Advancements of molecular imaging and radiomics in pancreatic carcinoma

Despite the recent progress of medical technology in the diagnosis and treatment of tumors,pancreatic carcinoma remains one of the most malignant tumors,with extremely poor prognosis partly due to the difficulty in early and accurate imaging evaluation.This paper focuses on the research progress of magnetic resonance imaging,nuclear medicine molecular imaging and radiomics in the diagnosis of pancreatic carcinoma.We also briefly described the achievements of our team in this field,to facilitate future research and explore new technologies to optimize diagnosis of pancreatic carcinoma.

Lymphoplasmacyte-rich meningioma with atypical cystic-solid feature:A case report

BACKGROUND Lymphoplasmacyte-rich meningioma(LPRM)is one of the rarest variants of meningioma and is classified as grade I(benign)tumor.It is characterized by abundant infiltrates of lymphocytes and plasma cells.Here,we report an extremely rare case of LPRM with an atypical imaging finding of multiple cysts around a solid mass.CASE SUMMARY The patient was a 36-year-old man with intermittent headache,dizziness,and vomiting for 2 years.Computed tomography and magnetic resonance imaging presented a cystic solid mass in the right frontal lobe with heavy peritumoral edema and obvious contrast enhancement.The patient was treated with right frontotemporal craniotomy,and gross total resection of the tumor was achieved without adjuvant therapy.There was no clinical or neuroradiological evidence of recurrent or residual tumor for 3 years after initial surgery.CONCLUSION LPRM is one of the rarest variants of meningioma.Although,the mass of this case had common features,multiple cysts with nonuniform size and thin wall around the solid part are uncommon imaging finding,increasing the rate of misdiagnosis.The definitive diagnosis of LPRM relies on histopathological findings.

Protective antitumor immunity induced by tumor cell lysates conjugated with diphtheria toxin and adjuvant epitope in mouse breast tumor models

Cancer cell vaccine-based immunotherapy has received increasing interest in many clinical trials involving patients with breast cancer. Combining with appropriate adjuvants can enhance the weak immunogenic properties of tumor cell lysates (TCL). In this study, diphtheria toxin (DT) and two tandem repeats of mycobacterial heat shock protein 70 (mHSP70) fragment 407-426 (M2) were conjugated to TCL with glutaraldehyde, and the constructed cancer cell vaccine was named DT-TCL-M2. Subcutaneous injection of DT-TCL-M2in mice effectively elicited tumor-specific polyclonal immune responses, including humoral and cellular immune responses. High levels of antibodies against TCL were detected in the serum of immunized mice with ELISA and verified with Western blot analyses. The splenocytes from immunized mice showed potent cytotoxicity on Ehrlich ascites carcinoma cells. Moreover, the protective antitumor immunity induced by DT-TCL-M2 inhibited tumor growth in a mouse breast tumor model. DT-TCL-M2 also attenuated tumor-induced angiogenesis and slowed tumor growth in a mouse intradermal tumor model. These findings demonstrate that TCL conjugated with appropriate adjuvants induced effective antitumor immunity in vivo. Improvements in potency could further make cancer cell vaccines a useful and safe method for preventing cancer recurrence after resection.

Thermal wave propagation in graphene studied by molecular dynamics simulations

The transient heat conduction in both armchair and zigzag-edged graphene ribbons pulsed by local heating with a duration of 1 ps was studied using nonequilibrium molecular dynamics simulations. The results show that the heat pulse excites two waves which indicates non-Fourier heat conduction. One of the two waves is a sound wave(first sound), which has macroscopic momentum and propagates at the speed of sound. The other is a thermal wave(second sound), whose propagation speed is 1=ffiffi3pof the sound velocity. The sound wave excited by the heat pulse is a longitudinal wave, whose energy is only transported in the longitudinal direction. The thermal wave excited by the heat pulse is generated by transverse lattice vibrations, with the energy only having the transverse component. The observed anisotropy of the transient heat conduction suggests that the system is in a non-equilibrium state during propagation of the heat pulse. Further statistical analyses show that the displacement of the heat pulse energy is related to the time as hr2 i / t1:80, which implies that heat transport is ballistic-diffusive transport in graphene. The higher proportion of the ballistic transport will lead to stronger heat waves. At the crest of the thermal wave, energy is transported ballistically, while in the diffusive region and during attenuation of the thermal wave,the energy is transported diffusively.