Clinical efficacy of radiofrequency ablation for primary hepatocellular carcinoma

Objective:To summarize and analyze the effects of radiofrequency ablation (RFA) on patients' condition and quality of life after treatment of large liver cancer.Methods: A total of 51 patients with primary liver cancer with a diameter of 4-7 cm were selected from our hospital. The related tumor markers and liver function indexes were analyzed before and after treatment, and the patients' progression-free survival was analyzed with long-term follow-up.Results: On the 3rd day after the treatment, the AFP level of the patients was not significantly different from that before the treatment (P>0.05), and on the 7th day after the treatment, the AFP level was significantly lower than that before the treatment (P<0.05). The levels of CA199 and ferritin were slightly higher on the 3rd day after treatment than before treatment (P<0.05), and the levels of CA199 and ferritin were significantly lower on the 7th day after treatment than before treatment (P<0.05). The index of liver function at 3 days after treatment was slightly higher than that before treatment (P<0.05), and there was no significant difference in liver function at 7 d after treatment (P>0.05). Progression-free survival was observed at 1 month (90.2%), 38 at 3 months (74.5%), 33 at 6 months (64.7%), and 28 at 12 months (54.9%). After 1 month of treatment, the ECOG of 48 patients recovered to the pre-treatment level, with 3 cases of deterioration (including 2 deaths);After 3 months of treatment, there was no significant change in ECOG in 42 patients, and the ECOG score deteriorated in 9 patients (including 3 deaths). After 6 months of treatment, 36 cases of ECOG were unchanged, while 12 cases were deteriorated (including 5 deaths). After 12 months of treatment, 30 cases of ECOG were unchanged, with 21 cases of deterioration (including 9 deaths).Conclusion: Radiofrequency ablation can better alleviate the disease and improve the quality of life of patients with primary liver cancer with diameter of 4-7 cm. Further studies are needed to compare the effects of other local treatments.

Effect of corrosion on mechanical behaviors of Mg-Zn-Zr alloy in simulated body fluid

The main purpose of this paper is to investigate the effect of corrosion on mechanical behaviors of the Mg-Zn-Zr alloy immersed in simulated body fluid （SBF） with different immersion times. The corrosion behavior of the materials in SBF was determined by immersion tests. The surfaces of the corroded alloys were examined by SEM. The tensile samples of the extruded Mg-2Zn-0.8Zr magnesium alloy were immersed in the SBF for 0, 4, 7, 10, 14, 21 and 28 d. The tensile mechanical behaviors of test samples were performed on an electronic tensile testing machine. SEM was used to observe the fracture morphology. It was found that with extension of the immersion time, the ultimate tensile strength （UTS）, yield strength （YS） and elongation （EL） of the Mg-2Zn-0.8Zr samples decreased rapidly at first and then decreased slowly. The main fracture mechanism of the alloy transformed from ductile fracture to cleavage fracture with the increasing immersion times, which can be attributed to stress concentration and embrittlement caused by pit corrosion.