for proliferative diabetic retinopathy(PDR)-related complications.RESULTS: Among 690 patients with mean age of 52.1±10.5 y(range: 18-85 y), 299/690(43.3%) were female. The 31.6% of the eyes received preoperative laser treatment, and 72.4% of the eyes received preoperative anti-VEGF adjuvant therapy. Non-clearing vitreous haemorrhage(VH) alone or combined with retinal detachment was the main surgical indication(89.5%) for primary vitrectomy. Silicone oil was used as endotamponade in 313(39.2%) eyes. Lack of preoperative laser treatment [odds ratio(OR) 0.66, 95% confidence interval(CI): 0.48-0.92;P=0.015] and older age(OR 0.96, 95%CI: 0.95-0.98;P<0.001) were predictors of silicone oil tamponade during primary vitrectomy for PDR. CONCLUSION: The lack of preoperative laser treatment is a significant predictor of silicone oil tamponade during primary vitrectomy for PDR. However, the severity of PDR relevant to silicone oil use should be further evaluated.
基金This study was financially supported by the Elite Program of Chinese Academy of Agricultural Sciences,the International Science&Technology Cooperation Program of China(grant No.2013DFA31840)the Agricultural Science and Technology Innovation Program(ASTIP)(Grant No.CAAS-ASTIP-2016-LVRI-03).
文摘Background:Toxocariasis is a neglected parasitic zoonosis that afflicts millions of the pediatric and adolescent populations worldwide,especially in impoverished communities.This disease is caused by infection with the larvae of Toxocara canis and T.cati,the most ubiquitous intestinal nematode parasite in dogs and cats,respectively.In this article,recent advances in the epidemiology,clinical presentation,diagnosis and pharmacotherapies that have been used in the treatment of toxocariasis are reviewed.Main text:Over the past two decades,we have come far in our understanding of the biology and epidemiology of toxocariasis.However,lack of laboratory infrastructure in some countries,lack of uniform case definitions and limited surveillance infrastructure are some of the challenges that hindered the estimation of global disease burden.Toxocariasis encompasses four clinical forms:visceral,ocular,covert and neural.Incorrect or misdiagnosis of any of these disabling conditions can result in severe health consequences and considerable medical care spending.Fortunately,multiple diagnostic modalities are available,which if effectively used together with the administration of appropriate pharmacologic therapies,can minimize any unnecessary patient morbidity.Conclusions:Although progress has been made in the management of toxocariasis patients,there remains much work to be done.Implementation of new technologies and better understanding of the pathogenesis of toxocariasis can identify new diagnostic biomarkers,which may help in increasing diagnostic accuracy.Also,further clinical research breakthroughs are needed to develop better ways to effectively control and prevent this serious disease.
文摘To the Editor： Calcific discitis is a self-limiting cervical disc disease usually seen in children and uncommon in adults.[1] It can typically be cured by conservative treatment.[2] In this article, we reported a case of paralysis caused by thoracolumbar calcific discitis, with acute herniation.
基金Project supported by the National Key R&D Program of China(No.2018YFB0605700)and the National Natural Science Foundation of China(Nos.51879230 and 51778570)。
文摘The drying shrinkage of geopolymers poses significant limitations on their potential as constructive materials.In this study,the drying shrinkage of metakaolin-based geopolymer(MKG)with different initial water/solid ratios and pore structures was investigated experimentally.According to mini-bar shrinkage experiments,the drying shrinkage-water loss relation of MKG showed two-stage behavior.The initial water/solid ratio influences the critical water loss and span of the pausing period of the shrinkage curves but not the general trend.Combined with the microstructure characterization and physical estimation,the underlying dependency of the shrinkage on the pore structure of the binder was elucidated.Capillary pressure,surface energy change,and gel densification dominate the drying shrinkage of MKG at different water loss stages.The findings indicate that besides porosity control,finer tuning of the pore size distribution is needed to control the drying shrinkage of MKG.
