Finite element analysis of the treatment of middle clavicle fracture with wing plate internal fixation

Objective:To investigate the mechanical properties of a new type of biplane locking plate with wings in the treatment of middle clavicle fractures.Methods:Based on the CT data of a healthy adult male volunteer’s clavicle,a three-dimensional finite element model of the middle clavicle fracture was constructed by digital three-dimensional reconstruction technology,and the two kinds of fixation methods of single-plane locking plate(SP)and wing plate(WP)were simulated.Four load cases of axial compression,axial torsion,cantilever bending and pull-out were used to analyze the models.Results:①Under axial compression,axial torsion,cantilever bending and pull-out conditions,compared with SP,the stiffness phase of WP increased by 1.47%,5.82%,1.51%and 3.96%respectively,and the strain energy decreased by 1.50%,5.39%,1.48%and 3.49%respectively.②The stress distribution characteristics of WP under various load conditions were similar to SP,and the high stress area was located around the screw hole of the steel plate above the fracture gap;③Under the pull-out condition of WP,the peak value of screw hole surface stress was greatly reduced compared with SP,especially in the screw hole on both sides of the wing screws,which had higher resistance to pull out.Conclusion:The load-bearing mode of WP under various load conditions is similar to that of SP,and the stability is slightly higher than that of SP and in terms of pull-out resistance,WP has more obvious advantages.The biplane locking plate with wings is expected to be a more ideal choice for patients with comminuted fracture of the middle clavicle or with osteoporosis.

Integrinα6 Targeted Near Infrared Fluorescent Imaging and Photoacoustic Imaging of Hepatocellular Carcinoma in Mice

Background and Aims:Hepatocellular carcinoma(HCC)is the fourth most common cause of cancer-related death and ranks sixth in terms of incident cases worldwide.The purpose of this study was to develop an effective and sensitive method to distinguish liver cancer tissues from normal tissues in HCC patients.Integrinα6 is a promising cell surface target for molecular imaging of HCC,where it is overexpressed and is a prognostic biomarker.We previously identified an integrinα6-targeted peptide CRWYDENAC(RWY)that has been used for positron emission tomography(PET)imaging of HCC in mouse models.Methods:We labeled the integrinα6-targeted RWY peptide with cyanine 7(Cy7)to form an optical probe(Cy7-RWY)for near infrared fluorescent(NIRF)and photoacoustic(PA)imaging in HCC.Mice transplanted with subcutaneous HCC-LM3 or orthotopic HCC-H22 cells that overexpressed integrinα6 were intravenously injected with Cy7-RWY and its corresponding Cy7-control.NIRF and PA images of mice were collected from 0 to 48 h after injection.Results:Both NIRF and PA signals started to accumulate in the tumor 2 h after injection of Cy7-RWY and peaked at 24 h.Conclusions:Cy7-RWY is a promising optical probe for NIRF and PA imaging of HCC in mice,and has potential clinical application for HCC detection.