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Goal-Oriented Control Systems(GOCS):From HOW to WHAT
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作者 wen-hua chen 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第4期816-819,共4页
Brief:New control theory is required to underpin safe design and deployment of future highly automated systems to deal with uncertain environments and complicated tasks,enabled by AI and other advanced technologies.Go... Brief:New control theory is required to underpin safe design and deployment of future highly automated systems to deal with uncertain environments and complicated tasks,enabled by AI and other advanced technologies.Goal-Oriented Control Systems offer potential to transform the control system design from currently instructing a control system how to perform a task to specifying what is to be achieved. 展开更多
关键词 AUTOMATED instru SYSTEM
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Grinding Chatter Detection and Identication Based on BEMD and LSSVM 被引量:5
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作者 Huan-Guo chen Jian-Yang Shen +3 位作者 wen-hua chen Chun-Shao Huang Yong-Yu Yi Jia-cheng Qian 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2019年第1期90-102,共13页
Grinding chatter is a self?induced vibration which is unfavorable to precision machining processes. This paper proposes a forecasting method for grinding state identification based on bivarition empirical mode decompo... Grinding chatter is a self?induced vibration which is unfavorable to precision machining processes. This paper proposes a forecasting method for grinding state identification based on bivarition empirical mode decomposition(BEMD) and least squares support vector machine(LSSVM), which allows the monitoring of grinding chatter over time. BEMD is a promising technique in signal processing research which involves the decomposition of two?dimen?sional signals into a series of bivarition intrinsic mode functions(BIMFs). BEMD and the extraction criterion of its true BIMFs are investigated by processing a complex?value simulation chatter signal. Then the feature vectors which are employed as an amplification for the chatter premonition are discussed. Furthermore, the methodology is tested and validated by experimental data collected from a CNC guideway grinder KD4020 X16 in Hangzhou Hangji Machine Tool Co., Ltd. The results illustrate that the BEMD is a superior method in terms of processing non?stationary and nonlinear signals. Meanwhile, the peak to peak, real?time standard deviation and instantaneous energy are proven to be e ec?tive feature vectors which reflect the di erent grinding states. Finally, a LSSVM model is established for grinding status classification based on feature vectors, giving a prediction accuracy rate of 96%. 展开更多
关键词 GRINDING chatter BEMD and LSSVM Complex-value chatter signal FEATURE VECTOR GRINDING STATUS classification
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Model Predictive Control of Nonlinear Systems: Stability Region and Feasible Initial Control 被引量:5
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作者 Xiao-Bing Hu wen-hua chen 《International Journal of Automation and computing》 EI 2007年第2期195-202,共8页
这篇论文建议一个新方法为为非线性的系统的预兆的控制(MPC ) 建模计算稳定性区域和可行起始的控制侧面 / 顺序,它对 MPC 的实现重要。与许多存在方法不同,这篇论文把稳定性区域与保守终端区域区分开来。与全球 linearization ,线性... 这篇论文建议一个新方法为为非线性的系统的预兆的控制(MPC ) 建模计算稳定性区域和可行起始的控制侧面 / 顺序,它对 MPC 的实现重要。与许多存在方法不同,这篇论文把稳定性区域与保守终端区域区分开来。与全球 linearization ,线性微分包括( LDI )和线性矩阵不平等( LMI )技术,一个非线性的系统被转变成集合的线性系统,然后顶点的一个凸的集合被使用对离线设计控制器到估计稳定性区域,并且也侧面/顺序决定可行起始的控制。建议方法的优点被模拟学习表明。关键词为预兆的控制(MPC ) 建模 - 稳定性区域 - 终端区域 - 线性微分包括(LDI )- 线性矩阵不平等(LMI ) 这个工作被学生们授于胡到 Xiao 的海外研究支持。Xiao 胡收到了他的 B.Sc。在航空的度在中国的民用的航空研究所的电子设计,天津,中国在 1998, M.Sc。在在航空学与航天学的南京大学设计的自动控制的度,南京,中国在 2001,并且在在 Loughborough 大学的航空、汽车的工程的博士学位,英国,在 2005。他当前是在在萨西克斯郡大学的信息科学的部门的一个研究家伙,英国。他的研究兴趣包括预兆的控制,人工智能,空中交通管理,和飞行控制。陈文华收到了他的 M。Sc 和 Ph。D。从在东北大学的自动控制的部门的学位,中国在 1989 和 1991,分别地。从 1991 ~ 1996,他是在在航空学与航天学的南京大学的自动控制的部门的一个讲师,中国。他在格拉斯哥大学在在系统的中心设计的控制和控制担任了研究职务然后一个讲师,英国,从 1997 ~ 2000。他在 Loughborough 大学在航空、汽车的工程的部门在飞行控制系统保持一个高级讲师,英国。他在杂志和会议上出版了一本书和超过 80 篇论文。他的研究兴趣在太空工程包括先进控制策略和他们的应用程序的开发。 展开更多
关键词 非线性系统 模型预测控制 稳定区 可行性初始控制
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Design of Accelerated Life Test Plans——Overview and Prospect 被引量:2
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作者 wen-hua chen Liang Gao +2 位作者 Jun Pan Ping Qian Qing-Chuan He 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2018年第1期19-33,共15页
Accelerated life test(ALT) is currently the main method of assessing product reliability rapidly, and the design of efficient test plans is a critical step to ensure that ALTs can assess the product reliability accura... Accelerated life test(ALT) is currently the main method of assessing product reliability rapidly, and the design of efficient test plans is a critical step to ensure that ALTs can assess the product reliability accurately, quickly, and economically. With the promotion of the national strategy of civil-military integration, ALT will be widely used in the research and development(R&D) of various types of products, and the ALT plan design theory will face further challenges. To aid engineers in selecting appropriate theories and to stimulate researchers to develop the theories required in engineering, with focus on the demands for theory research that arise from the implementation of ALT, this paper reviews and summarizes the development of ALT plan design theory. The development of the theory and method for planning optimal ALT for location-scale distribution, which is the most applied and mature theory of designing the optimal ALT plan, are described in detail. Taking this as the center of radiation, some problems that ALT now faces, such as the verification of the statistical model, limitation of sample size, solutions of resource limits, optimization of the test arrangement, and management of product complexity, are discussed, and the general ideas and methods of solving these problems are analyzed. Suggestions for selecting appropriate ALT plan design theories are proposed, and the urgent solved theory problems and opinions of their solutions are proposed. Based on the principle of convenience for engineers to select appropriate methods according to the problems found in practice, this paper reviews the development of optimal ALT plan design theory by taking the engineering problems arising from the ALT implementation as the main thread, provides guidelines on selecting appropriate theories for engineers, and proposes opinions about the urgent solved theory problems for researchers. 展开更多
关键词 Accelerated life test Test plan Optimal design Reliability assessment
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Octreotide-induced acute life-threatening gallstones after vicarious contrast medium excretion:A case report 被引量:2
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作者 Zong-Hong Han Zhong-Ming He +2 位作者 wen-hua chen Cao-Ye Wang Qi Wang 《World Journal of Clinical Cases》 SCIE 2021年第25期7484-7489,共6页
BACKGROUND Octreotide is widely used for the treatment of acromegaly,neuroendocrine tumors,and secretory diarrhea.However,long-term octreotide treatment can increase the incidence of gallstones.Vicarious contrast medi... BACKGROUND Octreotide is widely used for the treatment of acromegaly,neuroendocrine tumors,and secretory diarrhea.However,long-term octreotide treatment can increase the incidence of gallstones.Vicarious contrast medium excretion(VCME)through the hepatobiliary system is well known.However,few studies have reported octreotide-induced acute gallstones following VCME.CASE SUMMARY A 69-year-old man presented with left lower back pain and hematuria caused by a fall.The patient had a history of polycystic kidney disease.VCME occurred following renal artery embolization for a ruptured polycystic kidney.After 5 d of treatment with octreotide,the patient developed acute gallstones and intrahepatic cholestasis which further induced pancreatitis and cholangitis.He was discharged after hemodialysis,antibiotics,and supportive treatments.CONCLUSION For patients with a high-risk of VCME,octreotide should be cautiously administered and carefully monitored. 展开更多
关键词 OCTREOTIDE GALLSTONES Contrast medium Case report
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A Modified Model Predictive Control Scheme 被引量:1
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作者 Xiao-Bing Hu wen-hua chen 《International Journal of Automation and computing》 EI 2005年第1期101-106,共6页
In implementations of MPC (Model Predictive Control) schemes, two issues need to be addressed. One is how to enlarge the stability region as much as possible. The other is how to guarantee stability when a computation... In implementations of MPC (Model Predictive Control) schemes, two issues need to be addressed. One is how to enlarge the stability region as much as possible. The other is how to guarantee stability when a computational time limitation exists. In this paper, a modified MPC scheme for constrained linear systems is described. An o?ine LMI-based iteration process is introduced to expand the stability region. At the same time, a database of feasible control sequences is generated o?ine so that stability can still be guaranteed in the case of computational time limitations. Simulation results illustrate the e?ectiveness of this new approach. 展开更多
关键词 Model PREDICTIVE control linear matrix INEQUALITY stability REGION TERMINAL REGION feasibility.
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Composite Nonlinear Bilateral Control for Teleoperation Systems With External Disturbances 被引量:1
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作者 Zhenhua Zhao Jun Yang +1 位作者 Shihua Li wen-hua chen 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2019年第5期1220-1229,共10页
This paper presents a new composite nonlinear bilateral control method based on the nonlinear disturbance observer(NDOB) for teleoperation systems with external disturbances. By introducing the estimations of NDOB and... This paper presents a new composite nonlinear bilateral control method based on the nonlinear disturbance observer(NDOB) for teleoperation systems with external disturbances. By introducing the estimations of NDOB and systems' nominal nonlinear dynamics into controller design, a NDOB based composite nonlinear bilateral controller is constructed to attenuate the influence of disturbance and uncertain nonlinearities. As compared with the existing bilateral control methods which usually achieve force haptic(i.e., contact force tracking)through a passive way, the newly proposed method has two major merits: 1) asymptotical convergence of both position and force tracking errors is guaranteed;2) disturbance influence on force tracking error dynamics is rejected through the direct feedforward compensation of disturbance estimation. Simulations on a nonlinear teleoperation system are carried out and the results validate the effectiveness of the proposed controller. 展开更多
关键词 BILATERAL control DISTURBANCE OBSERVER FORCE HAPTIC TELEOPERATION
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Novel Accelerating Life Test Method and Its Application by Combining Constan Stress and Progressive Stress 被引量:1
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作者 wen-hua chen Fan Yang +2 位作者 Ping Qian Jun Pan Qing-Chuan He 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2018年第5期17-24,共8页
Constant stress accelerated life tests(ALTs) can be applied to obtain a high estimation accuracy of reliability measure?ments, but these are time?consuming tests. Progressive stress ALTs can yield failures more quickl... Constant stress accelerated life tests(ALTs) can be applied to obtain a high estimation accuracy of reliability measure?ments, but these are time?consuming tests. Progressive stress ALTs can yield failures more quickly but cannot guaran tee the estimation accuracy of reliability measurements. In this paper, a progressive?constant combination stress ALT is proposed to combine the merits of both tests. The optimal plan, in which the design variables are the initial pro?gressive stress level, the progressive stress ramp rate, the sample allocation proportion of the progressive stress and the constant stress level, is determined using the principle of minimizing the asymptotic variance of the maximum likelihood estimator of the natural log reliable life for the connectors. A comparison between the optimal PCCSALT plan and the CSALT plan with the same sample size and estimation accuracy shows that the test time is reduced by 13.59% by applying the PCCSALT. 展开更多
关键词 Constant stress Progressive stress Accelerated life test Optimal test plan Reliability test
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Process development for producing a food-grade glucose solution from rice straws
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作者 Chih-Heng Wang wen-hua chen +3 位作者 Hwai-Shen Liu Jinn-Tsyy Lai cheng-Che Hsu Ben-Zu Wan 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2018年第2期386-392,共7页
In this paper, processes for producing a food-grade glucose solution through enzymatic hydrolysis of celluloserich solids obtained from rice straws are presented. The rice straws were pretreated by acid-catalyzed stea... In this paper, processes for producing a food-grade glucose solution through enzymatic hydrolysis of celluloserich solids obtained from rice straws are presented. The rice straws were pretreated by acid-catalyzed steam explosion, and the reaction efficiency, toxicity control, and process economic feasibility were studied. Mass transfer resistance to the hydrolysis reaction was reduced by grinding with glass beads. A higher glucose concentration could be obtained by feeding more cellulose in the hydrolysis reaction; however, this also resulted in the production of undesired byproducts. Thus, a soaking process for the cellulose solids in water was developed to effectively reduce the generation of byproducts in the hydrolysis reaction. The resulting food-grade glucose solution can provide 414 kilocalories per liter, and could be used during a food-shortage crisis in the future.The current production cost is estimated to be 0.82 USD·L^(-1). 展开更多
关键词 生产费用 葡萄糖 食物 稻草 米饭 开发 水解作用 经济可行性
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Experimental Tests of Autonomous Ground Vehicles with Preview
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作者 Cunjia Liu wen-hua chen John Andrews 《International Journal of Automation and computing》 EI 2010年第3期342-348,共7页
This paper describes the design and experimental tests of a path planning and reference tracking algorithm for autonomous ground vehicles. The ground vehicles under consideration are equipped with forward looking sens... This paper describes the design and experimental tests of a path planning and reference tracking algorithm for autonomous ground vehicles. The ground vehicles under consideration are equipped with forward looking sensors that provide a preview capability over a certain horizon. A two-level control framework is proposed for real-time implementation of the model predictive control (MPC) algorithm, where the high-level performs on-line optimization to generate the best possible local reference respect to various constraints and the low-level commands the vehicle to follow realistic trajectories generated by the high-level controller. The proposed control scheme is implemented on an indoor testbed through networks with satisfactory performance. 展开更多
关键词 地面车辆 预览功能 试验测试 模型预测控制 跟踪算法 实验测试 路径规划 控制框架
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Robust Assignment of Airport Gates with Operational Safety Constraints 被引量:8
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作者 Shuo Liu wen-hua chen Jiyin Liu 《International Journal of Automation and computing》 EI CSCD 2016年第1期31-41,共11页
This paper reviews existing approaches to the airport gate assignment problem(AGAP) and presents an optimization model for the problem considering operational safety constraints. The main objective is to minimize the ... This paper reviews existing approaches to the airport gate assignment problem(AGAP) and presents an optimization model for the problem considering operational safety constraints. The main objective is to minimize the dispersion of gate idle time periods(to get robust optimization) while ensuring appropriate matching between the size of each aircraft and its assigned gate type and avoiding the potential hazard caused by gate apron operational conflict. Genetic algorithm is adopted to solve the problem. An illustrative example is given to show the effectiveness and efficiency of the algorithm. The algorithm performance is further demonstrated using data of a terminal from Beijing Capital International Airport(PEK). 展开更多
关键词 首都国际机场 安全约束 分配问题 鲁棒优化 操作 遗传算法 优化模型 分散体
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Potential Bands of Sentinel-2A Satellite for Classification Problems in Precision Agriculture 被引量:7
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作者 Tian-Xiang Zhang Jin-Ya Su +1 位作者 Cun-Jia Liu wen-hua chen 《International Journal of Automation and computing》 EI CSCD 2019年第1期16-26,共11页
Various indices are used for assessing vegetation and soil properties in satellite remote sensing applications. Some indices,such as normalized difference vegetation index(NDVI) and normalized difference water index(N... Various indices are used for assessing vegetation and soil properties in satellite remote sensing applications. Some indices,such as normalized difference vegetation index(NDVI) and normalized difference water index(NDWI), are capable of simply differentiating crop vitality and water stress. Nowadays, remote sensing capabilities with high spectral, spatial and temporal resolution are available to analyse classification problems in precision agriculture. Many challenges in precision agriculture can be addressed by supervised classification, such as crop type classification, disease and stress(e.g., grass, water and nitrogen) monitoring. Instead of performing classification based on designated indices, this paper explores direct classification using different bands information as features. Land cover classification by using the recently launched Sentinel-2A image is adopted as a case study to validate our method. Four approaches of featured band selection are compared to classify five classes(crop, tree, soil, water and road) with the support vector machines(SVMs)algorithm, where the first approach utilizes traditional empirical indices as features and the latter three approaches adopt specific bands(red, near infrared and short wave infrared) related to indices, specific bands after ranking by mutual information(MI), and full bands of on-board sensors as features, respectively. It is shown that a better classification performance can be achieved by directly using the selected bands after MI ranking compared with the one using empirical indices and specific bands related to indices, while the use of all 13 bands can marginally improve the classification accuracy than MI based one. Therefore, it is recommended that this approach can be applied for specific Sentinel-2A image classification problems in precision agriculture. 展开更多
关键词 Sentinel-2A REMOTE sensing image classification supervised learning PRECISION AGRICULTURE
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Energy-efficient power amplifiers and linearization techniques for massive MIMO transmitters: a review 被引量:2
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作者 Xin LIU Guan-sheng LV +2 位作者 De-han WANG wen-hua chen Fadhel MGHANNOUCHI 《Frontiers of Information Technology & Electronic Engineering》 SCIE EI CSCD 2020年第1期72-96,共25页
Highly efficient power amplifiers(PAs)and associated linearization techniques have been developed to accommodate the explosive growth in the data transmission rate and application of massive multiple input multiple ou... Highly efficient power amplifiers(PAs)and associated linearization techniques have been developed to accommodate the explosive growth in the data transmission rate and application of massive multiple input multiple output(mMIMO)systems.In this paper,energy-efficient integrated Doherty PA monolithic microwave integrated circuits(MMICs)and linearization techniques are reviewed for both the sub-6 GHz and millimeter-wave(mm-Wave)fifth-generation(5G)mMIMO systems;different semiconductor processes and architectures are compared and analyzed.Since the 5G protocols have not yet been finalized and PA specifications for mMIMO are still under consideration,it is worth investigating novel design methods to further improve their efficiency and linearity performance.Digital predistortion techniques need to evolve to be adapted in mMIMO systems,and some creative linearity enhancement techniques are needed to simultaneously improve the compensation accuracy and reduce the power consumption. 展开更多
关键词 ENERGY-EFFICIENT LINEARIZATION MASSIVE MULTIPLE input MULTIPLE output(mMIMO) Monolithic microwave integrated circuit(MMIC) Power AMPLIFIER
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Development of nonlinear disturbance observer based control and nonlinear PID: A personal note 被引量:2
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作者 wen-hua chen 《Control Theory and Technology》 EI CSCD 2018年第4期284-300,共17页
关键词 控制器 非线性 PID 开发 笔记 研究人员 试验性 操纵者
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Chattering-free sliding mode control with unidirectional auxiliary surfaces for miniature helicopters 被引量:2
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作者 Jian Fu wen-hua chen Qing-xian Wu 《International Journal of Intelligent Computing and Cybernetics》 EI 2012年第3期421-438,共18页
Purpose-This article proposes a chattering-free sliding mode control scheme with unidirectional auxiliary surfaces(UAS-SMC)for small miniature autonomous helicopters(Trex 250).Design/methodology/approach-The proposed ... Purpose-This article proposes a chattering-free sliding mode control scheme with unidirectional auxiliary surfaces(UAS-SMC)for small miniature autonomous helicopters(Trex 250).Design/methodology/approach-The proposed UAS-SMC scheme consists of a nested sequence of rotor dynamics,angular rate,Euler angle,velocity and position loops.Findings-It is demonstrated that the UAS-SMC strategy can eliminate the chattering phenomenon exhibiting in the convenient SMC method and achieve a better approaching speed.Originality/value-The proposed control strategy is implemented on the helicopter and flight tests clearly demonstrate that a much better performance could be achieved,compared with convenient SMC schemes. 展开更多
关键词 Unmanned aircraft Approaching speed Flight control Sliding mode control Helicopters CHATTERING
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Recursive Filter with Partial Knowledge on Inputs and Outputs
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作者 Jinya Su Baibing Li wen-hua chen 《International Journal of Automation and computing》 EI CSCD 2015年第1期35-42,共8页
This paper investigates the problem of state estimation for discrete-time stochastic linear systems, where additional knowledge on the unknown inputs is available at an aggregate level and the knowledge on the missing... This paper investigates the problem of state estimation for discrete-time stochastic linear systems, where additional knowledge on the unknown inputs is available at an aggregate level and the knowledge on the missing measurements can be described by a known stochastic distribution. Firstly, the available knowledge on the unknown inputs and the state equation is used to form the prior distribution of the state vector at each time step. Secondly, to obtain an analytically tractable likelihood function, the effect of missing measurements is broken down into a systematic part and a random part, and the latter is modeled as part of the observation noise. Then, a recursive filter is obtained based on Bayesian inference. Finally, a numerical example is provided to evaluate the performance of the proposed methods. 展开更多
关键词 BAYESIAN INFERENCE KALMAN filter MISSING measurements state estimation UNKNOWN INPUTS
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无人机污染源自主搜寻算法综述
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作者 李中国 陈文华 刘存佳 《中国科学:信息科学》 CSCD 北大核心 2022年第9期1579-1597,共19页
自主搜寻在环境保护、灾后搜救和工业监控等方面有重要作用.无人机传感平台凭借其灵活的机动性成为实现自主搜寻的有效途径之一.针对自主搜寻中两个关键任务,即污染源定位和污染边界跟踪,本文分别梳理了相关算法体系,并揭示了其设计思... 自主搜寻在环境保护、灾后搜救和工业监控等方面有重要作用.无人机传感平台凭借其灵活的机动性成为实现自主搜寻的有效途径之一.针对自主搜寻中两个关键任务,即污染源定位和污染边界跟踪,本文分别梳理了相关算法体系,并揭示了其设计思想的本质.对于污染物溯源,控制驱动和信息驱动两类算法是目前的研究主流,但两者的结合却鲜有报道.在边界跟踪方面,本文从单平台和多平台协作两方面总结了现有文献的控制和估计方法.根据双重控制思想,本文分析了相关算法的设计思路,并展望了下一步的研究重点. 展开更多
关键词 自主搜寻 无人机 污染源搜寻 边界跟踪 双重控制 探索与利用
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Curvature-regulated transmembrane anion transport by a trifluoromethylated bisbenzimidazole
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作者 Xiao-Qiao Hong Yuan-Yuan Xing +2 位作者 Zhong-Kun Wang Qin-Chao Mao wen-hua chen 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第5期1653-1656,共4页
In this paper,we demonstrate that modification of anion-transport:active l,3-bis(benzimidazol-2-yl)benzene with strongly electron-withdrawing trifluoromethyl and nitro groups leads to a dramatic increase in the aniono... In this paper,we demonstrate that modification of anion-transport:active l,3-bis(benzimidazol-2-yl)benzene with strongly electron-withdrawing trifluoromethyl and nitro groups leads to a dramatic increase in the anionophoric activity,and the activity may be greatly regulated by the curvatures of the liposomes used. 展开更多
关键词 Anion transporter Lysosomal curvature Anionophoric activity
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Anion-Responsive Manganese Porphyrin Facilitates Chloride Transport and Induces Immunogenic Cell Death
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作者 Fang-Xin Wang Jie-Wei Liu +5 位作者 Xiao-Qiao Hong Cai-Ping Tan Li Zhang wen-hua chen Peter J.Sadler Zong-Wan Mao 《CCS Chemistry》 CAS 2022年第7期2409-2419,共11页
Chloride is the most abundant anion in living systems.Most natural or synthetic chloride anionophores function via hydrogen-bonding interactions.However,dynamic metal-anion coordination can also be an efficient way of... Chloride is the most abundant anion in living systems.Most natural or synthetic chloride anionophores function via hydrogen-bonding interactions.However,dynamic metal-anion coordination can also be an efficient way of transporting chloride across membranes.Here,we investigate anion transport by manganese(Ⅲ)meso-tetraphenylporphyrin chloride{[Mn(TPP)Cl],TPP=meso-tetraphenylporphyrin}complex that exhibits labile axial coordination.[Mn(TPP)Cl]showed high chloride transport activity in a bilayer vesicle model with an EC_(50) value of 4.42×10^(−3) mol%.In living cells,[Mn(TPP)Cl]induced rapid chloride influx and autophagy.The release of Ca^(2+)and adenosine 5′-triphosphate(ATP),as well as the relocation of calreticulin,revealed that[Mn(TPP)Cl]caused immunogenic cell death.Proteomic analysis indicated that[Mn(TPP)Cl]impaired several physiological processes,including DNA synthesis,transcription,mitochondrial respiration,RNA translation,and immune response.Our study suggests that dynamic metal-anion interactions across membranes might provide a practical strategy for the interference of chloride homeostasis. 展开更多
关键词 manganese porphyrin anionophore chloride transport AUTOPHAGY immunogenic cell death
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